Toxicological aspects of topical silver pharmaceuticals

Critical Reviews in Toxicology

Volumn 26, Issue 3, 1996, Pages 255-260

  Hollinger, Mannfred A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

iontophoresis; silver; toxicity; wound healing

Indexed keywords

SILVER; SILVER DERIVATIVE; SILVER NITRATE; SULFADIAZINE SILVER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARGYRIA; BURN; CONTROLLED STUDY; DRUG FORMULATION; DRUG MECHANISM; DRUG SYNTHESIS; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN CELL; INTRAUTERINE CONTRACEPTIVE DEVICE; IONTOPHORESIS; LEUKOPENIA; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; REVIEW; SKIN ABSORPTION; SUBCUTANEOUS DRUG ADMINISTRATION; TOPICAL DRUG ADMINISTRATION; WOUND HEALING;

ANIMALIA;

EID: 0030000110     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.3109/10408449609012524     Document Type: Review

References (57)

1. Goyer, R. A., Toxic effects of metals, in Casarett and Doull's Toxicology: The Basic Science of Poisons, Amdur, M. O., Doull, J., and Klassen, C. D., Eds., Pergamon, New York, 1991, 623-680.
2. Lewis, M., Worobe, J., Ramsay, D. S., and McCormack, M. K., Prenatal exposure to heavy metals: effect on childhood cognitive skills and health status, Pediatrics, 89, 1010, 1992.
3. Aberer, W., Holub, H., Strohal, R., and Slavieek, R., Palladium in dental alloys - the dermatologists' responsibility to warn?, Contact Derm., 28(3), 163, 1993.
4. Shall, L., Stevens, A., and Millard, L. G., An unusual case of acquired localized argyria, Br. J. Dermatol., 123, 403, 1990.
5. Rungby, J., Experimental argyrosis: ultrastructural localization of silver in rat eye, Exp. Mol. Pathol., 45(1), 22, 1986.
6. Greene, R. M. and Su, W. P., Argyria, Am. Fam. Physician, 36(6), 151, 1987.
7. Capoen, S. C., Boullie, M. C., and Mallet, E., Argyria in children, Arch. Fr. Pediatr., 46(1), 49, 1989.
8. Shelton, D. and Goulding, R., Silver poisoning associated with an antismoking lozenge, Br. Med. J., 1, 267, 1979.
9. Jensen, E. J., Rungby, J., Hansen, J. C., Schmidt, E., Pedersen, B., and Dahl, R., Serum concentrations and accumulation of silver in skin during three months treatment with an anti-smoking chewing gum containing silver acetate, Hum. Toxicol., 7(6), 535, 1988.
10. Mittag, H., Knecht, J., Arnold, R., Huttich, C., and Rupee, M., Argyria. A clinical, chemical analytic and micromorphologic study, Hautarzt, 38(11), 670, 1987.
11. 3, J. Dermatol., 21(1), 50, 1994.
12. Watanabe, K., Histopathological study of damage to peridontal tissues by silver alloy metals in rats, J. Jpn. Assoc. Periodontal., 31(4), 1021, 1989.
13. Fuller, F. W., Parrish, M., and Nance, F. C., A review of the dosimetry of 1% silver sulfadiazine cream in burn wound treatment, J. Burn Care Rehab., 15(3), 213, 1994.
14. Tsipouras, N., Rix, C. J., and Brady, P. H., Solubility of silver sulfadiazine in physiological media and relevance to treatment of thermal burns with silver sulfadiazine cream, Clin. Chem., 41(1), 87, 1995.
15. Boosalis, M. G., McCall, J. T., Ahrenholz, D. H., Solem, L. D., and McClain, C. J., Serum and urinary silver levels in thermal injury patients, Surgery, 101(1), 40, 1987.
16. Gamelli, R. L., Paxton, T. P., and O'Reilly, M., Bone marrow toxicity by silver sulfadiazine, Surg. Gynecol. Obstet., 177(2), 115, 1993.
17. Zapata-Sirvent, R. and Hansbrough, J. F., Cytotoxicity to human leukocytes by topical antimicrobial agents used for burn care, J. Burn Care Rehab., 14, 132, 1993.
18. Hussain, S., Anner, R. M., and Anner, B. M., Cysteine protects Na, K-ATPase and isolated human lymphocytes from silver toxicity, Biochem. Biophys. Res. Commun., 189(3), 1444, 1992.
19. Jansson, G. and Harms-Ringdahl, M., Stimulating effects of mercuric and silver ions on the superoxide anion production in human polymorphonuclear leukocytes, Free. Radic. Res. Commun., 18(2), 87, 1993.
20. McCauley, R. L., Linares, H. A., Pelligrini, V., Herndon, D. N., Robson, M. C., and Heggers, J. P., In vitro toxicity of topical antimicrobial agents to human fibroblasts, J. Surg. Res., 46(3), 267, 1989.
21. Kuroyanagi, Y., Kim, E., and Shioya, N., Evaluation of a synthetic wound dressing capable of releasing silver sulfadiazine, J. Burn Care Rehab., 12(2), 106, 1991.
22. Liedberg, H. and Lundeberg, T., Assessment of silver-coated urinary catheter toxicity by cell culture, Urol. Res., 17(6), 359, 1989.
23. Goldberg, R. L., Kaplan, S. R., and Fuller, G. C., Effect of heavy metals on human rheumatoid synovial cell proliferation and collagen synthesis, Biochem. Pharmacol., 32(18), 2763, 1983.
24. Wan, A. T., Conyers, R. A., Coombs, C. J., and Masterton, J. P., Determination of silver in blood, urine, and tissues of volunteers and burn patients, Clin. Chem., 37, 1683, 1991.
25. Rungby, J. and Ernst, E., Experimentally induced lipid peroxidation after exposure to chromium, mercury or silver: interactions with carbon tetrachloride, Pharmacol. Toxicol., 70(3), 205, 1992.
26. Shinogi, M. and Maeizumi, S., Effect of preinduction of metallothionein on tissue distribution of silver and hepatic lipid peroxidation, Biol. Pharmaceut. Bull., 16(4), 372, 1993.
27. Rungby, J., Hultman, P., and Ellermarnn-Erickson, S., Silver affects viability and structure of cultured mouse peritoneal macrophages and peroxidative capacity of whole mouse liver, Arch. Toxicol., 59(6), 408, 1987.
28. Baldi, C., Minoia, C., DiNuici, A., Capodaglio, E., and Manzo, L., Effects of silver in isolated rat hepatocytes, 41(3), 261, 1988.
29. Liu, J., Kershaw, W. C., and Klaasen, C. D., The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture, Toxicol. Appl. Pharmacol., 107(1), 27, 1991.
30. Shavlovski, M. M., Chebotar, N. A., Konopistseva, L. A., Zakharova, E. T., Kachourin, A. M., Vassiliev, V. B., and Gaitskhoki, V. S., Embryotoxicity of silver ions is diminished by ceruloplasmin - further evidence for its role in the transport of copper, Biometals, 8(2), 122, 1995.
31. Rungby, J., Slomianka, L., Danscher, G., Andersen, A. H., and West, M. J., A quantitative evaluation of the neurotoxic effect of silver on the volumes of the components of the developing rat hippocampus, Toxicology, 43(3), 261, 1987.
32. Rungby, J., An experimental study on silver in the nervous system and on aspects of its general cellular toxicity, Dan. Med. Bull., 37(5), 442, 1990.
33. Hultman, P., Enestrom, S., Turley, S. J., and Pollard, K. M., Selective induction of anti-fibrillarin autoantibodies by silver nitrate in mice, Clin. Exp. Immunol., 96(2), 285, 1994.
34. Steffensen, I. L., Mesha, O. J., Andruchow, E., Namork, E., Hylland, K., and Andersen, R. A., Cytotoxicity and accumulation of Hg, Ag, Cd, Pb, and Zn in human peripheral T and B lymphocytes and monocytes in vitro, Gen. Pharmacol., 25(8), 1621, 1994.
35. Leduc, S., Introduction of medicinal substances into the depth of tissues by electric current, Ann. Electrobiol., 3, 545, 1900.
36. Abramson, H. and Gorin, M., Skin permeability, Cold Spring Harb. Symp. Quant. Biol., 8, 272, 1940.
37. Rosendal, T., Studies on the conducting properties of the human skin to direct current, Acta Phys. Scand., 5, 130, 1942.
38. Edwards, D. A. and Langer, R., A linear theory of transdermal transport phenomena, J. Pharm. Sci., 83(9), 1315, 1994.
39. Chien, Y. M., Lelawongs, P., Siddiqui, O., Sun, Y., and Shi, W. M., Facilitated transdermal delivery of therapeutic peptides and proteins by iontophoretic delivery devices, J. Controll. Rel., 13, 263, 1990.
40. 21 esterified glucocorticoids: preliminary report, J. Am. Phys. Ther. Assoc., 43, 579, 1983.
41. Theiss, U., Kuhn, I., and Lucher, P. W., Iontophoresis - is there a future for clinical application?, Methods Find Exp. Clin. Pharmacol., 13, 353, 1991.
42. Chantraine, A., Ludy, J. P., and Berger, D., Is cortisone iontophoresis possible?, Arch. Phys. Med. Rehab., 67, 38, 1986.
43. Tyle, P., Iontophoretic devices for drug delivery, Pharmacol. Res., 3, 318, 1986.
44. Hall, R. E., Bender, G., and Marquis, R. E., In vitro effects of low intensity direct current generated silver on eukaryotic cells, J. Oral Maxillofac. Surg., 46(2), 128, 1988.
45. Fischer, G., Sayre, G. P., and Bickford, R. G., Histologic changes in the cat's brain after introduction of metallic and plastic coated wire used in electroencephalography, Proc. Mayo Clin., 32, 14, 1957.
46. Babb, T. L. and Kupfer, W., Phagocytic and metabolic reactions to chronically implanted metal brain electrodes, Exp. Neurol., 86(2), 171, 1984.
47. Jackson, W. F. and Duling, B. R., Toxic effects of silver-silver chloride electrodes on vascular smooth muscle, Circ. Res., 53, 105, 1983.
48. Lukanov, J. and Atmadjov, P., Investigating the effect of silver on the contractile function of smooth muscle preparation, Folia Med. (Plovdiv), 21, 11, 1979.
49. Cote, K. R. and Gill, R. C., Development of a platinized platinum/iridium electrode for use in vitro, Ann. Biomed. Eng., 15(5), 419, 1987.
50. Tanita, Y., Kato, T., Hanada, K., et al., Blue macules of localized argyria caused by implanted acupuncture needles. Electron microscopic and roentgenographic microanalysis of deposited metal, Arch. Dermatol., 121(12), 1550, 1985.
51. Phipps, J. B., Padmonabham, R. V., and Lattin, G. A., Iontophoretic delivery of model inorganic and drug ions, J. Pharm. Sci., 78(5), 365, 1989.
52. Maloney, J. M., Bezzant, J. L., Stephen, R. L., and Petelenz, T. J., Iontophoretic administration of lidocaine anesthesia in office practice, J. Dermatol. Surg. Oncol., 18, 937, 1992.
53. Cooper, C. F. and Jolly, W. C., Ecological effects of silver iodide and other weather modification agents: a review, Water Resources Res., 6, 98, 1970.
54. Klein, D. A., Environmental Impacts of Artificial Ice Nucleating Agents, Stroudburg, Dowden, Hutchinson and Ross, Inc., 1978, 63.
55. Petering, H. G., Pharmacology and toxicology of heavy metals: silver, Pharmacol. Ther., 1, 127, 1976.
56. Facts and Comparisons, St. Louis, MO, 1995, 561.
57. Singh, J. and Maibach, H. I., Topical iontophorelic drug delivery in vivo: historical development, devices and future perspectives, Dermatology, 187(4), 235, 1993.