Ultrastructural and biochemical evidence of apoptosis induced by a novel inhibitor of protein geranylgeranylation in human MIA PaCa-2 pancreatic cancer cells

Ultrastructural Pathology

Volumn 22, Issue 3, 1998, Pages 253-261

  Gesi, Marco ^a   Pellegrini, Antonio ^a   Soldani, Paola ^a   Lenzi, Paola ^a   Paparelli, Antonio ^a   Danesi, Romano ^a   Nardini, Denise ^a   Macchia, Marco ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Apoptosis; DNA fragmentation; Electron microscopy; Programmed cell death; Protein geranylgeranylation

Indexed keywords

ENZYME INHIBITOR; GERANYLTRANSFERASE;

APOPTOSIS; ARTICLE; ENZYME INHIBITION; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

AGOUTI PACA; OXY;

EID: 0031719196     PISSN: 01913123     EISSN: None     Source Type: Journal    
DOI: 10.3109/01913129809033477     Document Type: Article

References (12)

1. Grimier J, Ericsson J, Dallner G. Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins. Biochim Biophys Acta. 1994;1212:259-277.
2. Giannakouros T, Magee AI. Protein prenylation and associated modifications. In: Schlesinger MJ ed. Lipid Modifications of Proteins. London: CRC Press; 1993:136-162.
3. Rodenhuis S. Ras and human tumors. Semin Cancer Biol. 1992;3:214-247.
4. Gibbs BJ, Oliff A, Kohl N. Farnesyltransferase inhibitors: ras research yields a potential cancer therapeutic. Cell. 1994;77:175-178.
5. 1. Science. 1995;269:1270-1272.
6. Macchia M, Jannitti N, Gervasi G, Danesi R. Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins. J Med Chem. 1996;39:1352-1356.
7. Kawabat H, Anzai N, Yoshida Y, Okuma M. A new method for quantitative estimation of the degree of DNA fragmentation utilizing agarose gel electrophoresis. Int J Hematol. 1994;15:539-547.
8. Ross WD. Apoptosis. Arch Pathol Lab Med. 1997;121:83.
9. Pérez-Sala D, Mollinedo F. Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells. Biochem Biophys Res Commun. 1994;199:1209-1215.
10. Pérez-Sala D, Collado-Escobar D, Mollinedo F. Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J Biol Chem. 1995;270:6235-6242.
11. Gorczyca W, Gong J, Ardelt B, Traganos F, Darzynkiewicz Z. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 1993;53:3186-3192.
12. 2-M Enrichment in A549 cells. Cancer Res. 1997;57:1846-1850.