Elevated connexin-43 expression in term human myometrium correlates with elevated c-Jun expression and is independent of myometrial estrogen receptors

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 4, 1998, Pages 1177-1185

  Geimonen, Erika ^a   Boylston, Eileen ^a   Royek, Anthony ^a   Andersen, Janet ^a,b  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; ESTROGEN RECEPTOR; ONCOPROTEIN; PROGESTERONE RECEPTOR;

ADULT; ARTICLE; ESTROGEN BINDING; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MYOMETRIUM; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING;

ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADULT; CELLS, CULTURED; CONNEXIN 43; ESTROGENS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LABOR, OBSTETRIC; MEMBRANE PROTEINS; MIDDLE AGED; MYOMETRIUM; PREGNANCY; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, ESTROGEN; SP1 TRANSCRIPTION FACTOR;

EID: 0031733002     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.4.1177     Document Type: Article

References (50)

1. Geimonen E, Jiang W, Ali M, Fishman GI, Garfield RE, Andersen J. 1996 Activation of protein kinase C in human uterine smooth muscle induces connexin43 gene transcription through an AP-1 site in the promoter sequence. J Biol Chem. 271:23667-23674.
2. Garfield RE, Sims S, Daniel EE. 1977 Gap junctions: their presence and necessity in myometrium during parturition. Science 198:958-959.
3. Garfield RE. 1985 Cell-to-cell communication in smooth muscle. In: Grover AK, Daniel EE, eds. Calcium and contractility: smooth muscle, chapt 6. Clifton: Humana Press; 143-173.
4. Goodenough DA, Goliger JA, Paul DL. 1996 Connexins, connexons, and intercellular communication. Annu Rev Biochem. 65:475-502.
5. Garfield RE, Puri CP, Csapo AI. 1982 Endocrine, structural and functional changes in the uterus during premature labor. Am J Obstet Gynecol. 142:21-27.
6. MacKenzie LW, Garfield RE. 1986 Effects of 17β-estradiol on myometrial gap junctions and pregnancy in the rat. Can J Physiol Pharmacol. 64:462-466.
7. Balducci J, Risek B, Gilula NB, Hand A, Egan JFX, Vintzileos AM. 1993 Gap junction formation in human myometrium: a key to preterm labor? Am J Obstet Gynecol. 168:1609-1615.
8. Risek B, Guthrie S, Kumar N, Gilula NB. 1990 Modulation of gap junction transcripts and protein expression during pregnancy in the rat. J Cell Biol. 110:269-282.
9. Tabb T, Thilander G, Grover A, Hertzberg E, Garfield R. 1992 An immunochemical and immunocytologic study of the increase in myometrial gap junctions (and connexin 43) in rats and humans during pregnancy. Am J Obstet Gynecol. 167:559-567.
10. Garfield RE, Kannan MS, Daniel EE. 1980 Gap junction formation in myometrium: control by estrogens, progesterone and prostaglandins. Am J Physiol. 238:C81-C89.
11. Zhao K, Kuperman L, Geimonen E, Andersen J, 1996 Progestin represses human connexin43 gene expression similarly in primary cultures of myometrial and uterine leiomyomas. Biol Reprod. 54:607-615.
12. Hendrix EM, Mao SJT, Everson W, Larsen WJ. 1992 Myometrial connexin 43 trafficking and gap junction assembly at term and in preterm labor. Mol Reprod Dev. 33:27-38.
13. Lye SJ, Nicholson BJ, Mascarenhas M, Mackensie L, Petrocelli T. 1993 Increased expression of connexin43 in rat myometrium during labor is associated with an increase in the plasma estrogen:progesterone ratio. Endocrinology. 132:2380-2386.
14. Garfield RE, Rabideau S, Challis JRG, Daniel EE. 1979: Hormonal control of GAP junction formation in sheep myometrium during parturition. Biol Reprod. 21:999-1007.
15. Mazor M, Wiznitzer A, Levy J, et al. 1993 The relationship between estrogen/ progesterone ratio and term human parturition. Isr J Med Sci. 29:97-99.
16. Friberg J. 1985 Pregnancy endocrinology. In: Gleicher N, ed. Principles of medical therapy in pregnancy. New York, London: Plenum Medical; 145-151.
17. Madanes AE. 1985 Endocrinology of the placenta. In: Gleicher N, ed. Principles of medical therapy in pregnancy. New York, London: Plenum Medical; 152-162.
18. Curran T, Franza BR. 1988 Fos and Jun: the AP-1 connection. Cell. 56:395-397.
19. Karin M. 1995 The rgulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 270:16483-16486.
20. Kadonaga JT, Jones KA, Tjian R. 1986 Promoter-specific activation of RNA polymerase II transcription by SP1. Trends Biochem Sci. 11:20-23.
21. Giannopoulos G, Tulchinsky D. 1979 Cytoplasmic and nuclear progestin receptors in human myometrium during the menstrual cycle and in pregnancy at term. J Clin Endocrinol Metab. 49:100-106.
22. Brandon DD, Erickson TE, Keenan EJ, et al. 1995 Estrogen receptor gene expression in human uterine leiomyomata. J Clin Endocrinol Metab. 80:1876-1881.
23. Andersen J, Grine EA, Eng CL-Y, et al. 1993 Expression of connexin43 in human myometrium and leiomyomas. Am J Obstet Gynecol. 169:1266-1276.
24. Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS. 1986 Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci USA. 83:2496-2500.
25. Andersen J, DyReyes V, Barbieri RL, Coachman D, Miksicek R. 1995 Leiomyoma primary cultures have elevated transcriptional response to estrogen compared to autologous myometrial cultures. J Soc Gynecol Invest. 2:542-551.
26. Stancel GM, Boettger-Tong H, Hyder SM, Kirkland JL, Loose-Mitchell DS. 1994 Uterine c-fos: a paradigm for control of gene expression during estrogen stimulated target tissue growth. In: Khan SA, Stancel GM, eds. Protooncogenes and growth factors in steroid hormone induced growth and differentiation, chapt 6. Boca Raton: CRC Press; 87-104.
27. Spelsberg TC, Subramaniam M, Harris SA, et al. 1994 Nuclear protooncogenes as regulatory genes and as marker genes for steroid action in all target tissues. In: Khan SA, Stancel GM, eds. Protooncogenes and growth factors in steroid hormone induced growth and differentiation, chapt 5. Boca Raton: CRC Press; 69-86.
28. Khan SA, Nephew KP, Wang H. 1994 The jun protooncogene family in uterine growth and differentiation. In: Khan SA, Stancel GM, eds. Protooncogenes and growth factors in steroid hormone induced growth and differentiation, chapt 7. Boca Raton: CRC Press; 105-122.
29. Kushner PJ, Baxter JD, Duncan KG, et al. 1994 Eukaryotic regulatory elements lurking in plasmid DNA: the activator protein site-1 in pUC. Mol Endocrinol. 8:405-407.
30. Klock G, Strähle U, Schütz G. 1987 Oestrogen and glucocorticoid-responsive gene are closely related but distinct. Nature. 329:734-736.
31. Wang Y, Miksicek RJ. 1991 Identification of a dominant negative form of the human estrogen receptor. Mol Endocrinol. 5:1707-1715.
32. Tora L, Mullick A, Metzger D, Ponglikitmongkol, Park I, Chambon P. 1989 The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. EMBO J. 8:1981-1986.
33. Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J. 1996 Cloning of a novel estrogen receptor expressed in rat prostrate and ovary. Proc Natl Acad Sci USA. 93:5925-5930.
34. Mosselman S, Polman J, Dijkema R. 1996 Identification and characterization of a novel human estrogen receptor. FEBS Lett. 392:49-53.
35. Levy C, Robel P, Gautray JP, et al. 1980 Estradiol and progesterone receptors in human endometrium: normal and abnormal menstrual cycles and early pregnancy. Am J Obstet Gynecol. 136:646-651.
36. Pulverer BJ, Hughes K, Franklin CC, Kraft AS, Leevers SJ, Woodgett JR. 1993 Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells. Oncogene. 8:407-415.
37. Yu W, Dahl G, Werner R. 1994 The connexin43 gene is responsive to oestrogen. Proc R Soc Lond B [Biol Sci] 255:125-132.
38. Claire-Wathes DC, Porter DG. 1982 Effect of uterine distension and oestrogen treatment on gap junction formation in myometrium of rat. J Reprod Fertil. 65:497-505.
39. Salmi A, Rutanen F-M. 1996 c-fos and c-jun expression in human endometrium and myometrium. Mol Cell Endocrinol. 117:233-240.
40. Nephew KP, Peters GA, Khan SA. 1995 Cellular localization of estradiol-induced c-fos messenger ribonucleic acid in the rat uterus: c-fos expression and uterine cell proliferation do not correlate strictly. Endocrinology. 136:3007-3015.
41. Hyder SM, Nawaz Z, Chiappetta C, Yokoyama K, Stancel GM. 1995 The Protooncogene c-jun contains an unusual estrogen-inducible enhancer within the coding sequence. J Biol Chem. 270:8506-8513.
42. Weisz A, Cicatiello L Persicot, E, Scalona M, Bresciani F. 1990 Estrogen stimulates transcription of c-jun protooncogene. Mol Endocrinol. 4:1041-1050.
43. Umayahara Y, Kawamori R, Watada H, et al. 1994 Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer. J Biol Chem. 269:16433-16442.
44. Gaub M-P, Bellard M, Scheuer I, Chambon P, Sassone-Corsi P. 1990 Activation of the ovalalbumin gene by the estrogen receptor involves the fos-jun complex. Cell. 63:1267-1276.
45. Pulkkinen M, Hämäläinen MM. 1995 Myometrial estrogen and progesterone receptor binding in pregnancy: inhibition by the detergent action of phospholipids. J Steroid Biochem Mol Biol. 52:287-294.
46. Perrot-Applanat M, Deng M, Fernandez H, Lelaidier C, Meduri G, Bouchard P. 1994 Immunohistochemical localization of estradiol and progesterone receptors in human uterus throughout pregnancy: expression in endometrial blood vessels. J Clin Endocrinol Metab. 78:216-224.
47. Yang-Yen H-F, Chambard J-C, Sun Y-L, Schmidt TJ, Drouin J, Karin M. 1990 Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell. 62:1205-1215.
48. Schüle R, Rangarajan P, Kliewer S, et al. 1990 Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell. 62:1217-1226.
49. Ambrosino C, Cicatiello L, Cobellis G, et al. 1993 Functional antagonism between the estrogen receptor and Fos in the regulation of c-fos protooncogene transcription. Mol Endocrinol. 7:1472-1483.
50. Casey LM, MacDonald PC. 1990 Endocrinology of pregnancy and parturition. In:Carsten ME, Miller JD, eds. Uterine function: molecular and cellular aspects, chapt 17. New York: Plenum Press; 501-517.