메뉴 건너뛰기




Volumn 124, Issue 3, 1998, Pages 507-512

Depression of NMDA receptor-mediated synaptic transmission by four α2 adrenoceptor agonists on the in vitro rat spinal cord preparation

Author keywords

2 adrenoceptor agonists; Detomidine; Dexmedetomidine; Romifidine; Spinal cord; Xylazine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ATIPAMEZOLE; DETOMIDINE; DEXMEDETOMIDINE; IMIDAZOLINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; ROMIFIDINE; XYLAZINE;

EID: 0031747034     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701873     Document Type: Article
Times cited : (28)

References (46)
  • 1
    • 0021800096 scopus 로고
    • The role of substance P as a neurotransmitter in the reflexes of slow time courses in the neonatal rat spinal cord
    • AKAGI, H., KONISHI, S., OTSUKA, M. & YANAGISAWA, M. (1985). The role of substance P as a neurotransmitter in the reflexes of slow time courses in the neonatal rat spinal cord. Br. J. Pharmacol., 84, 663-673.
    • (1985) Br. J. Pharmacol. , vol.84 , pp. 663-673
    • Akagi, H.1    Konishi, S.2    Otsuka, M.3    Yanagisawa, M.4
  • 2
    • 0018143444 scopus 로고
    • The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurons in the cat
    • BELCHER, G., RYALL, R.W. & SCHAFFNER, R. (1978). The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurons in the cat. Brain Res., 151, 307-321.
    • (1978) Brain Res. , vol.151 , pp. 307-321
    • Belcher, G.1    Ryall, R.W.2    Schaffner, R.3
  • 4
    • 0022620198 scopus 로고
    • Presynaptic effect of clonidine on unmyelinated afferent fibres in the spinal cord of the cat
    • CALVILLO, O. & GHIGNONE, M. (1986). Presynaptic effect of clonidine on unmyelinated afferent fibres in the spinal cord of the cat. Neurosci. Lett., 64, 335.
    • (1986) Neurosci. Lett. , vol.64 , pp. 335
    • Calvillo, O.1    Ghignone, M.2
  • 5
    • 0022348165 scopus 로고
    • Selective inhibition of responses in feline dorsal horn neurons to noxious cutaneous stimuli by tizanidine (DS-103-282) and noradrenaline: Involvement of α adrenoceptors
    • DAVIES, J. & QUINLAN, J.E. (1985). Selective inhibition of responses in feline dorsal horn neurons to noxious cutaneous stimuli by tizanidine (DS-103-282) and noradrenaline: Involvement of α adrenoceptors. Neuroscience, 16, 673-682.
    • (1985) Neuroscience , vol.16 , pp. 673-682
    • Davies, J.1    Quinlan, J.E.2
  • 6
    • 0028239559 scopus 로고
    • Expression of μ opioid receptor messenger-RNA in rat brain- and in situ hybridisation study at the single cell level
    • DELFS, J.M., KONG, H.Y., MESTEK, A., CHEN, Y., YU, L., REISINE, T. & CHESSELET, M.F. (1994). Expression of μ opioid receptor messenger-RNA in rat brain- and in situ hybridisation study at the single cell level. J. Comp. Neurol., 345, 46-68.
    • (1994) J. Comp. Neurol. , vol.345 , pp. 46-68
    • Delfs, J.M.1    Kong, H.Y.2    Mestek, A.3    Chen, Y.4    Yu, L.5    Reisine, T.6    Chesselet, M.F.7
  • 8
    • 0023090454 scopus 로고
    • Epidural clonidine produces antinociception, but not hypotension in sheep
    • EISENACH, J.C., DEWAN, D., ROSE, J. & ANGELO, J. (1987). Epidural clonidine produces antinociception, but not hypotension in sheep. Anaesthesiology, 66, 496-501.
    • (1987) Anaesthesiology , vol.66 , pp. 496-501
    • Eisenach, J.C.1    Dewan, D.2    Rose, J.3    Angelo, J.4
  • 9
    • 84916004858 scopus 로고
    • The inhibitory action of noradrenaline and other monoamines on spinal neurons
    • ENGBERG, I. & RYALL, R. (1966). The inhibitory action of noradrenaline and other monoamines on spinal neurons. J. Physiol., 185, 298-322.
    • (1966) J. Physiol. , vol.185 , pp. 298-322
    • Engberg, I.1    Ryall, R.2
  • 10
    • 15644378001 scopus 로고
    • Modulation of the polysynaptic reflex of the rat hemisected spinal cord by xylazine and detomidine in vitro
    • FABER, E.S.L., EVANS, R.H. & CHAMBERS, J.P. (1995). Modulation of the polysynaptic reflex of the rat hemisected spinal cord by xylazine and detomidine in vitro. Br. J. Pharmacol., 116, 311P.
    • (1995) Br. J. Pharmacol. , vol.116
    • Faber, E.S.L.1    Evans, R.H.2    Chambers, J.P.3
  • 11
    • 0030977786 scopus 로고    scopus 로고
    • Depression of a and C fibre-evoked segmental reflexes by morphine and clonidine in the in vitro spinal cord of the neonatal rat
    • FABER, E.S.L., CHAMBERS, J.P., BRUGGER, F. & EVANS, R.H. (1997a). Depression of A and C fibre-evoked segmental reflexes by morphine and clonidine in the in vitro spinal cord of the neonatal rat. Br. J. Pharmacol., 120, 1390-1396.
    • (1997) Br. J. Pharmacol. , vol.120 , pp. 1390-1396
    • Faber, E.S.L.1    Chambers, J.P.2    Brugger, F.3    Evans, R.H.4
  • 12
    • 15644369263 scopus 로고    scopus 로고
    • Effect of dexmedetomidine on NMDA receptor-mediated synaptic transmission in the neonatal rat hemistected spinal cord preparation in vitro
    • FABER, E.S.L., CHAMBERS, J.P. & EVANS, R.H. (1997b). Effect of dexmedetomidine on NMDA receptor-mediated synaptic transmission in the neonatal rat hemistected spinal cord preparation in vitro. Br. J. Pharmacol., 122, 36P.
    • (1997) Br. J. Pharmacol. , vol.122
    • Faber, E.S.L.1    Chambers, J.P.2    Evans, R.H.3
  • 13
    • 0021910919 scopus 로고
    • 2 receptor mediates the selective inhibition by noradrenaline of nociceptive responses of identified dorsal horn neurons
    • 2 receptor mediates the selective inhibition by noradrenaline of nociceptive responses of identified dorsal horn neurons. Brain Res., 334, 243-254.
    • (1985) Brain Res. , vol.334 , pp. 243-254
    • Fleetwood-Walker, S.M.1    Mitchell, R.2    Hope, P.J.3    Moloney, V.4    Iggo, A.5
  • 14
    • 0022461848 scopus 로고
    • Descending inhibition of slow spinal reflex in an in vitro preparation of the newborn rat and its possible involvement in pain control
    • GARCIA-ARRARAS, J.E., MURAKOSHI, T., YANAGISAWA, M. & OTSUKA, M. (1986). Descending inhibition of slow spinal reflex in an in vitro preparation of the newborn rat and its possible involvement in pain control. Brain Res., 379, 188-191.
    • (1986) Brain Res. , vol.379 , pp. 188-191
    • Garcia-Arraras, J.E.1    Murakoshi, T.2    Yanagisawa, M.3    Otsuka, M.4
  • 15
    • 0028979177 scopus 로고
    • 2 adrenoceptor agonist in the spinal dorsal horn is due to a direct spinal action and not to activation of descending inhibition
    • 2 adrenoceptor agonist in the spinal dorsal horn is due to a direct spinal action and not to activation of descending inhibition. Brain Res. Bull., 37, 581-587.
    • (1995) Brain Res. Bull. , vol.37 , pp. 581-587
    • Hamalainen, M.M.1    Pertovaara, A.2
  • 16
    • 0028910345 scopus 로고
    • Sedative and analgesic effects of detomidine and romifidine in horses
    • HAMM, D., TURCHI, P. & JOCHLE, W. (1995). Sedative and analgesic effects of detomidine and romifidine in horses. Veterinary Record, 136, 324-327.
    • (1995) Veterinary Record , vol.136 , pp. 324-327
    • Hamm, D.1    Turchi, P.2    Jochle, W.3
  • 17
    • 0027245836 scopus 로고
    • 2-Adrenoceptor agonists and anaesthesia
    • 2-Adrenoceptor agonists and anaesthesia. Br. J. Anaesth., 71, 108-118.
    • (1993) Br. J. Anaesth. , vol.71 , pp. 108-118
    • Hayashi, Y.1    Maze, M.2
  • 19
    • 0023198199 scopus 로고
    • 2 adrenoceptor binding to, and the substance P, enkephalin, and neurotensin content of, the cat lumbar spinal cord
    • 2 adrenoceptor binding to, and the substance P, enkephalin, and neurotensin content of, the cat lumbar spinal cord. Neuroscience, 21, 385-394.
    • (1987) Neuroscience , vol.21 , pp. 385-394
    • Howe, J.R.1    Yaksh, T.L.2    Go, V.L.W.3
  • 21
    • 0027941976 scopus 로고
    • Antinociceptive actions of dexmedetomidine and the kappa-opioid agonist U50.488H against noxious thermal, mechanical and inflammatory stimuli
    • IDANPAAN-HEIKKILA, J.J., KALSO, E.A. & SAPPALA, T. (1994). Antinociceptive actions of dexmedetomidine and the kappa-opioid agonist U50.488H against noxious thermal, mechanical and inflammatory stimuli. J. Pharmacol. Exp. Ther., 271, 1306-1313.
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 1306-1313
    • Idanpaan-Heikkila, J.J.1    Kalso, E.A.2    Sappala, T.3
  • 22
    • 0023943476 scopus 로고
    • Objective assessment of detomidine-induced analgesia and sedation in the horse
    • KAMERLING, S.G., CRAVENS, W.M.T. & BAGWELL, C.A. (1988). Objective assessment of detomidine-induced analgesia and sedation in the horse. Eur. J. Pharmacol., 151, 1-8.
    • (1988) Eur. J. Pharmacol. , vol.151 , pp. 1-8
    • Kamerling, S.G.1    Cravens, W.M.T.2    Bagwell, C.A.3
  • 24
    • 0022365944 scopus 로고
    • Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn
    • KURAISHI, Y., HIROTA, N., SATO, Y., KANEKO, S., SATOH, M. & TAKAGI, H. (1985). Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn. Brain Res., 359, 177-182.
    • (1985) Brain Res. , vol.359 , pp. 177-182
    • Kuraishi, Y.1    Hirota, N.2    Sato, Y.3    Kaneko, S.4    Satoh, M.5    Takagi, H.6
  • 25
    • 2442521467 scopus 로고
    • Analgesia and anaesthesia induced by epinephrine
    • LEIMDORFER, A. & METZNER, W.R. (1949). Analgesia and anaesthesia induced by epinephrine. Am. J. Physiol., 157, 116-121.
    • (1949) Am. J. Physiol. , vol.157 , pp. 116-121
    • Leimdorfer, A.1    Metzner, W.R.2
  • 27
    • 0024215586 scopus 로고
    • Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative
    • MACDONALD, E., SCHEININ, H. & SCHEININ, M. (1988). Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative. Eur. J. Pharmacol., 158, 119-127.
    • (1988) Eur. J. Pharmacol. , vol.158 , pp. 119-127
    • Macdonald, E.1    Scheinin, H.2    Scheinin, M.3
  • 30
    • 0021287154 scopus 로고
    • The actions of noradrenaline on neurons of the rat substantia gelatinosa in vitro
    • NORTH, R.A. & YOSHIMURA, M. (1984). The actions of noradrenaline on neurons of the rat substantia gelatinosa in vitro. J. Physiol., 349, 43-55.
    • (1984) J. Physiol. , vol.349 , pp. 43-55
    • North, R.A.1    Yoshimura, M.2
  • 33
    • 0018885888 scopus 로고
    • Spinal cord pharmacology of adrenergic agonist-mediated antinoception
    • REDDY, S.V.R., MADERDRUT, J.L. & YAKSH, T.L. (1980). Spinal cord pharmacology of adrenergic agonist-mediated antinoception. J. Pharmacol. Exp. Ther., 213, 525-533.
    • (1980) J. Pharmacol. Exp. Ther. , vol.213 , pp. 525-533
    • Reddy, S.V.R.1    Maderdrut, J.L.2    Yaksh, T.L.3
  • 34
    • 0030583104 scopus 로고    scopus 로고
    • Alpha-2A/D adrenoceptor subtype predominates also in the neonatal rat spinal cord
    • SAVOLA, M.K.T. & SAVOLA, J.-M. (1996). Alpha-2A/D adrenoceptor subtype predominates also in the neonatal rat spinal cord. Develop. Brain Res., 94, 106-108.
    • (1996) Develop. Brain Res. , vol.94 , pp. 106-108
    • Savola, M.K.T.1    Savola, J.-M.2
  • 35
    • 0026699756 scopus 로고
    • The effect of centrally acting myorelaxants on NMDA receptor-mediated synaptic transmission in the immature rat spinal cord in vitro
    • SIAREY, R.J., LONG, S.K. & EVANS, R.H. (1992). The effect of centrally acting myorelaxants on NMDA receptor-mediated synaptic transmission in the immature rat spinal cord in vitro. Br. J. Pharmacol., 107, 628-633.
    • (1992) Br. J. Pharmacol. , vol.107 , pp. 628-633
    • Siarey, R.J.1    Long, S.K.2    Evans, R.H.3
  • 38
    • 0023277297 scopus 로고
    • 2 Adrenoceptor modulation of nociception in rat spinal cord: Location, effects and interactions with morphine
    • 2 Adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine. Eur. J. Pharmacol., 138, 169-177.
    • (1987) Eur. J. Pharmacol. , vol.138 , pp. 169-177
    • Sullivan, A.F.1    Dashwood, M.R.2    Dickenson, A.H.3
  • 39
    • 0026590732 scopus 로고
    • The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetised rat
    • SULLIVAN, A.F., KALSO, E.A., MCQUAY, H.J. & DICKENSON, A.H. (1992). The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetised rat. Eur. J. Pharmacol. 215, 127-133.
    • (1992) Eur. J. Pharmacol. , vol.215 , pp. 127-133
    • Sullivan, A.F.1    Kalso, E.A.2    Mcquay, H.J.3    Dickenson, A.H.4
  • 40
    • 0022779289 scopus 로고
    • Antinociceptive activity and mechanism of action of detomidine
    • VIRTANEN, R. (1986). Antinociceptive activity and mechanism of action of detomidine. J. Vet. Pharmacol. Ther., 9, 286-292.
    • (1986) J. Vet. Pharmacol. Ther. , vol.9 , pp. 286-292
    • Virtanen, R.1
  • 43
    • 0021966740 scopus 로고
    • Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing
    • YAKSH, T.L. (1985). Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol. Biochem. Behav., 22, 845-857.
    • (1985) Pharmacol. Biochem. Behav. , vol.22 , pp. 845-857
    • Yaksh, T.L.1
  • 45
    • 0019449982 scopus 로고
    • Studies in the primate on the analgesic effects associated with intrathecal actions of opiates, α-adrenergic agonists and baclofen
    • YAKSH, T.L. & REDDY, S.V.R. (1981). Studies in the primate on the analgesic effects associated with intrathecal actions of opiates, α-adrenergic agonists and baclofen. Anaesthesiology, 54, 451-467.
    • (1981) Anaesthesiology , vol.54 , pp. 451-467
    • Yaksh, T.L.1    Reddy, S.V.R.2
  • 46
    • 0021674605 scopus 로고
    • Tail-pinch method in vitro and the effects of some antinociceptive compounds
    • YANAGISAWA, M., MURAKOSHI, T., TAMAI, S. & OTSUKA, M. (1985). Tail-pinch method in vitro and the effects of some antinociceptive compounds. Eur. J. Pharmacol., 106, 231-239.
    • (1985) Eur. J. Pharmacol. , vol.106 , pp. 231-239
    • Yanagisawa, M.1    Murakoshi, T.2    Tamai, S.3    Otsuka, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.