Reversed-phase high-performance liquid chromatography method for the simultaneous quantitation of the lactone and carboxylate forms of the novel natural product anticancer agent 10-hydroxycamptothecin in biological fluids and tissues

Journal of Chromatography B: Biomedical Applications

Volumn 686, Issue 2, 1996, Pages 257-265

  Li, Yu Feng ^a   Zhang, Ruiwen ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

10 Hydroxycamptothecin

Indexed keywords

10 HYDROXYCAMPTOTHECIN; DRUG METABOLITE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG FECES LEVEL; DRUG TISSUE LEVEL; DRUG URINE LEVEL; FLUORESCENCE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TECHNIQUE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LACTONES; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

EID: 0030588973     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00222-8     Document Type: Article

References (10)

1. [1] P. Pantazis, Clin. Cancer Res., 1 (1995) 1235.
2. [2] M.E. Wall, M.C. Wani, C.E. Cook, K.H. Palmer, A.T. McPhail and G.A. Sim, J. Am. Chem. Soc., 88 (1966) 3888.
3. [3] T.G. Burke and Z. Mi, Anal. Biochem., 212 (1993) 285.
4. [4] R. Han, Stem Cells, 12 (1994) 53.
5. [5] Y.-H. Ling, R. Perez-Soler and M.T. Tseng, Anticancer Res., 13 (1993) 1613.
6. [6] L.P. Rivory and J. Robert, J. Chromatogr. B, 661 (1994) 133.
7. [7] I. Barilero, J. Chromatogr., 575 (1992) 275.
8. [8] T.G. Burke and Z. Mi, J. Med. Chem., 37 (1994) 40.
9. [9] D.C. Scott, D.S. Bindra and V.J. Stella, Pharm. Res., 10 (1993) 1451.
10. [10] J.H. Beijnen, H. Rosing, W.W. ten Bokkel Huinink and H.M. Pinedo, J. Chromatogr., 617 (1993) 111.