Role of granulocyte colony stimulating factor in infection and inflammation

Medical Microbiology and Immunology

Volumn 187, Issue 2, 1998, Pages 61-69

  Hartung, Thomas ^a   Von Aulock, Sonja ^a   Wendel, Albrecht ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CLARITHROMYCIN; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 2; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ANTIINFLAMMATORY ACTIVITY; BACTEREMIA; BACTERIAL INFECTION; BONE PAIN; CLINICAL TRIAL; CYTOKINE RELEASE; HOST RESISTANCE; HUMAN; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKOCYTOSIS; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PERITONITIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY BURST; REVIEW; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME; VIRUS INFECTION; WOUND INFECTION;

ANIMALS; BACTERIAL INFECTIONS; CELLS, CULTURED; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INFLAMMATION; INTERFERONS; INTERLEUKINS; LEUKOCYTE COUNT; LEUKOCYTES; LEUKOCYTOSIS; LYMPHOCYTES; MONOCYTES; NEUTROPENIA; NEUTROPHILS;

EID: 0031731968     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004300050075     Document Type: Review

References (113)

1. Tamura M, Hattori K, Nomura H, Oheda M, Kubota N, Imazeki I, Ono M, Ueyama Y, Nagata S, Shirafuji N (1987) Induction of neutrophilic granulocytosis in mice by administration of purified human native granulocyte colony-stimulating factor (G-CSF). Biochem Biophys Res Commun 142: 454-460
2. Ulich TR, Castillo J del, Guo K, Souza L (1989) The hematologic effects of chronic administration of the monokines tumor necrosis factor, interleukin-1, and granulocyte-colony stimulating factor on bone marrow and circulation. Am J Pathol 134: 149-159
3. Cairo MS, Ven C van de, Toy C, Mauss D, Sheikh K, Kommareddy S, Modanlou H (1990) Lymphokines: enhancement by granulocyte-macrophage and granulocyte colony-stimulating factors of neonatal myeloid kinetics and functional activation of polymorphonuclear leukocytes. Rev Infect Dis 12 [Suppl]4: S492-497
4. Tkatch LS, Tweardy DL (1993) Human granulocyte colony-stimulating factor (G-CSF), the premier granulopoietin: biology, clinical utility, and receptor structure and function. Lymphokine Cytokine Res 12: 477-488
5. Lord BI, Molineux G, Pojda Z, Souza LM, Mermod JJ, Dexter TM (1991) Myeloid cell kinetics in mice treated with recombinant interleukin-3, granulocyte colony-stimulating factor (CSF), or granulocyte-macrophage CSF in vivo. Blood 77: 2154-2159
6. Gilmore GL, De Pasquale DK, Fischer BC, Shadduck RK (1995) Enhancement of monocytopoiesis by granulocyte colony-stimulating factor: evidence for secondary cytokine effects in vivo. Exp Hematol 23: 1319-1323
7. Morstyn G, Campbell L, Souza LM, Alton NK, Keech J, Green M, Sheridan W, Metcalf D, Fox R (1988) Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet I: 667-672
8. Bronchud MH, Potter MR, Morgenstern G, Blasco MJ, Scarffe JH, Thatcher N, Crowther D, Souza LM, Alton NK, Testa NG (1988) In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients. Br J Cancer 58: 64-69
9. Katoh M, Shirai T, Shikoshi K, Ishii M, Saito M, Kitagawa S (1992) Neutrophil kinetics shortly after initial administration of recombinant human granulocyte colony-stimulating factor: neutrophil alkaline phosphatase activity as an endogenous marker. Eur J Haematol 49: 19-24
10. Hartung T, Wendel A (1998) Immunomodulatory properties of Filgrastim (r-metHuG-CSF) in preclinical models. In: Morstyn G, Dexter G (eds) Filgrastim (r-metHuG-CSF) in clinical practice. Dekker, New York, pp 397-427
11. Hartung T, Döcke WD, Gantner F, Krieger G, Sauer A, Stevens P, Volk HD, Wendel A (1995) Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Blood 85: 2482-2489
12. Asano S, Shirafuji N, Watari K, Matsuda S, Uemura N, Ieki R, Kodo H, Takaku F (1988) Phase I clinical study for recombinant human granulocyte colony-stimulating factor. Behring Inst Mitt 83: 222-228
13. Kerrigan DP, Castillo A, Foucar K, Townsend K, Neidhart J (1989) Peripheral blood morphologic changes after high-dose antineoplastic chemotherapy and recombinant human granulocyte colony-stimulating factor administration. Am J Clin Pathol 92: 280-285
14. Demetri GD, Griffin JD (1991) Granulocyte colony-stimulating factor and its receptor. Blood 78: 2791-2808
15. Dührsen U, Villeval JL, Boyd J, Kannourakis G, Morstyn G, Metcalf D (1988) Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 72: 2074-2081
16. Matsumoto M, Matsubara S, Matsuno T, Tamura M, Hattori K, Nomura H, Ono M, Yokota T (1987) Protective effect of human granulocyte colony-stimulating factor on microbial infection in neutropenic mice. Infect Immun 55: 2715-2720
17. Ono M, Matsumoto M, Matsubara S, Tomioka S, Asano S (1988) Protective effect of human granulocyte colony-stimulating factor on bacterial and fungal infections in neutropenic mice. Behring Inst Mitt 83: 216-221
18. Uchida K, Yamamoto Y, Klein TW, Friedman H, Yamaguchi H (1992) Granulocyte-colony stimulating factor facilitates the restoration of resistance to opportunistic fungi in leukopenic mice. J Med Vet Mycol 30: 293-300
19. Hamood M, Bluche PF, De Vroey C, Corazza F, Bujan W, Fondu P (1994) Effects of recombinant human granulocyte-colony stimulating factor on neutropenic mice infected with Candida albicans: acceleration of recovery from neutropenia and potentiation of anti-C. albicans resistance. Mycoses 37: 93-99
20. Polak-Wyss A (1991) Protective effect of human granulocyte colony-stimulating factor (hG-CSF) on Cryptococcus and Aspergillus infections in normal and immunosuppressed mice. Mycoses 34: 205-215
21. Polak-Wyss A (1991) Protective effect of human granulocyte colony-stimulating factor (hG-CSF) on Candida infections in normal and immunosuppressed mice. Mycoses 34: 109-18
22. Steinshamn S, Bergh K, Waage A (1993) Effects of stem cell factor and granulocyte colony-stimulating factor on granulocyte recovery and Candida albicans infection in granulocytopenic mice. J Infect Dis 168: 1444-1448
23. Cairo MS, Mauss D, Kommareddy S, Norris K, Ven C van de, Modanlou H (1990) Prophylactic or simultaneus administration of recombinant human granulocyte colony stimulating factor in the treatment of group B streptococcal sepsis in neonatal rats. Pediatr Res 27: 612-616
24. Cairo MS, Plunkett JM, Mauss D, Ven C van de (1990) Seven-day administration of recombinant human granulocyte colony-stimulating factor to newborn rats: modulation of neonatal neutrophilia, myelopoiesis, and group B Streptococcus sepsis. Blood 76: 1788-1794
25. Cairo MS, Plunkett JM, Nguyen A, Ven C van de (1992) Effect of stem cell factor with and without granulocyte colony-stimulating factor on neonatal hematopoiesis: in vivo induction of newborn myelopoiesis and reduction of mortality during experimental group B streptococcal sepsis. Blood 80: 96-101
26. Iguchi K, Inoue S, Kumar A (1991) Effect of recombinant human granulocyte colony-stimulating factor administration in normal and experimentally infected newborn rats. Exp Hematol 19: 352-358
27. Novales JS, Salva AM, Modanlou HD, Kaplan DL, Castillo J del, Andersen J, Medlock ES (1993) Maternal administration of granulocyte colony-stimulating factor improves neonatal rat survival after a lethal group B streptococcal infection. Blood 81: 923-927
28. Dale DC (1994) Potential role of colony-stimulating factors in the prevention and treatment of infectious diseases. Clin Infect Dis 18 [Suppl 2]: S180-188
29. Roilides E, Pizzo PA (1993) Biologicals and hematopoietic cytokines in prevention or treatment of infectious in immunocompromised hosts. Infect Compl Immunocompromised Host 7: 841-864
30. Roilides E, Pizzo PA (1992) Modulation of host defenses by cytokines: evolving adjuncts in prevention and treatment of serious infections in immunocompromised hosts. Clin Infect Dis 15: 508-524
31. Gabrilove J (1992) The development of granulocyte colony-stimulating factor in its various clinical applications [editorial]. Blood 80: 1382-1385
32. Glaspy JA, Golde DW (1992) Granulocyte colony-stimulating factor (G-CSF): preclinical and clinical studies. Semin Oncol 19: 386-394
33. Hollingshead LM, Goa KL (1991) Recombinant granulocyte colony-stimulating factor (rG-CSF). A review of its pharmacological properties and prospective role in neutropenic conditions. Drugs 42: 300-330
34. Steward WP (1993) Granulocyte and granulocyte-macrophage colony-stimulating factors. Lancet 342: 153-157
35. Frampton JE, Yarker YE, Goa KL (1995) Lenograstim. A review of its pharmacological properties and therapeutic efficacy in neutropenia and related clinical settings. Drugs 49: 767-793
36. Dale DC, Liles WC, Summer WR, Nelson S (1995) Review: granulocyte colony-stimulating factor-role and relationships in infectious diseases. J Infect Dis 172: 1061-1075
37. Mooney DP, Gamelli RL, O'Reilly M, Hebert JC (1988) Recombinant human granulocyte colony-stimulating factor and Pseudomonas burn wound sepsis. Arch Surg 123: 1353-1357
38. Silver GM, Gamelli RL, O'Reilly M (1989) The beneficial effect of granulocyte colony-stimulating factor (G-CSF) in combination with gentamycin on survival after Pseudomonas burn wound infection. Surgery 106: 452-455; discussion 455-456
39. Sartorelli KH, Silver GM, Gamelli RL (19919 The effect of granulocyte colony-stimulating factor (G-CSF) upon burn-induced defective neutrophil chemotaxis. J Trauma 31: 523-529: discussion 529-530
40. Abraham E, Stevens P (1992) Effects of granulocyte colony-stimulating factor in modifying mortality from Pseudomonas aeruginosa pneumonia after hemorrhage. Crit Care Med 20: 1127-1133
41. Yasuda H, Ajiki Y, Shimozato T, Kasahara M, Kawada H, Iwata M, Shimizu K (1990) Therapeutic efficacy of granulocyte colony-stimulating factor alone and in combination with antibiotics against Pseudomonas aeruginosa infections in mice. Infect Immun 58: 2502-2509
42. O'Reilly M, Silver GM, Greenhalgh DG, Gamelli RL, Davis JH, Hebert JC (1992) Treatment of intra-abdominal infection with granulocyte colony-stimulating factor. J Trauma 33: 679-682
43. Goya T, Torisu M, Doi F, Yoshida T (1993) Effects of granulocyte colony stimulating factor and monobactam antibiotics (Aztreonam) on neutrophil functions in sepsis. Clin Immunol Immunopathol 69: 278-284
44. Toda H, Murata A, Matsuura N, Uda K, Oka Y, Tanaka N, Mori T (1993) Therapeutic efficacy of granulocyte colony stimulating factor against rat cecal ligation and puncture model. Stem Cells 11: 228-234
45. Lundblad R, Nesland JM, Giercksky KE (1996) Granulocyte colony-stimulating factor improves survival rate and reduces concentrations of bacteria, endotoxin, tumor necrosis factor, and endothelin-1 in fulminant intra-abdominal sepsis in rats. Crit Care Med 24: 820-826
46. Lorenz, W, Reimund KP, Weitzel F, et al. (1994) Granulocyte colony-stimulating factor prophylaxis before operation protects against lethal consequences of postoperative peritonitis. Surgery 116: 925-934
47. Barsig J, Bundschuh DS, Hartung T, Bauhofer A, Sauer A, Wendel A (1996) Control of fecal peritoneal infection in mice by colony-stimulating factors. J Infect Dis 174: 790-799
48. Dunne JR, Dunkin BJ, Nelson S, White JC (1996) Effects of granulocyte colony stimulating factor in a nonneutropenic rodent model of Esccherichia coli peritonitis. J Surg Res 61: 348-354
49. Eichacker PQ, Waisman Y, Natanson C, Farese A, Hoffmann WD, Banks SM, MacVittie TJ (1994) Cardiopulmonary effects of granulocyte colony-stimulating factor in a canine model of bacterial sepsis. J Appl Physiol 77: 2366-2373
50. Lazard T, Perronne C, Cohen Y, Grosset J, Vilde JL, Pocidalo JJ (1993) Efficacy of granulocyte colony-stimulating factor and RU-40555 in combination with clarithromycin against Mycobacterium avium complex infection in C57BL/6 mice. Antimicrob Agents Chemother 37: 692-695
51. Serushago BA, Yoshikai Y, Handa T, Mitsuyama M, Muramori K, Nomoto K (1992) Effect of recombinant human granulocyte colony-stimulating factor (rh G-CSF) on murine resistance against Listeria monocytogenes. Immunology 75: 475-480
52. Kayashima S, Tsuru S, Hata N, Rokutanda M (1993) Therapeutic effect of granulocyte colony-stimulating factor (G-CSF) on the protection against Listeria infection in SCID mice. Immunology 80: 471-476
53. Abramson JS, Hudnor HR (1994) Effect of priming polymorphonuclear leukocytes with cytokines (granulocyte-macrophage colony-stimulating factor [GM-CSF] and G-CSF) on the host resistance to Streptococcus pneumoniae in chinchillas infected with influenza A virus. Blood 83: 1929-1934
54. Lister PD, Gentry, MJ, Preheim LC (1993) Granulocyte colony-stimulating factor protects control rats but not ethanol fed rats from fatal pneumococcal pneumonia. J Infect Dis 168: 922-926
55. Nelson S, Summer W, Baghy G, Nakamura C, Stewart L, Lipscomb G, Andresen J (1991) Granulocyte colony-stimulating factor enhances pulmonary host defenses in normal and ethanol-treated rats. J Infect Dis 164: 901-906
56. Smith WS, Sumnicht GE, Sharpe RW, Samuelson D, Millard FE (1995) Granulocyte colony-stimulationg factor versus placebo in addition to penicillin G in a randomized blinded study of gram-negative pneumonia sepsis: analysis of survival and multisystem organ failure. Blood 86: 1301-1309
57. Freeman BD, Correa R, Karzai W, Natanson C, Patterson M, Banks S, Fitz Y, Danner RL, Wilson L, Eichacker PQ (1996) Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats. J Appl Physiol 80: 2066-2076
58. Daifuku T, Andresen J, Morstyn G (1993) Recombinant methionyl human granulocyte colony-stimulating factor for the prevention and treatment of non-neutrophenic infectious diseases. J Antimicrob Chemother 32 [Suppl A]: 91-97
59. Iida J, Saiki I, Ishihara C, Azuma I (1989) Protective activity of recombinant cytokines against Sendai virus and herpes simplex virus (HSV) infections in mice. Vaccine 7: 229-233
60. Azuma I, Ishihara C, Iida J, Yoo YC, Yoshimatsu K, Arikawa J (1992) Stimulation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice. Adv Exp Med Biol 319: 253-263
61. Gough A, Clapperton M, Rolando N, Foster AV, Philpott-Howard J, Edmonds ME (1997) Randomised placebo-controlled trial of granulocyte-colony stimulating factor in diabetic foot infection. Lancet 350: 855-859
62. Kuritzkes DR, Parenti D, Ward DJ, Rachlis A, Wong RJ, MolIon KP, Rich WP, Jacobson MA (1998) Filgrastim prevents severe neuropenia and reduces infective morbidity in patients with advanced HIV infection: results of a randomized, multicenter, controlled trial. AIDS 12: 65-74
63. Metcalf D (1987) The role of the colony-stimulating factors in resistance to acute infections. Immunol Cell Biol 65: 35-43
64. Vellenga E, Rambaldi A, Ernst TJ, Ostapovicz D, Griffin JD (1988) Independent regulation of M-CSF and G-CSF gene expression in human monocytes. Blood 71: 1529-1532
65. Hamilton JA, Whitty GA, Royston AK, Cebon J, Layton JE (1992) Interleukin-4 suppresses granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor levels in stimulated human monocytes. Immunology 76: 566-571
66. Sallerfors B, Olofsson T (1992) Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) secretion by adherent monocytes measured by quantitative immunoassays. Eur J Haematol 49: 199-207
67. Nelson S (1994) Role of granulocyte colony-stimulating factor in the immune response to acute bacterial infection in the nonneutropenic host: an overview. Clin Infect Dis 18 [Suppl 2]: S197-204
68. Dokter WH, Dijkstra AJ, Koopmans SB, Mulder AB, Stulp BK, Halie MR, Keck W, Vellenga E (1994) G(AnH)MTetra, a naturally occurring 1,6-anhydro muramyl dipeptide, induces granulocyte colony-stimulating factor expression in human monocytes: a molecular analysis. Infect Immun 62: 2953-2957
69. Kattorini L, Xiao Y, Li B, Santoro C, Ippoliti F, Orefici G (1994) Induction of IL-1 beta, IL-6, TNF-alpha, GM-CSF and G-CSF in human macrophages by smooth transparent and smooth opaque colonial variants of Mycobacterium avium. J Med Microbiol 40: 129-133
70. Lu L, Walker D, Graham CD, Waheed A, Shadduck RK, Broxmeyer HE (1988) Enhancement of release from MHC class II antigen-positive monocytes of hematopoietic colony stimulating factors CSF-1 and G-CSF by recombinant human tumor necrosis factor-alpha: synergism with recombinant human interferon-gamma. Blood 72: 34-41
71. Oster W, Lindemann A, Mertelsmann R, Herrmann F (1989) Granulocyte-macrophage colony-stimulating factor (CSF) and multilineage CSF recruit human monocytes to express granulocyte CSF. Blood 73: 64-67
72. Ishizaka Y, Motoyoshi K, Hatake K, Saito M, Takaku F, Miura Y (1986) Mode of action of human urinary colony-stimulating factor. Exp Hematol 14: 1-8
73. Motoyoshi K, Yoshida K, Hatake K, et al. (1989) Recombinant and native human urinary colony-stimulating factor directly augments granulocytic and granulocyte-macrophage colony-stimulaling factor production of human peripheral blood monocytes. Exp Hematol 17: 68-71
74. Seelentag WK, Mermod JJ, Montesano R, Vassalli P (1987) Additive effects of interleukin 1 and tumour necrosis factor-alpha on the accumulation of the three granulocyte and macrophage colony-stimulating factor mRNAs in human endothelial cells. EMBO J 6: 2261-2265
75. Zsebo KM, Yuschenkoff VN, Schiffer S, Chang D, McCall E, Dinarello CA, Brown MA, Altrock B, Bagby GC Jr (1988) Vascular endothelial cells and granulopoiesis. interleukin-1 stimulates release of G-CSF and GM-CSF. Blood 71: 99-103
76. Ichinose Y, Hara N, Ohta M, Aso H, Chikama H, Kawasaki M, Kubota I, Shimizu T, Yagawa K (1990) Recombinant granulocyte colony-stimulating factor and lipopolysaccharide maintain the phenotype of and superoxide anion generation by neutrophils. Infect Immun 58: 1647-1652
77. Lindemann A, Riedel C, Oster W, Ziegler-Heitbrock HV, Mertelsmann R, Herrmann F (1989) Granulocyte-macrophage colony-stimulating factor induces cytokine secretion by human polymorphonuclear leukocytes. J Clin Invest 83: 1308-1312
78. Lu L, Srour EF, Warren DJ, Walker D, Graham CD, Walker EB, Jansen J, Broxmeyer HE (1988) Enhancement of release of granulocyte-and granulocyte-macrophage colony-stimulating factors from phytohemagglutinin-stimulated sorted subsets of human T lymphocytes by recombinant human tumor necrosis factor-alpha. Synergism with recombinant human IFN-gamma. J Immunol 141: 201-207
79. Koeffler HP, Gasson J, Ranyard J, Souza L, Shepard M, Munker R (1987) Recombinant human TNF alpha stimulates production of granulocyte colony-stimulatign factor. Blood 70: 55-59
80. Koeffler HP, Gasson J, Tobler A (1988) Transcriptional and posttranscriptional modulation of myeloid colony-stimulating factor expression by tumor necrosis factor and other agents. Mol Cell Biol 8: 3432-3438
81. Seelentag W, Mermod JJ, Vassalli P (1989) Interleukin 1 and tumor necrosis factor-alpha additively increase the levels of granulocyte-macrophage and granulocyte colony-stimulating factor (CSF) mRNA in human fibroblasts. Eur J Immunol 19: 209-212
82. Furman WL, Lumm W, Arnold B, Pratt CB, Ihle JN (1992) Recombinant human TNF-alpha stimulates the secretion of granulocyte colony-stimulating factor in vivo. Leukemia 6: 319-322
83. Shannon MF, Coles LS, Fielke RK, Goodall GJ, Lagnado CA, Vadas MA (1992) Three essential promoter elements mediate tumour necrosis factor and interleukin-1 activation of the granulocyte-colony stimulating factor cene. Growth Factors 7: 181-193
84. Nelson S, Daifuku R, Andresen J (1994) Use of Filgrastim (r-metHu-G-CSF) in infectious diseases. In: Morstyn G, Dexter G (eds) Filgrastim in clinical practice. Dekker, New York, pp 253-266
85. Watari K, Asano S, Shirafuji N, Kodo H, Ozawa K, Takaku F, Kamachi S (1989) Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyine immunoassay. Blood 73: 117-122
86. Cheers C, Haigh AM, Kelso A, Metcalf D, Stanley ER, Young AM (1988) Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs. Infect Immun 56: 247-251
87. Cebon J, Layton JE, Maher D, Morstyn G (1994) Endogenous haemopoietic growth factors in neutropenia and infection. Br J Haematol 86: 265-274
88. Pauksen K, Elfman L, Ulfgren AK, Venge P (1994) Serum levels of granulocyte-colony stimulating factor (G-CSF) in bacterial and viral infections, and in atypical pneumonia. Br J Haematol 88: 256-260
89. Robins HI, Kutz M, Wiedemann GJ, Katschinski DM, Paul D, Grosen E, Tiggelaar CL, Spriggs D, Gillis W, d'Oleire F (1995) Cytokine induction by 41.8°C whole body hyperthermia. Cancer Lett 97: 195-201
90. Kawakami M, Tsutsumi H, Kumakawa T, Abe H, Hirai M, Kurosawa S, Mori M, Fukushima M (1990) Levels of serum granulocyte colony-stimulating factor in patients with infections. Blood 76: 1962-1964
91. Kawakami M, Tsutsumi H, Kumakawa T, Hirai M, Kurosawa S, Mori M, Fukushima M (1992) Serum granulocyte colony-stimulating factor in patients with repeated infections. Am J Hematol 41: 190-193
92. Tanaka H, Ishikawa K, Nishino M, Shimazu T, Yoshioka T (1996) Changes in granulocyte colony-stimulating factor concentration in patients with trauma and sepsis. J Trauma 40: 718-725; discussion 725-726
93. Lieschke GJ, Grail D, Hodgson G, Metcalf D, Stanley E, Cheers C, Fowler KJ, Basu S, Zhan YF, Dunn AR (1994) Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 84: 1737-1746
94. Layton JE, Hockman H, Sheridan WP, Morstyn G (1989) Evidence for a novel in vivo control mechanism of granulopoiesis: mature cell-related control of a regulatory growth factor. Blood 74: 1303-1307
95. Cairo MS (1993) Therapeutic implications of dysregulated colony-stimulating factor expression in neonates [editorial; comment]. Blood 82: 2269-2272
96. Görgen I, Hartung T, Leist M, Niehorster M, Tiegs G, Uhlig S, Weitzel F, Wendel A (1992) Granulocyte colony-stimulating factor treatment protects rodents against lipopolysaccharide-induced toxicity via suppression of systemic tumor necrosis factor-alpha. J Immunol 149: 918-924
97. Kitabayashi A, Hirokawa M, Hatano Y, Lee M, Kuroki J, Niitsu H, Miura AB (1995) Granulocyte colony-stimulating factor downregulates allogeneic immune responses by posttranscriptional inhibition of tumor necrosis factor-alpha production. Blood 86: 2220-2227
98. Aoki Y, Hiromatsu K, Kobayashi N, Hotta T, Saito H, Igarashi H, Niho Y, Yoshikai Y (1995) Protective effect of granulocyte colony-stimulating factor against T cell-mediated lethal shock triggered by superantigens. Blood 86: 1420-1427
99. Pan L, Delmonte J Jr, Jalonen CK, Ferrara JL (1995) Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease. Blood 86: 4422-4429
100. Vollmar B, Messner S, Wanner G, Hartung T, Menger MD (1997) Immunomodulatory action of G-CSF in a rat model of endotoxin-induced liver injury: a intravital microscopic analysis of Kupffer cell and leukocyte response. J Leukoc Biol 62: 710-718
101. Kanazawa M, Ishizaka A, Hasegawa N, Suzuki Y, Yokoyama T (1988) Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs. Am Rev Respir Dis 148: 1030-1035
102. Fink MP, O'Sullivan BP, Menconi MJ, Wollert SP, Wang H, Youssef ME, Bellelsle JM (1993) Effect of granulocyte colony-stimulating factor on systemic and pulmonary responses to endotoxin in pigs. J Trauma 34: 571-577; discussion 577-578
103. Hartung T, Volk H-D, Wendel A (1995) G-CSF - an anti-inflammatory cytokine. J Endotox Res 2: 195-201
104. Pajkrt D, Manten A, Poll T van der, Tiel-van Buul MM, Jansen J, Wouter ten Cate J, Deventer SJ van (1997) Modulation of cytokine release and neutrophil function by granulocyte colony-stimulating factor during endotoxemia in humans. Blood 90: 1415-1424
105. Chang JM, Metcalf D, Gonda TJ, Johnson GR (1989) Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice. J Clin Invest 84: 1488-1496
106. Denzlinger C, Holler E, Reisbach G, Hiller E, Wilmanns W (1994) Granulocyte colony-stimulating factor inhibits the endogenous leukotriene production in tumour patients. Br J Haematol 86: 881-882
107. Andresen J, Movahhed H, Nelson S (1998) Filgrastim (r-metHuG-CSF) in pneumonia. In: Morstyn G, Dexter G (eds) Filgrastim (r-metG-CSF) in clinical practice. Dekker, New York, pp 429-446
108. Foster PF, Mital D, Sankary HN, McChesney LP, Marcon J, Koukoulis G, Kociss K, Leurgans S, Whiting JF, Williams JW (1995) The use of granulocyte colony-stimulating factor after liver transplantation. Transplantation 59: 1557-1563
109. Endo S, Inada K, Inoue Y, Yamada Y, Takakuwa T., Kasai T, Nakae H, Kuwata Y, Hoshi S, Yashida M (1994) Evaluation of recombinant human granulocyte colony-stimulating factor (rhG-CSF) therapy in granulopoetic patients complicated with sepsis. Curr Med Res Opin 13: 233-241
110. Weiss M, Gross-Weege W, Schneider M, Neidhardt H, Liebert S, Mirow N, Wernet P (1995) Enhancement of neutrophil function by in vivo filgrastim treatment for prophylaxis of sepsis in surgical intensive care patients. J Crit Care 10: 21-26
111. Gross-Weege W, Weiss M, Schneider M, Wenning M, Harms B, Dumon K, Ohmann C, Roher HD (1997) Safety of a low-dosage Filgrastim (rhG-CSF) treatment in non-neutropenic surgical intensive care patients with an inflammatory process. Intensive Care Med 23: 16-22
112. Weiss M, Gross-Weege W, Harms B, Schneider EM (1996) Filgrastim (RHG-CSF) related modulation of the inflammatory response in patients at risk of sepsis or with sepsis. Cytokine 8: 260-265
113. Boisblanc BP de, Mason CM, Andresen J, Logan E, Bear MB, Johnson S, Shellito J, Summer WR, Nelson S (1997) Phase 1 safety trail of Filgrastim (r-metHuG-CSF) in non-neutropenic patients with severe community-acquired pneumonia. Respir Med 91: 387-394