Cyclosporine-induced hypertension and decline in renal function in healthy volunteers

Journal of Hypertension

Volumn 15, Issue 3, 1997, Pages 319-326

  Hansen, Jesper Melchior ^a,b   Fogh Andersen, Niels ^a   Christensen, Niels Juel ^a   Strandgaard, Svend ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Arterial blood pressure; Cyclosporine A; Glomerular filtration rate; Lithium clearance; Norepinephrine; Renal plasma flow; Sodium clearance

Indexed keywords

CYCLOSPORIN A; LITHIUM; NORADRENALIN; SODIUM;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY DISEASE; KIDNEY DISTAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE FUNCTION; KIDNEY VASCULAR RESISTANCE; MALE; MEAN ARTERIAL PRESSURE; NATRIURESIS; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SODIUM EXCRETION;

EID: 0030964413     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199715030-00014     Document Type: Article

References (37)

1. Chapman JR, Griffiths D, Harding NGL, Morris PJ: Reversibility of cyclosporine nephrotoxicity after three months treatment. Lancet 1985, i:128-130.
2. Curtis JJ, Luke RG, Dubovsky E, Diethelm AG, Whelchel JD, Jones P: Cyclosporin in therapeutic doses increases renal allograft vascular resistance. Lancet 1986, 2:477-479.
3. English J, Evan A, Houghton DC, Bennett WM: Cyclosporine-induced acute renal dysfunction in the rat. Transplantation 1987, 44:135-141.
4. Perico N, Ruggenenti P, Gaspari F, Mosconi L, Benigni A, Amuchastegui CS, et al.: Daily renal hypoperfusion induced by cyclosporine in patients with renal transplantation. Transplantation 1992, 54:56-60.
5. Hansen JM, Hoy CE, Strandgaard S: Fish oil and cyclosporin A-induced renal hypoperfusion in kidney transplanted patients. Nephrol Dial Transplant 1995, 10:1745-1750.
6. Curtis JJ, Luke RG, Jones P, Diethelm AG: Hypertension in cyclosporine-treated renal transplant recipients is sodium dependent. Am J Med 1988, 85:134-138.
7. Luke RG: Mechanism of cyclosporine-induced hypertension. Am J Hypertens 1991, 4:468-471.
8. Sturrock NDC, Lang CC, Baylis PH, Struthers AD: Sequential effects of cyclosporine therapy on blood pressure, renal function and neurohormones. Kidney Int 1994, 45:1203-1210.
9. Sturrock NDC, Lang CC, Struthers AD: Indomethacin and cyclosporin together produce marked renal vasoconstriction in humans. J Hypertens 1994, 12:919-924.
10. Sturrock NDC, Lang CC, Coutie WJ, Struthers AD: Cyclosporin-induced renal vasoconstriction is augmented by frusemide and by angiotensin II in humans. J Hypertens 1995, 13:987-991.
11. Garr MD, Paller MS: Cyclosporine augments renal but not systemic vascular reactivity. Am J Physiol 1990, 258:F211-F217.
12. Meyer-Lehnert H, Schrier RW: Potential mechanism for cyclosporine-induced vascular smooth muscle contraction. Hypertension 1989, 13:352-360.
13. Lamb FS, Webb RC: Cyclosporine augments reactivity of isolated blood vessels. Life Sci 1987, 40:2571-2578.
14. Christensen NJ, Vestergaard P, Sørensen T, Rafaelsen OJ: Cerebrospinal fluid adrenaline and noradrenaline in depressed patients. Acta Psychiatr Scand 1980, 61:178-182.
15. Thomsen K: Lithium clearance as a measure of sodium and water delivery from the proximal tubules. Kidney Int 1990, 37 (suppl 28):S10-S16.
16. Sirota JH, Baldwin DS, Villarreal H: Diurnal variations of renal function in man. J Clin Invest 1950, 29:187-192.
17. Conte G, Canton AD, Sabbatini M, Napodano P, Nicola LD, Gigliotti G, et al.: Acute cyclosporine renal dysfunction reversed by dopamine infusion in heathy subjects. Kidney Int 1989, 36:1086-1092.
18. Weir MR, Klassen DK, Shen SY, Sullivan D, Buddemeyer EU, Handwerger BS: Acute effects of intravenous cyclosporine on blood pressure, renal hemodynamics, and urine prostaglandin production of healthy humans. Transplantation 1990, 49:41-47.
19. De Nicola L, Libella C, Memoli B, Bellizi G, Colucci G, Imperatore P, et al.: Acute renal and immunological effects of low-dose cyclosporin in humans. Nephrol Dial Transplant 1995, 10:1739-1744.
20. Wahlberg J, Wilczek HE, Fauchald P, Nordahl KP, Heaf JG, Ølgaard K, et al.: Consistent absorption of cyclosporine from a microemulsion formulation assessed in stable renal transplant recipients over one-year study period. Transplantation 1995, 7:648-652.
21. Neumayer HH, Färber L, Haller P, Kohnen R, Maibücher A, Schuster A, et al.: Substitution of conventional cyclosporin with a new microemulsion formulation in renal transplant recipients: results after 1 year. Nephrol Dial Transplant 1996, 11:165-172.
22. Frei U, Taesch S, Niese D: Use of Sandimmun Neoral in renal transplant patients. Transplant Proc 1994, 26:2928-2931.
23. 2 receptor antagonists on cyclosporin A renal vasoconstriction. Am J Physiol 1994, 267:F443-F449.
24. Pavao Dos Santos OP, Boim MA, Bregman R, Draibe SA, Barros EJG, Pirotzky E, et al.: Effect of platelet-activating factor antagonist on cyclosporine nephrotoxicity. Transplantation 1989, 47:592-595.
25. Moss NG, Powell SL, Falk PJ: Intravenous cyclosporine activates afferent and efferent renal nerves and causes sodium retention in innervated kidneys in rats. Proc Natl Acad Sci USA 1985, 82:8222-8226.
26. Hansen JM, Abildgaard U, Fogh-Andersen N, Bratholm P, Plum I, Kanstrup IL, et al.: The transplanted human kidney does not achieve functional reinnervation. Clin Sci 1994, 87:13-20.
27. Scherrer U, Vissing SF, Morgan BJ, Rollins JA, Tindall RSA, Ring S, et al.: Cyclosporine-induced sympathetic activation and hypertension after heart transplantation. N Engl J Med 1990, 323:693-699.
28. Kaye D, Thompson J, Jennings G, Esler M: Cyclosporine therapy after cardiac transplantation causes hypertension and renal vasoconstriction without sympathetic activation. Circulation 1993, 88:1101-1109.
29. Stein CM, Huaibing H, Pincus T, Wood AJJ: Cyclosporine impairs vasodilation without increased sympathetic activity in humans. Hypertension 1995, 26:705-710.
30. Mason J, Müller-Schweinitzer E, Dupont M, Casellas D, Mihatsch M, Moore L, et al.: Cyclosporine and the renin-angiotensin system. Kidney Int 1991, 39 (suppl 32):S28-S32.
31. Bantle JP, Bourreau PJ, Ferns TF: Suppression of plasma renin activity by cyclosporine. Am J Med 1987, 83:59-65.
32. Bellet M, Cabrol C, Sassano P, Léger P, Corvol P, Ménard J: Systemic hypertension after cardiac transplantation: effect of cyclosporine on the renin-angiotensin-aldosterone system. Am J Cardiol 1985, 56:927-931.
33. Roullet JP, Xue H, McCarron DA, Holcomb S, Bennet WM: Vascular mechanisms of cyclosporin-induced hypertension in the rat. J Clin Invest 1994, 93:2244-2250.
34. Murray BM, Paller MS, Ferris TF: Effect of cyclosporine administration on renal hemodynamics in conscious rats. Kidney Int 1985, 28:767-774.
35. Textor SC, Smith-Powell L, Telles T: Altered pressor responses to NE and ANG II during cyclosporin A administration to conscious rats. Am J Physiol 1990, 258:H854-H860.
36. Rego A, Vargas R, Wroblewska B, Foegh ML, Ramwell PW: Attenuation of vascular relaxation and cyclic GMP responses by cyclosporin A. J Pharmacol Exp Ther 1990, 252:165-170.
37. Boer WH, Fransen R, Shirley DG, Walter SJ, Boer S, Koomans HA: Evaluation of the lithium clearance method: direct analysis of tubular lithium handling by micropuncture. Kidney Int 1995, 47:1023-1030.