The Warthin-Finkeldey-type giant cell in HIV infection, what is it?

Ultrastructural Pathology

Volumn 22, Issue 4, 1998, Pages 293-303

  Orenstein, Jan Marc ^a,b  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Follicular dendritic cell; GI; HIV; Lymph node; Tonsil; Warthin Finkeldey giant cell

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 1 ANTITRYPSIN; ANTIGEN P24; CD3 ANTIGEN; CD45 ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C3D RECEPTOR; LYSOZYME; PROTEIN S 100; VIMENTIN; VIRUS RNA;

ADENOID; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DENDRITIC CELL; GIANT CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; LYMPH NODE HYPERPLASIA; MICROSCOPY; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; PRIORITY JOURNAL; TONSIL DISEASE; TRANSMISSION ELECTRON MICROSCOPY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0031732835     PISSN: 01913123     EISSN: None     Source Type: Journal    
DOI: 10.3109/01913129809103350     Document Type: Article

References (28)

1. Ewing EP, Chandler FW, Spira TJ, Brynes RK, Chan WC. Primary lymph node pathology in AIDS and AIDS-related lymphadenopathy. Arch Pathol Lab Med. 1985;109:977-981.
2. Domingo J, Chin NW. Lymphadenopathy in a heterogeneous population at risk for the acquired immune deficiency syndrome (AIDS): A morphologic study. Am J Clin Pathol. 1983;80:649-654.
3. Burns BF, Wood GF, Dorfman RF. The varied histopathology of lymphadenopathy in the homosexual male. Am J Surg Pathol. 1985;9:287-297.
4. Robbins FC. Measles: clinical features. Am J Dis Child. 1962;103:266-273.
5. Sherman FE, Ruckle G. In vivo and in vitro cellular changes specific for measles. Arch Pathol. 1958;65:587-599.
6. Delsol G, Pradere M, Voigt JJ, Nespoulous M, Gorguet B, Marty C, Fabre J. Warthin-Finkleday-like cells in benign and malignant lymphoid proliferations. Histopathology. 1982;6:451-465.
7. Kjeldsberg CR, Kim H. Polykaryoctyes resembling Warthin-Finkeldey giant cells in reactive and neoplastic lymphoid disorders. Hum Pathol. 1981;12:267-272.
8. Tajima M, Kudow S. Morphology of Warthin-Finkeldey giant cells in monkeys with experimentally induced measles. Acta Pathol Jpn. 1976;26:367-380.
9. Teute H, Braun R, Kirchner H, Becker H, Munk K. Replication of herpes simplex virus in human T lymphocytes. Intervirology 1983;20:32-41.
10. Kubota K, Tamura J, Kurabayashi H, Yanagisawa T, Shirakura T, Mori S. Warthin-Finkeldey-like giant cells in a patient with systemic lupus erythematosus. Hum Pathol. 1988;19:1358-1359.
11. Kamel OW, LeBrun DP, Berry GJ, Dorfman RF, Warnke RA. Warthin-Finkeldey polykaryocytes demonstrate a T-cell immunophenotype. Am J Clin Pathol. 1992;97:179-183.
12. Pekovic DD, Gornitsky M, Ajdukovic D, et al. Pathogenicity of HIV in lymphatic organs of patients with AIDS. J Pathol. 1987;152:31-35.
13. Sprenger R, Toellner K, Schmetz C, et al. Follicular dendritic cells productively infected with immunodeficiency viruses transmit infection to T cells. Med Microbiol Immunol. 1995;184:129-134.
14. Parmentier HK, van Wichen D, Sie-Go DMDS, Goudsmit J, Borleffs JCC, Schuurman H. HIV-1 infection and virus production in follicular dendritic cells in lymph nodes. Am J Pathol. 1990;137:247-251.
15. Tenner-Racz K, von Stemm AMR, Guhlk B, Schmitz J, Racz P. Are follicular dendritic cells macrophages and interdigitating cells of the lymphoid tissue productively infected by HIV? Res Virol. 1994;145:177-182.
16. Burke AP, Anderson D, Mannan P, et al. Systematic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome. Hum Pathol. 1994;25:248-256.
17. Orenstein JM, Fox C, Wahl SM. Macrophages as a source of HIV during opportunistic infections. Science. 1997;276:1857-1861.
18. Hui PK, Chan JKC, Ng CS, Kung ITM, Gwi E. Lymphadenopathy of Kumura's disease. Am J Surg Pathol. 1989;13:177-186.
19. Pinkus GS, Pinkus JL, Langhoff E, et al. Fascin, a sensitive new marker for Reed-Sternberg cells of Hodgkin's disease. Am J Pathol. 1997;150:543-562.
20. Wenig BM, Thompson LDR, Frankel SS, et al. Lymphoid changes of the nasopharyngeal and palatine tonsils that are indicative of human immunodeficiency virus infection. Am J Surg Pathol. 1996;20:572-587.
21. Spiegel H, Herbst H, Niedobitek G, Foss H, Stein H. Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4 + T-helper cells. Am J Pathol. 1992;140:15-22.
22. Liu Y, Grourard G, de Bouteiller O, Bancherearu J. Follicular dendritic cells and germinal centers. Int Rev Cytol. 1996;166:139-179.
23. Kamperdijk EWA, van Nieuwkerk EBJ, Arkema JM, Duijvestijn AM, Hoefsmit ECM. Macrophages and dendritic cells. In: Racz P, Dijkstra CD, Gluckman JC, eds. Accessory cells in HIV and Other Retroviral Infections. Basel: Karger; 1991;136-144.
24. Schriever F, Freedman AS, Freeman G, et al. Isolated human follicular dendritic cells display a unique antigenic phenotype. J Exp Med. 1989;169:2043-2058.
25. Schriever F, Nadler LM. The central role of follicular dendritic cells in lymphoid tissues. Adv Immunol. 1992;51:243-284.
26. Schinella RA, Muller WD, Greco MA. The lymph node in AIDS: a light microscopic and ultrastructural study. In: Rotterdam H, Racz P, Greco MA, Cockerell CJ, ed. Progress in AIDS Pathology, Vol. II. New York: Field & Wood Medical; 1990:13-23.
27. Imai Y, Maeda K, Yamakawa M, et al. Heterogeneity and cellular origin of follicular dendritic cells. In: Kamperdijk et al., eds. Dendritic Cells in Fundamental and Clinical Immunology. New York: Plenum; 1993;339-344.
28. Wacker H, Frahm SO, Heidebrecht HJ, Parwaresch R. Sinus-lining cells of the lymph nodes recognized as a dendritic cell type by the new monoclonal antibody Ki-M9. Am J Pathol. 1997;151:423-434.