Molecular modelling of oestrone sulphatase inhibitors

Pharmacy and Pharmacology Communications

Volumn 4, Issue 10, 1998, Pages 481-483

  Ahmed, Sabbir ^a   James, Karen ^a   Sampson, Luther ^a  

^a KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; OESTRONE SULPHATASE; OESTRONE SULPHATASE INHIBITOR; SULFATASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVE SITE; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

EID: 0031734275     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Howarth, N. M., Purohit, A., Reed, M. J., Potter, B. V. L. (1997) Estrone sulfonates as inhibitors of estrone sulfatase. Steroids 62: 346-350
2. Purohit, A., Potter, B. V. L., Parker, M. G., Reed, M. J. (1998) Steroid sulphatase: expression, isolation and inhibition for active-site identification studies. Chem. Biol. Interact. 109: 183-193
3. Selcer, K. W., Jagannathan, S., Rhodes, M. E., Li, P. -K. (1996) Inhibition of placental estrone sulfatase activity and MCF-7 breast cancer cell proliferation by estrone-3-amino derivatives. J. Steroid Biochem. Mol. Biol. 59: 83-91
4. Woo, L. W. L., Purohit, A., Reed, M. J., Potter, B. V. L. (1997) Oestrone-3-O-(N-acetyl) sulphamate, a potential molecular probe of the active site of oestrone sulphatase. Bioorg. Med. Chem. Lett. 7: 3075-3080