The polymorphic 43Thr bcl-2 protein confers relative resistance to autoimmunity: An analytical evaluation

Human Genetics

Volumn 103, Issue 4, 1998, Pages 435-440

  Komaki, Satoru ^a,e   Kohno, Michifumi ^b   Matsuura, Nobuo ^c   Shimadzu, Mitsunobu ^d   Adachi, Naoto ^a   Hoshide, Ryuuji ^a   Nishiyama, Soroku ^a   Matsuda, Ichiro ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b SAPPORO CITY GENERAL HOSPITAL   (Japan)

^c KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Mitsubishi Chemistry   (Japan)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; INTERLEUKIN 7; PROTEIN BCL 2; THREONINE;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CHILD; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTO ONCOGENE; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; APOPTOSIS; AUTOIMMUNE DISEASES; CELL LINE; CHILD; FEMALE; GENES, BCL-2; HUMANS; INTERLEUKIN-7; MALE; MICE; MIDDLE AGED; POLYMORPHISM, GENETIC; THREONINE; TRANSFECTION;

EID: 0031722940     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050847     Document Type: Article

References (28)

1. Aringer M, Wintersburger W, Steiner CW, Kiener H, Presterl E, Jaeger U, Smolen JS, Graninger WB (1994) High levels of bcl-2 protein in circulating T lymphocytes, but not B lymphocytes, of patients with systemic lupus erythematosus. Arthritis Rheum 37:1423-1430
2. Arnett FC, Edworthy SM, Bloch DA (1988) The American Rheuma- tism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324
3. Awata T, Kanazawa Y (1994) Genetic markers for insulin-dependent diabetes mellitus in Japanese. Diabetes Res Clin Pract 24 Suppl:S83-S87
4. Borzillo GV, Endo K, Tsujimoto Y (1992) Bcl-2 confers growth and survival advantage to interleukin-7-dependent early pre-B cells which become factor independent by multistep process in culture. Oncogene 7:869-876
5. Firestein GS, Yeo M, Zvaifler NJ (1995) Apoptosis in rheumatoid arthritis synovium. J Clin Invest 96:1631-1638
6. Galenby PA, Irvine M (1994) The bcl-2 proto-oncogene is over-expressed in systemic lupus erythematosus. J Autoimmun 7:623-631
7. Giordano C, Stassi G, Todaro M, De Maria R, Richiusa P, Scorsone A, Giordano M, Galluzzo A (1995) Low bcl-2 expression and increased spontaneous apoptosis in T-lymphocytes from newly-diagnosed IDDM patients. Diabetologia 38:953-958
8. Hartley SB, Cooke MP, Fulcher DA, Harris AW, Cory S, Basten A, Goodnow CC (1993) Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72:325-335
9. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336
10. Ikegami H, Kawaguchi Y, Yamato E, Kuwata S, Tokunaga K, Noma Y, Shima K, Ogihara T (1992) Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 75:1381-1385
11. Jacobson MD, Raff MC (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374:814-816
12. Linette GP, Grusby MJ, Hedrick SM, Hansen TH, Glimcher LH, Korsmeyer SJ (1994) Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1:197-205
13. McDonnel TJ, Deane N, Platt FM, Nunez G, Jaeger U, McKearn JP, Korsmeyer SJ (1989) Bcl-2 immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57:79-88
14. Mountz JD, Wu J, Cheng J, Zhou T (1994) Autoimmune disease. A problem of defective apoptosis. Arthritis Rheum 37:1415-1420
15. Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW (1996) X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381:335-341
16. Nakayama K, Nakayama K-I, Negishi I, Kuida K, Sawa H, Loh DY (1994) Targeted disruption of bcl-2αβ in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci USA 91:3700-3704
17. Nishimura Y, Thorsby E, Ronningen KS, Nelson LJ, Hansen JA, Bias WB, Faughet R, Dawkins RL, Tiilikainen A, Salvaneschi L, Martinetti M, Cuccia M, Vaughan RW, Hall M, Boehm BO, Juji T, Ohno S, Farid NR, Bodmer JG, Skamene E, Marsh DG, Svejgaard A, Thomsen AC, Sasazuki T (1991) General organization and overview of the disease component. In: Tsuji K, Aizawa M, Sasazuki T (eds) HLA 1991. Proceedings of the Eleventh International Histocompatibility Workshop and Conference, vol 1. Oxford Science, Oxford, pp 693-700
18. Rose LM, Latchman DS, Isenberg DA (1995) Bcl-2 expression is unaltered in unfractionated peripheral blood mononuclear cells in patients with systemic lupus erythematosus. Br J Rheumatol 34:316-320
19. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
20. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ (1991) Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879-888
21. Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y (1995) Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 374:811-813
22. Strasser A, Harris AW, Cory S (1991a) Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67:889-899
23. Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S, Harris AW (1991b) Enforced BCL-2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 88:8661-8665
24. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ (1982) The 1982 revised cri- teria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277
25. Thompson CJ (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462
26. Tsujimoto Y, Gorham J, Cossman J, Jaffe E, Croce CM (1985) The t(14;18) chromosome translocation involved in B-cell neoplasms results from mistakes in VDJ joining. Science 229:1390-1393
27. Veis DJ, Sentman CL, Bach EA, Korsmeyer SJ (1993) Expression of the Bcl-2 protein in murine and human thymocytes and peripheral T lymphocytes. J Immunol 151:2546-2554
28. Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM, Bjerrum KB, Braga S (1993) Preliminary criteria for the classification of Sjögren's syndrome. Arthritis Rheum 36:340-347