Examination of potential mechanisms in the enhancement of cerebral blood flow by hypoglycemia and pharmacological doses of deoxyglucose

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 1, 1997, Pages 54-63

  Horinaka, Naoaki ^a   Artz, Nicole ^a   Jehle, Jane ^a   Takahashi, Shinichi ^a   Kennedy, Charles ^a   Sokoloff, Louis ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Glucoprivation; Insulin; Nitric oxide; 14C Iodoantipyrine

Indexed keywords

BICARBONATE; DEOXYGLUCOSE; INSULIN; IODOPHENAZONE C 14; LACTIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTICLE; BICARBONATE BLOOD LEVEL; BLOOD GAS TENSION; BLOOD PH; BRAIN BLOOD FLOW; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HYPOGLYCEMIA; LACTATE BLOOD LEVEL; MALE; NONHUMAN; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; RAT;

EID: 0031021284     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199701000-00008     Document Type: Article

References (39)

1. Abdul-Rahman A, Agardh CD, Siesjö BK (1980) Local cerebral blood flow in the rat during severe hypoglycemia, and in the recovery period following glucose injection. Acta Physiol Scand 109:307-314
2. Adachi K, Takahashi S, Melzer P, et al. (1994) Increases in local cerebral blood flow associated with somatosensory activation are not mediated by nitric oxide. Am J Physiol 267:H2155-2162
3. Berne RM, Rubio R, Curnish RR (1974) Release of adenosine from ischemic brain: effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides. Circ Res 35:262-271
4. Breier A, Crane AM, Kennedy C, Sokoloff L (1993) The effects of pharmacologic doses of 2-deoxy-D-glucose on local cerebral blood flow in the awake, unrestrained rat. Brain Res 618:277-282
5. Bryan RM, Keefer KA, MacNeill C (1986) Regional cerebral glucose utilization during insulin-induced hypoglycemia in unanesthetized rats. J Neurochem 46:1904-1911
6. Bryan RM, Hollinger BR, Keefer KA, Rage RB (1987) Regional cerebral and neural lobe blood flow during insulin-induced hypoglycemia in unanesthetized rats. J Cereb Blood Flow Metab 7:96-102
7. Bryan RM, Eichler MY, Johnson TD, Woodward WT, Williams JL (1994) Cerebral blood flow, plasma catecholamines, and electroencephalogram during hypoglycemia and recovery after glucose infusion. J Neurosurg Anesthesiol 6:24-34
8. Chapman AG, Westerberg E, Siesjö BK (1981) The metabolism of purine and pyrimidine nucleotides in rat cortex during insulin-induced hypoglycemia and recovery. J Neurochem 36:179-189
9. Della Porta P, Maiolo AT, Negri UV, Rossella E (1964) Cerebral blood flow and metabolism in the therapeutic insulin coma. Metabolism 13:131-140
10. Duckrow RB (1988) Regional cerebral blood flow and glucose utilization during hyperinsulinemia. Brain Res 462:363-366
11. G-nitroarginine in brain in vitro and in vivo. Biochem Biophys Res Commun 176:1136-1141
12. Edvinsson L, McCulloch J, MacKenzie ET (1993) Cerebral Blood Flow and Metabolism. New York, Raven Press, pp 183-230
13. Eisenberg S, Seltzer HY (1962) The cerebral metabolic effects of acutely induced in hypoglycemia in human subjects. Metabolism 11:1162-1168
14. Frerichs KU, Kennedy C, Sokoloff L, Hallenbeck JM (1994) Local cerebral blood flow during hibernation: A model of natural tolerance to cerebral ischemia. J Cereb Blood Flow Metab 14:193-205
15. Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 228:373-376
16. Ghajar JBG, Plum F, Duffy TE (1982) Cerebral oxidative metabolism and blood flow during acute hypoglycemia and recovery in unanesthetized rats. J Neurochem 38:397-409
17. Hernandez MJ, Vannucci RW, Salcedo A, Brennan RW (1980) Cerebral blood flow and metabolism during hypoglycemia in new born dogs. J Neurochem 35:622-628
18. Hollinger BR, Bryan RM (1987) β-Receptor-mediated increase in cerebral blood during hypoglycemia. Am J Physiol 253:H949-H955
19. Horinaka N, Kennedy C, Artz N, Jehle J, Sokoloff L (1995) Effects of nitric oxide synthase inhibition on the cerebral blood flow response to hypoglycemia. J Cereb Blood Flow Metab 15(Suppl 1):S475
20. Horton RW, Meldrum BS, Bachelard HS (1973) Enzymic and cerebral metabolic effects of 2-deoxy-D-glucose. J Neurochem 21:507-520
21. Iadecola C, Xu X, Zhang F, Hu J, El-Fakahany EE (1994) Prolonged inhibition of brain nitric oxide synthase by short-term systemic administration of nitro-L-arginine methyl ester. Neurochem Res 19:501-505
22. Ichord RN, Helfaer MA, Kirsch JR, Wilson D, Traystman RJ (1994) Nitric oxide synthase inhibition attenuates hypoglycemic cerebral hyperemia in piglets. Am J Physiol 266:H1062-H1068
23. Ignarro LJ, Buga GM, Wood KS, Bryns RE, Chaudhuri G (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84:9265-9269
24. Ignarro LJ (1989) Biological action and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res 65:1-21
25. Kety SS, Woodford RB, Harmel MH, Freyman FA, Appel KE, Schmidt CF (1948) Cerebral blood flow and metabolism in schizophrenia. Am J Psychiatry 104:765-770
26. Kuschinsky W, Wahl M (1978) Local chemical and neurogenic regulation of cerebral vascular resistance. Physiol Rev 58:656-689
27. King BD, Sokoloff L, Wechsler RL (1952) The effects of 1-epinephrine and 1-nor-epinephrine upon cerebral circulation and metabolism in man. J Clin Invest 31:273-279
28. Landau BR, Laszlo J, Stengle J, Burk D (1958) Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose. J Natl Cancer Inst 21:485-494
29. Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142
30. Norberg K, Siesjö BK (1976) Oxidative metabolism of the cerebral cortex of the rat in severe insulin-induced hypoglycemia. J Neurochem 26:345-352
31. Palmer RMJ, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524-526
32. Ratcheson RA, Blank AC, Ferrendelli JA (1981) Regionally selective metabolic effects of hypoglycemia in brain. J Neurochem 36: 1952-1958
33. 14C]antipyrine. Am J Physiol 234:H59-H66
34. Siesjö BK, Ingvar M, Pelligrino D (1983) Regional differences in vascular autoregulation in the rat brain in severe insulin-induced hypoglycemia. J Cereb Blood Flow Metab 3:478-485
35. Sokoloff L, Kennedy C, Adachi K, Wang F, Takahashi S, Melzer P (1992) Effects of inhibitors of nitric oxide synthase on resting local cerebral blood flow and on the changes induced by hypercapnia or local functional activity. In: Pharmacology of Cerebral Ischemia 1992 (Kriegelstein J, Oberpichler H, eds.) Stuttgart, Wissenschaftliche Verlagsgesellschaft mbh, 1992, pp 371-382
36. Suda S, Shinohara M, Miyaoka M, Lucignani G, Kennedy C, Sokoloff L (1990) The lumped constant of the deoxyglucose method in hypoglycemia: effects of moderate hypoglycemia on local cerebral glucose utilization in the rat. J Cereb Blood Flow Metab 10:499-509
37. Van Wylen DG, Park TS, Rubio R, Berne RM (1989) The effect of local infusion of adenosine analogues on local cerebral blood flow. J Cereb Blood Flow Metab 9:556-562
38. G-nitro-L-arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats. Brain Res 641:257-264
39. Wick AN, Drury DR, Nakada HI, Wolfe JB (1957) Localization of the primary metabolic block produced by 2-deoxyglucose. J Biol Chem 224:963-969