Characterization of major surface glycoprotein genes of human Pneumocystis carinii and high-level expression of a conserved region

Infection and Immunity

Volumn 66, Issue 9, 1998, Pages 4268-4273

  Mei, Qin ^a,c   Turner, Ross E ^a   Sorial, Vivian ^a   Klivington, Diane ^a   William Angus, C ^a   Kovacs, Joseph A ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b MSC 1662 ^*  (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; CARBOXY TERMINAL SEQUENCE; GENE LIBRARY; IMMUNOBLOTTING; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

PNEUMOCYSTIS CARINII;

EID: 0031719252     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.9.4268-4273.1998     Document Type: Article

References (46)

1. Angus, C. W., A. Tu, P. Vogel, M. Qin, and J. A. Kovacs. 1996. Expression of variants of the major surface glycoprotein of Pneumocystis carinii. J. Exp. Med. 183:1229-1234.
2. 1a.Angus, C. W., et al. Unpublished data.
3. Burns, S. M., J. A. Read, P. L. Yap, and R. P. Brettle. 1990. Reduced concentrations of IgG antibodies to Pneumocystis carinii in HIV-infected patients during active Pneumocystis carinii infection and the possibility of passive immunisation. J. Infect. 20:33-39.
4. Davis, L. G., M. D. Dibne, and J. F. Battey. 1986. Basic methods in molecular biology. Elsevier, New York, N.Y.
5. Edman, J. C., U. Edman, M. Cao, B. Lundgren, J. A. Kovacs, and D. V. Santi. 1989. Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene. Proc. Natl. Acad. Sci. USA 86:8625-8629.
6. Edman, J. C., T. W. Hatton, M. Nam, R. Turner, Q. Mei, C. W. Angus, and J. A. Kovacs. 1996. A single expression site with a conserved leader sequence regulates variation of expression of the Pneumocystis carinii family of major surface glycoprotein genes. DNA Cell Biol. 15:989-999.
7. Elvin, K., A. Bjorkman, N. Heurlin, B. M. Eriksson, L. Barkholt, and E. Linden 1994. Seroreactivity to Pneumocystis carinii in patients with AIDS versus other immunosuppressed patients. Scand. J. Infect. Dis. 26:33-40.
8. Ezekowitz, R. A. B., D. J. Williams, H. Koziel, M. Y. K. Armstrong, A. Warner, F. F. Richards, and R. M. Rose. 1991. Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor. Nature 351:155-158.
9. Fisher, D. J., F. Gigliotti, M. Zauderer, and A. G. Harmsen. 1991. Specific T-cell response to a Pneumocystis carinii surface glycoprotein (gp120) after immunization and natural infection. Infect. Immun. 59:3372-3376.
10. Garbe, T. R., and J. R. Stringer. 1994. Molecular characterization of clustered variants of genes encoding major surface antigens of human Pneumocystis carinii. Infect. Immun. 62:3092-3101.
11. Gigliotti, F. 1992. Host species-specific antigen variation of a mannosylated surface glycoprotein of Pneumocystis carinii. J. Infect. Dis. 165:329-336.
12. Gigliotti, F., B. A. Garvy, and A. G. Harmsen. 1996. Antibody-mediated shift in the profile of glycoprotein A phenotypes observed in a mouse model of Pneumocystis carinii pneumonia. Infect. Immun. 64:1892-1899.
13. Gigliotti, F., and W. T. Hughes. 1988. Passive immunoprophylaxis with specific monoclonal antibody confers partial protection against Pneumocystis carinii pneumonitis in animal models. J. Clin. Investig. 81:1666-1668.
14. Haidaris, C. G., O. F. Medzihradsky, F. Gigliotti, and P. J. Simpson-Haidaris. 1998. Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A. DNA Res. 5:77-85.
15. Haidaris, P. J., T. W. Wright, F. Gigliotti, and C. G. Haidaris. 1992. Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii. J. Infect. Dis. 166:1113-1123.
16. Hofmann, B., N. Odum, P. Platz, L. P. Ryder, A. Svejgaard, P. B. Nielsen, W. Holten Andersen, J. Gerstoft, J. O. Nielsen, and M. Mojon. 1985. Humoral responses to Pneumocystis carinii in patients with acquired immunodeficiency syndrome and in immunocompromised homosexual men. J. Infect. Dis. 152:838-840.
17. Keely, S., H. J. Pai, R. Baughman, C. Sidman, S. M. Sunkin, J. R. Stringer, and S. L. Stringer. 1994. Pneumocystis species inferred from analysis of multiple genes. J. Eukaryot. Microbiol. 41:94S.
18. Kovacs, J. A., J. L. Halpern, B. Lundgren, J. C. Swan, J. E. Parrillo, and H. Masur. 1989. Monoclonal antibodies to Pneumocystis carinii: identification of specific antigens and characterization of antigenic differences between rat and human isolates. J. Infect. Dis. 159:60-70.
19. Kovacs, J. A., J. L. Halpern, J. C. Swan, J. Moss, J. E. Parrillo, and H. Masur. 1988. Identification of antigens and antibodies specific for Pneumocystis carinii. J. Immunol. 140:2023-2031.
20. Kovacs, J. A., F. Powell, J. C. Edman, B. Lundgren, A. Martinez, B. Drew, and C. W. Angus. 1993. Multiple genes encode the major surface glycoprotein of Pneumocystis carinii. J. Biol. Chem. 268:6034-6040.
21. Lugli, E. B., A. G. Allen, and A. E. Wakefield. 1997. A Pneumocystis carinii multi-gene family with homology to subtilisin-like serine proteases. Microbiology 143:2223-2236.
22. Lundgren, B., M. Lebech, K. Lind, J. O. Nielsen, and J. D. Lundgren. 1993. Antibody response to a major human Pneumocystis carinii surface antigen in patients without evidence of immunosuppression and in patients with suspected atypical pneumonia. Eur. J. Clin. Microbiol. Infect. Dis. 12:105-109.
23. Lundgren, B., G. Y. Lipscnik, and J. A. Kovacs. 1991. Purification and characterization of a major human Pneumocystis carinii surface antigen. J. Clin. Investig. 87:163-170.
24. Lundgren, B., J. D. Lundgren, T. Nielsen, L. Mathiesen, J. O. Nielsen, and J. A. Kovacs. 1992. Antibody responses to a major Pneumocystis carinii antigen in human immunodeficiency virus-infected patients with and without P. carinii pneumonia. J. Infect. Dis. 165:1151-1155.
25. Mei, Q., J. A. Kovacs, B. Hildebrand, and C. W. Angus. 1996. Expression of the major surface glycoprotein of rat-derived Pneumocystis carinii by recombinant baculovirus. J. Eukaryot. Microbiol. 43:31S.
26. Meuwissen, J. H., I. Tauber, A. D. Leeuwenberg, P. J. Beckers, and M. Sieben. 1977. Parasitologic and serologic observations of infection with Pneumocystis in humans. J. Infect. Dis. 136:43-49.
27. Peglow, S. L., A. G. Smulian, M. J. Linke, C. L. Pogue, S. Nurre, J. Crisler, J. Phair, J. W. M. Gold, D. Armstrong, and P. D. Walzer. 1990. Serologic responses to Pneumocystis carinii antigens in health and disease. J. Infect. Dis. 161:296-306.
28. Posnett, D. N., H. McGrath, and J. P. Tam. 1988. A novel method for producing anti-peptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain. J. Biol. Chem. 263:1719-1725.
29. Pottratz, S. T., J. Paulsrud, J. S. Smith, and W. J. Martin II. 1991. Pneumocystis carinii attachment to cultured lung cells by pneumocystis gp120, a fibronectin binding protein. J. Clin. Investig. 88:403-407.
30. Radding, J. A., M. Y. K. Armstrong, E. Ullu, and F. F. Richards. 1989. Identification and isolation of a major cell surface glycoprotein of Pneumocystis carinii. Infect. Immun. 57:2149-2157.
31. + T cells into severe combined immunodeficiency mice. J. Clin. Investig. 90:673-678.
32. Russian, D. A., V. Andrawis-Sorial, J. C. Edman, P. Vogel, R. E. Turner, D. L. Klivington, C. W. Angus, and J. A. Kovacs. 1997. Identification and characterization of novel surface expressed serine protease variants encoded by a multicopy gene family in Pneumocystis carinii, abstr. O31. In Abstracts of the 5th International Workshops on Opportunistic Protists and 5th General Meeting of the European Concerted Action on Pneumocystis Research.
33. Smulian, A. G., D. W. Sullivan, M. J. Linke, N. A. Halsey, T. C. Quinn, A. P. MacPhail, M. A. Hernandez Avila, S. T. Hong, and P. D. Walzer. 1993. Geographic variation in the humoral response to Pneumocystis carinii. J. Infect. Dis. 167:1243-1247.
34. Stringer, J. R. 1993. The identity of Pneumocystis carinii: not a single protozoan, but a diverse group of exotic fungi. Infect. Agents Dis. 2:109-117.
35. Stringer, S. L., T. Garbe, S. M. Sunkin, and J. R. Stringer. 1993. Genes encoding antigenic surface glycoproteins in Pneumocystis from humans. J. Eukaryot. Microbiol. 40:821-826.
36. Sunkin, S. M., and J. R. Stringer. 1996. Translocation of surface antigen genes to a unique telomeric expression site in Pneumocystis carinii. Mol. Microbiol. 19:283-295.
37. Tanabe, K., S. Takasaki, J. Watanabe, A. Kobata, K. Egawa, and Y. Nakamura. 1989. Glycoproteins composed of major surface immunodeterminants of Pneumocystis carinii. Infect. Immun. 57:1363-1368.
38. Theus, S. A., R. P. Andrews, M. J. Linke, and P. D. Walzer. 1997. Characterization of rat CD4 T cell clones specific for the major surface glycoprotein of Pneumocystis carinii. J. Eukaryot. Microbiol. 44:96-100.
39. Theus, S. A., R. P. Andrews, P. Steele, and P. D. Walzer. 1995. Adoptive transfer of lymphocytes sensitized to the major surface glycoprotein of Pneumocystis carinii confers protection in the rat. J. Clin. Investig. 95:2587-2593.
40. Theus, S. A., M. J. Linke, R. P. Andrews, and P. D. Walzer. 1993. Proliferative and cytokine responses to a major surface glycoprotein of Pneumocystis carinii. Infect. Immun. 61:4703-4709.
41. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
42. Wada, M., K, Kitada, M. Saito, K. Egawa, and Y. Nakamura. 1993. cDNA sequence diversity and genomic clusters of major surface giycoprotein genes of Pneumocystis carinii. J. Infect. Dis. 168:979-985.
43. Wada, M., and Y. Nakamura. 1996. Unique telomeric expression site of major-surface-glycoprotein genes of Pneumocystis carinii. DNA Res. 3:55-64.
44. Wada, M., S. M. Sunkin, J. R. Stringer, and Y. Nakamura. 1995. Antigenic variation by positional control of major surface glycoprotein gene expression in Pneumocystis carinii. J. Infect. Dis. 171:1563-1568.
45. Wright, T. W., T. Y. Bissoondial, C. G. Haidaris, F. Gigliotti, and P. J. Haidaris. 1995. Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii. DNA Res. 2:77-88.
46. Zimmerman, P. E., D. R. Voelker, F. X. McCormack, J. R. Paulsrud, and W. J. Martin II. 1992. 120-kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein. A. J. Clin. Inveslig. 89:143-149.