High serum luteinizing hormone levels induce ovarian Δ4 cytochrome P450c17α down-regulation in hirsute women: Complete effect on 17-hydroxylase and partial effect on 17,20-lyase

European Journal of Endocrinology

Volumn 139, Issue 3, 1998, Pages 304-308

  Rieu, Max ^a,c   Mourrieras, Florence ^a   Riveline, Jean Pierre ^a   Laplanche, Sophie ^a   Both, Dominique ^a   Kuhn, Jean Marc ^b  

^a Hospital Saint Michel   (France)

^b Dept de Médecine Interne Ctr Hosp Univ Rouen Boisguillaume   (France)

^c Hopital Saint Michel   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; CAMPHOR 5 MONOOXYGENASE; CORTICOTROPIN; CYTOCHROME P450; LUTEINIZING HORMONE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE;

ADULT; ARTICLE; ENZYME ANALYSIS; FEMALE; HIRSUTISM; HORMONE DETERMINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; STATISTICAL ANALYSIS;

17-ALPHA-HYDROXYPROGESTERONE; ADULT; ANDROSTENEDIONE; BODY MASS INDEX; DOWN-REGULATION; FEMALE; HIRSUTISM; HUMANS; LUTEINIZING HORMONE; OVARY; RADIOIMMUNOASSAY; STEROID 17-ALPHA-HYDROXYLASE; TESTOSTERONE;

EID: 0031716254     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1390304     Document Type: Article

References (25)

1. Erickson GF, Magoffin DA, Dyer CA & Hofeditz C. The ovarian androgen producing cells: a review of structure/function relationships. Endocrine Reviews 1985 6 371-399.
2. Richards JS & Hedin L. Molecular aspects of hormone action in ovarian follicular development, ovulation, and luteinization. Annual Review of Physiology 1988 50 441-463.
3. Magoffin DA. Evidence that luteinizing hormone-stimulated differentiation of purified ovarian thecal-interstitial cells is mediated by both type I and type II adenosine 3′,5′-monophosphate-dependent protein kinase. Endocrinology 1989 125 1464-1473.
4. Hu ZZ. Tsai-Morris CH, Buczko E & Dufau ML. Hormonal regulation of LH receptor mRNA and expression in the rat ovary. FEBS Letters 1990 274 181-184.
5. Yen SSC. Gonadotropic hormones: biosynthesis, secretion, receptors, and actions. In Reproductive Endocrinology: Physiology, Pathophysiology and Clinical Management, pp 105-155. Eds SSC Yen & RB Jaffe. Philadelphia: WB Saunders, 1991.
6. Lieberman ME, Barnea A, Bauminger S, Tsafriri A, Collins WP & Lindner HR. LH effect on the pattern of steroidogenesis in cultured Graafian follicles of the rat: dependence on macromolecular synthesis. Endocrinology 1974 96 1533-1542.
7. 1 in the rabbit. Endocrinology 1976 99 185-197.
8. Hillensjö T, Hamberger L & Ahren K. Effect of androgens on the biosynthesis of estradiol-17β by isolated periovulatory rat follicles. Molecular and Cellular Endocrinology 1977 9 183-193.
9. Conti M, Harwood JP, Dufau ML & Catt KJ. Effect of gonadotropin-induced receptor regulation on biological responses of isolated rat luteal cells. Journal of Biological Chemistry 1977 252 8869-8874.
10. Rajaniemi HJ, Ronnberg L, Kaupilla A, Ylostalo P & Vihko, R. Luteinizing hormone receptors in ovarian follicles of patients with polycystic ovarian disease. Journal of Clinical Endocrinology and Metabolism 1980 51 1054-1057.
11. Dufau MO, Winters CA, Hattori M, Aquilano D, Baranao JL, Nozu et al. Hormonal regulation of androgen production by the Leydig cell. Journal of Steroid Biochemistry and Molecular Biology 1984 20 161-173.
12. Cara JF, Azzarello J & Rosenfield RL. Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian thecainterstitial cells. Journal of Clinical Investigation 1990 86 560-565.
13. Lamprecht SA, Zor U, Salomon Y, Koch Y, Ahern K & Lindner H. Mechanism of hormonally induced refractoriness of ovarian adenylate cyclase to luteinizing hormone and prostaglandin. European Journal of Cyclic Nucleotide Research 1977 3 69-83.
14. Eckstein B, Greenbaum O & Cohen S. Kinetic studies on ovarian C-17,20-lyase activity: effect of luteinizing hormone surge. Endocrinology 1985 117 2376-2382.
15. Gilling-Smith C, Willis DS, Beard RW & Franks S. Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries. Journal of Clinical Endocrinology and Metabolism 1994 79 1158-1165.
16. Saez JM & Forest MG. Kinetics of human chorionic gonadotropin-induced steroidogenic response of the human testis. I. Implications for human chorionic gonadotropin stimulation test. Journal of Clinical Endocrinology and Metabolism 1979 49 278-283.
17. Rieu M, Reznik Y, Vannetzel JM, Mahoudeau J, Berrod JL & Kuhn JM. Testicular steroidogenesis in adult men with human chorionic gonadotropin-producing tumors. Journal of Clinical Endocrinology and Metabolism 1995 80 2404-2409.
18. New MI, Lorenzen F & Lerner AJ. Genotyping steroid 21-hydroxylase deficiency: hormonal reference data. Journal of Clinical Endocrinology and Metabolism 1983 57 320-326.
19. Lanzone A, Fulghesu AM, Guido M, Fortini A, Caruso A & Mancuso S. Differential androgen response to adrenocorticotropic hormone stimulation in polycystic ovarian syndrome: relationship to insulin secretion. Fertility and Sterility 1992 58 296-301.
20. Azziz R, Boots LR, Parker Jr CR, Bradley Jr E & Zacur HA. 11β-Hydroxydehydrogenase deficiency in hyperandrogenism. Fertility and Sterility 1991 55 733-741.
21. Azziz R, Bradley Jr EL, Potter HD & Boots LR. 3β-Hydroxydehydrogenase deficiency in hyperandrogenism. American Journal of Obstetrics and Gynecology 1993 168 895-899.
22. Kuhn JM, Duranteau L, Rieu M, Lahlou N, Roger M & Luton JP. Evidence of oestradiol-induced changes in gonadotropin secretion in men with feminizing Leydig cell tumours. European Journal of Endocrinology 1994 131 160-166.
23. Rosenfield RL, Barnes RB, Cara JF & Lucky AW. Dysregulation of cytochrome P450c17α as the cause of polycystic ovarian syndrome. Fertility and Sterility 1990 53 785-791.
24. Ehrmann DA, Barnes RB & Rosenfield RL. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocrine Review 1995 16 322-369.
25. Morales AJ, Laughlin GA, Bützow T, Maheshwari H, Baumann G & Yen SSC. Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features. Journal of Clinical Endocrinology and Metabolism 1996 81 2854-2864.