Clinical trial experience using erythropoietin during radiation therapy

Strahlentherapie und Onkologie

Volumn 174, Issue SUPPL. 4, 1998, Pages 24-30

  Lavey, Robert S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Chemotherapy Hemoglobin Cancer; Erythropoietin; Oxygenation; Radiation therapy

Indexed keywords

ANTINEOPLASTIC AGENT; FERRITIN; FERROUS SULFATE; FLUOROURACIL; GRANULOCYTE COLONY STIMULATING FACTOR; HEMOGLOBIN; HYDROXYUREA; MITOMYCIN C; PACLITAXEL; RECOMBINANT ERYTHROPOIETIN;

ADULT; AGED; ANEMIA; ANIMAL MODEL; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONFERENCE PAPER; HEAD AND NECK CANCER; HEMOGLOBIN DETERMINATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG CANCER; NONHUMAN; ORAL DRUG ADMINISTRATION; PROGNOSIS; PROSTATE CANCER; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME; UTERINE CERVIX CANCER;

EID: 0031729893     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (15)

1. Dusenberg KE, McGuire WA, Holt PJ, et al. Erythropoietin increases hemoglobin during radiation therapy for cervical cancer. Int J Radiat Oncol Biol Phys 1994; 29:1079-84.
2. Eschbach JW, Egrie JC, Downing MR, et al. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and phase II clinical trial. N Engl J Med 1987;316: 73-8.
3. Girinski T, Pejovic-Lenfant MH, Bourhis J, et al. Prognostic value of hemoglobin concentrations and blood transfusions in advanced carcinoma of the cervix treated by radiation therapy: Results of a retrospective study of 386 patients. Int J Radiat Oncol Biol Phys 1989;16:37-42.
4. Glaser C, Millesi W, Gössweiner S, et al. r-HuErythropoietin supply increases efficacy of neoadjuvant radiochemotherapy in patients with oral squamous cell carcinoma. Proc ASCO 1998;17:397a.
5. Henry D, Mason B, Staddon A, et al. Efficacy of INFeD plus recombinant human erythropoietin (rHuEFO) in treating anemia in cancer patients with suboptimal response to rHuEPO: a pilot study. Proc ASCO 1998;17:59a.
6. Kelleher DK, Matthiensen U, Thews O, et al. Blood flow, oxygenation and bioenergetic status of tumors after erythropoietin treatment in normal and anemic rats. Cancer Res 1996;56:4728-34.
7. Lavey RS (Study Coordinator). Recombinant human erythropoietin (rHuEPO) as an adjunct to radiation therapy and cisplatin for patients with Stages II-B, III, and IV-A carcinoma of the cervix (SWOG-9318), Southwest Oncology Group.
8. Lavey RS, Dempsey WH. Erythropoietin increases hemoglobin is cancer patients during radiation therapy. Int J Radiat Oncol Biol Phys 1993;27: 1147-52.
9. Lavey RS, McBride WH. Influence of hematocrit on tumor oxygenation and sensitivity to radiation. Eur J Cancer 1993;29A(S6):S216.
10. Lee JS, Komaki R, Touroutoglou N, et al. Erythropoietin (EPO) prevents anemia during concurrent chemoradiation therapy (RT) for locally-advanced inoperable non-small cell lung cancer. Proc ASCO 1998;17:463a.
11. Rutherford CJ, Schneider TJ, Dempsey H, et al. Efficacy of different dosing regimens for recombinant human erythropoietin in a simulated perisurgical setting: The importance of iron availability in optimizing response. Am J Med 1994;96:139-45.
12. Tarnawski R, Skladowski K, Majiejewski, B. Prognostic value of hemoglobin concentration in radiotherapy for cancer of supraglottic larynx. Int J Radiat Oncol Biol Phys 1997;38:1007-11.
13. Thews O, Koenig R, Kelleher DK, et al. Enhanced radiosensitivity in experimental tumours following erythropoietin treatment of chemotherapy-induced anaemia. Br J Cancer 1998;78;752-6.
14. van Acht MJ, Herman J, Boks DE, et al. The prognostic value of hemoglobin and a decrease in hemoglobin during radiotherapy in laryngeal carcinoma. Radiother Oncol 1992;23:229-35.
15. Vijayakumar S, Roach M, Wara W et al. Effect of subcutaneous recombinant human erythropoietin in cancer patients receiving radiotherapy: preliminary results of a randomized, open-labeled, phase II trial. Int J Radiat Oncol Biol Phys 1993;56:721-9.