Influence of food intake on the bioavailability of thioctic acid enantiomers [3]

European Journal of Clinical Pharmacology

Volumn 50, Issue 6, 1996, Pages 513-514

  Gleiter, C H ^a   Schug, B S ^b   Hermann, R ^c   Elze, M ^b   Blume, H H ^b   Gundert Remy, U ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b ABDA Bundesvereinigung Deutscher Apothekerverbande   (Germany)

^c ASTA MEDICA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

THIOCTIC ACID;

ADULT; BIOAVAILABILITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; ENANTIOMER; FEMALE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LETTER; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; MALE; POSTPRANDIAL PERIOD; STEREOISOMERISM; THIOCTIC ACID;

EID: 0029743763     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050151     Document Type: Letter

References (4)

1. Gleiter CH, Hermann R, Wildgrube HJ, Ruus P, Niebch G, Nowak H (1995) Does impaired gastric emptying in diabetic patients alter the bioavailability of alpha-lipoic acid enantiomers? Thérapie 50 [Suppl]:403
2. Hermann R, Niebch G, Borbe HO, Fieger H, Ruus P, Nowak H, Riethmüller-Winzen, Peukert M, Blume H (1996) Enantio-selective pharmacokinetics and bioavailability of different racemic α-lipoic acid formulations in healthy volunteers. Eur J Pham Sci (in press)
3. Stenijans VW, Hartmann M, Huber R, Radke HW (1991) Lack of pharmacokinetic interaction as an equivalence problem. Int J Clin Pharmacol Ther Toxicol 29:323-328
4. Ziegler D, Hanefeld M, Ruhnau KJ, Meißner HP, Lobisch M, Schütte K, Gries FA, and the ALADIN study group (1995) Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant α-lipoic acid. Diabetologia 38: 1425-1433