Quiescent memory B cells in human peripheral blood co-express bcl-2 and bcl-x(L) anti-apoptotic proteins at high levels

European Journal of Immunology

Volumn 28, Issue 12, 1998, Pages 4418-4423

  Bovia, Fabrice ^a   Nabili Tehrani, Ali C ^a   Werner Favre, Christiane ^a   Barnet, Marc ^a   Kindler, Vincent ^a   Zubler, Rudolf H ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Apoptosis; Bcl x(L); Human memory B cell

Indexed keywords

MESSENGER RNA; PROTEIN BCL 2;

ARTICLE; B LYMPHOCYTE; CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MEMORY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0031740021     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199812)28:12<4418::aid-immu4418>3.0.co;2-7     Document Type: Article

References (16)

1. Adams, J. M. and Cory, S., The bcl-2 protein family: arbiters of cell survival. Science 1998. 281: 1322-1326.
2. Grillot, D. A. M., Merino, R., Pena, J. C., Fanslow, W. C., Finkelman, F. D., Thompson, C. B. and Nunez, G., bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J. Exp. Med. 1996. 183: 381-391.
3. Ohta, K., Iwai, K., Kasahara, Y., Taniguchi, N., Krajewski, S., Reed, J. C. and Miyawaki, T., Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-x and Mcl-1, in human peripheral blood and lymphoid tissues. Int. Immunol. 1995. 7: 1817-1825.
4. Choi, M. S., Holmann, M., Atkins, C. J. and Klaus, G. G., Expression of bcl-x during mouse B cell differentiation and following activation by various stimuli. Eur. J. Immunol. 1996. 26: 676-682.
5. Tuscano, J. M., Druey, K. M., Riva, A., Pena, J., Thompson, C. B. and Kehrl, J. H., Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center. Blood 1996. 88: 1359-1364.
6. Grimaître, M., Werner-Favre, C., Kindler, V. and Zubler, R. H., Human naive B cells cultured with EL-4 T cells mimic a germinal center-related B cell stage before generating plasma cells. Concordant changes in Bcl-2 protein and messenger RNA levels. Eur. J. Immunol. 1997. 27: 199-205.
7. Gottschalk, A. R., Boise, L. H., Thompson, C. B. and Quintans, J., Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc. Natl. Acad. Sci. USA 1994. 91: 7350-7354.
8. Mazel, S., Burtrum, D. and Petrie, H. T., Regulation of cell division cycle progression by bcl-2 expression: A potential mechanism for inhibition of programmed cell death. J. Exp. Med. 1996. 183: 2219-2226.
9. Schittek, B. and Rajewski, K., Maintenance of B cell memory by long-lived cells generated from proliferating precursors. Nature 1990. 346: 749-751.
10. Liu, Y.-J., Barthelemy, C., de Bouteiller, O., Arpin, C., Durand, I. and Banchereau, J., Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 1995. 2: 239-248.
11. Kindler, V. and Zubler, R. H., Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3. J. Immunol. 1997. 159: 2085-2090.
12. Miyashita, T., Mcllraith, M. J., Grammer, A. C., Miura, Y., Attrep, J. F., Shimaoka, Y. and Lipsky, P. E., Bidirectional regulation of human B cell responses by CD40-CD40 ligand interactions. J. Immunol. 1997. 158: 4620-4633.
13. Ghia, P., Boussiotis, V. A., Schultze, J. L., Cardoso, A. A., Dorfman, D. M., Gribben, J. G., Freedman, A. S. and Nadler, L. M., Unbalanced expression of Bcl-2 family proteins in follicular lymphoma: Contribution of CD40 signaling in promoting survival. Blood 1998. 91: 244-251.
14. Tomayko, M. M. and Cancro, M. P., Long-lived B cells are distinguished by elevated expression of A1. J. Immunol. 1998. 160: 107-111.
15. Lam, K.-P., Kühn, R. and Rajewski, K., In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997. 90: 1073-1083.
16. L permits anti-immunoglobulin(Ig)-induced proliferation in xid B cells. J. Exp. Med. 1998. 187: 1081-1091.