Diltiazem modulates cyclosporin A induced renal hemodynamic effects but not its effect on plasma endothelin-1

Clinical Transplantation

Volumn 12, Issue 5, 1998, Pages 363-370

  Åsberg, Anders ^a,b,c   Christensen, Hege ^a   Hartmann, Anders ^b   Berg, Knut Joachim ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c Section of Nephrology   (Norway)

Author keywords

Cyclosporin A; Diltiazem; Endothelin 1; Renal function

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN A; DILTIAZEM; ENDOTHELIN 1; VASOCONSTRICTOR AGENT;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY GRAFT; KIDNEY TUBULE ABSORPTION; MALE; MEAN ARTERIAL PRESSURE; ORAL DRUG ADMINISTRATION; ORGAN PERFUSION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SLOW RELEASE FORMULATION; VASOCONSTRICTION;

ADULT; AGED; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CYCLOSPORINE; DILTIAZEM; ENDOTHELIN-1; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; RENAL CIRCULATION; VASOCONSTRICTION;

EID: 0031719774     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. PERICO N, RUGGENENTI P, GASPARI F, MOSCONI L, BENIGNI A, AMUCHASTEGUI CS, GASPARINI F, REMUZZI G. Daily renal hypoperfusion induced by cyclosporine in patients with renal transplantation. Transplantation 1992: 54: 56.
2. RUGGENENTI P, PERICO N, MOSCONI L, GASPARI F, BENIGNI A, AMUCHASTEGUI CS, BRUZZI I, REMUZZI G. Calcium channel blockers protect transplant patients from cyclosporine-induced daily renal hypoperfusion. Kidney Int 1993: 43: 706.
3. YANAGISAWA M, KURIHARA H, KIMURA S, TOMOBE Y, KOBAYASHI M, MITSUI Y, YAZAKI Y, GOTO K, MASAKI T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988: 332: 411.
4. BUNCHMAN TE, BROOKSHIRE CA. Cyclosporine-induced synthesis of endothelin by cultured human endothelial cells. J Clin Invest 1991: 88: 310.
5. PERNOW J, BOUTIER JF, FRANCO-CERECEDA A, LACROIX JS, MATRAN R, LUNDBERG JM. Potent selective vasoconstrictor effects of endothelin in the pig kidney in vivo. Acta Physiol Scand 1988: 134: 573.
6. KON V, SUGIURA M, INAGAMI T, HARVIE BR, ICHIKAWA I, HOOVER RL. Role of endothelin in cyclosporine-induced glomerular dysfunction. Kidney Int 1990: 37: 1487.
7. GRIEFF M, LOERTSCHER R, SHOHAIB SA, STEWART DJ. Cyclosporine-induced elevation in circulating endothelin-1 in patients with solid-organ transplants. Transplantation 1993: 56: 880.
8. SCHREINER GE. Determination of inulin by means of resorcinol. Proc Soc Exp Biol Med 1950: 74: 117.
9. SMITH HW, FINKELSEIN N, ALIMINOSE L, CRAWFORD B, GRABER M. The renal clearance of substituted hippuric acid derivate and other aromatic acids in dog and man. J Clin Invest 1945: 24: 388.
10. BERGAN S, RUGSTAD HE, STOKKE O, BENTDAL O, FROYSAKER T, BERGAN A. Cyclosporine A monitoring in patients with renal, cardiac, and liver transplants: a comparison between fluorescence polarization immunoassay and two different RIA methods. Scand J Clin Lab Invest 1993: 53: 471.
11. ASCALONE V, LOCATELLI M, MALAVASI B. Determination of diltiazem and its main metabolites in human plasma by automated solid-phase extraction and high-performance liquid chromatography: a new method overcoming instability of the compounds and interference problems. J Chromatogr B Biomed Appl 1994: 657: 133.
12. DE NICOLA L, LIBETTA C, MEMOLI B, BELLIZZI V, COLUCCI G, IMPERATORE P, TACCONE W, ORIENTE L, SEPE V, CONTE G. Acute renal and immunological effects of low-dose cyclosporin in humans. Nephrol Dial Transplant 1995: 10: 1739.
13. FUIANO G, SEPE V, CIANFRONE P, LIBETTA C, SABBATINI M, COLUCCI G, CONTE G, BALLETTA M, DE NICOLA L. Acute effects of low-dose cyclosporine on renal function in normal subjects. Transplantation 1991: 51: 734.
14. HANSEN JM, FOGH-ANDERSEN N, CHRISTENSEN NJ, STRANDGAARD S. Cyclosporine-induced hypertension and decline in renal function in healthy volunteers. J Hypertens 1997: 15: 319.
15. CONTE G, DAL CANTON A, SABBATINI M, NAPODANO P, DE NICOLA L, GIGLIOTTI G, FUIANO G, TESTA A, ESPOSITO C, Russo D, ANDREUCCI VE. Acute cyclosporine renal dysfunction reversed by dopamine infusion in healthy subjects. Kidney Int 1989: 36: 1086.
16. MUELLER EA, KOVARIK JM, VAN BREE JB, LISON AE, KUTZ K. Safety and steady-state pharmacokinetics of a new oral formulation of cyclosporine A in renal transplant patients. Transplant Int 1994: 7: 267.
17. KOVARIK JM, MUELLER EA, VAN BREE JB, FLUCKIGER SS, LANGE H, SCHMIDT B, BOESKEN WH, LISON AE, KUTZ K. Cyclosporine pharmacokinetics and variability from a microemulsion formulation-a multicenter investigation in kidney transplant patients. Transplantation 1994: 58: 658.
18. BARROS EJ, BOIM MA, AJZEN H, RAMOS OL, SCHOR N. Glomerular hemodynamics and hormonal participation on cyclosporine nephrotoxicity. Kidney Int 1987: 32: 19.
19. MYERS BD. Cyclosporine nephrotoxicity. Kidney Int 1986: 30: 964.
20. BERG KJ, HOLDAAS H, ENDRESEN L, FAUCHALD P, HARTMANN A, PRAN T, SOLBU D. Effects of isradipine on renal function in cyclosporin-treated renal transplanted patients. Nephrol Dial Transplant 1991: 6: 725.
21. FERGUSON C, WILIAMS J, HILLIS A, PARRY-JONES D, SALAMAN J. Effects of the calcium channel blocker diltiazem on cyclosporine nephrotoxicity in renal transplant patients. Clin Transplant 1992: 6: 391.
22. TORTORICE KL, HEIM-DUTHOY KL, AWNI WM, RAO KV, KASISKE BL. The effects of calcium channel blockers on cyclosporine and its metabolites in renal transplant recipients. Ther Drug Monit 1990: 12: 321.
23. PEDERSEN EB, MADSEN JK, SORENSEN SS, ZACHARIAE H. Improvement in renal function by felodipine during cyclosporine treatment in acute and short-term studies. Kidney Int Suppl 1996: 55: 94.
24. DIEPERINK H, LEYSSAC PP, STARKLINT H, JORGENSEN KA, KEMP E. Antagonist capacities of nifedipine, captopril. phenoxybenzamine, prostacyclin and indomethacin on cyclosporin A induced impairment of rat renal function. Eur J Clin Invest 1986: 16: 540.
25. PROPPER DJ, WHITING PH, MACKAY J, CATTO GR. Glomerulotubular function in long-term renal allograft recipients. A comparison of conventional therapy with cyclosporine. Transplantation 1990: 50: 72.
26. VINCENT HH, WENTING GJ, VERSLUIS DJ, WEIMAR W, SCHALEKAMP MA. Impaired fractional excretion of lithium: an early marker of cyclosporine-induced changes in renal hemodynamics. Transplant Proc 1988: 20: 681.
27. STURROCK ND, LANG CC, STRUTHERS AD. Indomethacin and cyclosporin together produce marked renal vasoconstriction in humans. J Hypertens 1994: 12: 919.
28. WAGNER OF, CHRIST G, WOJTA J, VIERHAPPER H, PARZER S, NOWOTNY PJ, SCHNEIDER B, WALDHAUSL W, BINDER BR. Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem 1992: 267: 16066.
29. KOHLHAW K, WONIGEIT K, FREI U, OLDHAFER K, NEU MANN K, PICHLMAYR R. Effect of the calcium channel blocker diltiazem on cyclosporine A blood levels and dose requirements. Transplant Proc 1988: 20: 572.
30. WALZ G, KUNZENDORF U, KELLER F, NEUMAYER H, OFFERMANN G. Cyclosporine blood levels in diltiazemtreated kidney graft recipients. Clin Transplant 1988: 2: 21.
31. BOURGE RC, KIRKLIN JK, NAFTEL DC, FIGG WD, WHITE-WILLIAMS C, KETCHUM C. Diltiazem-cyclosporine interaction in cardiac transplant recipients: impact on cyclosporine dose and medication costs. Am J Med 1991: 90: 402.
32. WAGNER K, HENKEL M, HEINEMEYER G, NEUMAYER HH. Interaction of calcium blockers and cyclosporine. Transplant Proc 1988: 20: 561.