Neuropeptides exert direct effects on rat thymic epithelial cells in culture

Developmental Immunology

Volumn 6, Issue 1-2, 1998, Pages 95-104

  Head, Gail M ^a   Mentlein, R ^b   Von Patay, Birte ^b   Downing, J E G ^a   Kendall, Marion D ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Kiel and Lungen Clinic Grosshansdorf   (Germany)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Gap junctions; Multinucleate cells; Neuropeptides; Proliferation; Thymic epithelial cells; Thymulin

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; CALCITONIN GENE RELATED PEPTIDE; HISTAMINE; ISOPRENALINE; LUCIFER YELLOW; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROTRANSMITTER; SEROTONIN; SUBSTANCE P; THYMULIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; CELL COMMUNICATION; CELL CULTURE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; THYMOCYTE;

ANIMALIA;

EID: 0031715550     PISSN: 10446672     EISSN: None     Source Type: Journal    
DOI: 10.1155/1998/41349     Document Type: Conference Paper

References (39)

1. Al-Shawaf A., Cowen T., and Kendall M.D. (1991). Identification of neural profiles containing vasoactive intestinal polypeptide, acetylcholinesterase and catecholamines in the rat thymus. J. Anat. 174: 131-143.
2. Alves L.A., Compos de Carvalho A.C., Lima E.O.C., Souza C.M.R.e, Dardenne M., Spray D.C., and Savino W. (1995). Functional gap junctions in thymic epithelial cells are formed by connexin 43. Eur. J. Immunol. 25: 431-437.
3. Alves L.A., Compos de Carvalho A.C., Parreira-Martins L., Dardenne M., and Savino W. (1994). Intrathymic gap junction-mediated communication. In In vivo Immunology, Heinen E., Defresne M.P., Boniver J., and Geenen V., Eds. (New York: Plenum).
4. Buckingham J.C., Safieh B., Singh S., Arduino L.A., Cover P.O., and Kendall M.D. (1992). Interactions between the hypothalamo-pituitary adrenal axis and the thymus in the rat: A role for corticotrophin in the control of thymulin release. J. Neuroendocrin. 4: 295-301.
5. Combettes L., Tran D., Tordjmann T., Laurent M., Berthon B., and Claret M. (1994). Ca2+-mobilizing hormones induce sequentially ordered Ca2+ signals in multicellular systems of rat hepatocytes. Biochem. J. 304: 585-594.
6. Demello W.C., and Maldonado U. (1985) Synaptic inhibition and cell communication - impairment of cell-to-cell coupling produced by gamma-aminobutyric acid (GABA) in the somatic musculature of Ascaris lumbricoides. Cell Biol. Int. Rep. 9: 803-813.
7. Felten D.L., and Felten S.Y. (1989). Innervation of the thymus. Thymus Update 2: 73-88.
8. Felten D.L., Felten S.Y., Carlson S.L., Olshowka J.A., and Livnat S. (1985). Noradrenergic and peptidergic innervation in lymphoid tissue. J. Immunol. 135: 7555-7655.
9. Gibson D.F., Hossain M.Z., Goldberg G.S., Acevedo P., and Bertram J.S. (1994). The mitogenic effects of transforming growth factor beta 1 and factor beta 2 in C3H10T1/2 cells occur in the presence of enhanced gap junctional communication. Cell Growth Diff. 5: 687-696.
10. Head G.M., Kranz A., and Kendall M.D. (1996a). The dye coupling of rat thymic epithelial cells in culture. J. Anat. 189: 227-228.
11. Head G.M., Kranz A., Kendall M.D., and Downing J.E.G. (1996b). Proliferation and dye coupling in cultured rat thymic epithelial cells. J. Physiol. 493P: 63P-64P.
12. Head G.M., Mentlein R., Kranz A., Downing J.E.G., and Kendall M.D. (1997). Modulation of dye-coupling in cultured rat thymic epithelium by factors involved in thymulin secretion. J. Anat. 191: 355-365.
13. Lampert I.A., and Ritter M.A. (1988). The origin of the diverse epithelial cells of the thymus: Is there a common stem cell? Thymus Update 1: 5-25.
14. Kampinga J., Berges S., Boyd R.L., Brekelmans P., Colic M., van Ewijk W., Kendall M.D., Ladyman H., Nieuwenhuis P., Ritter M.A., Schuurman H-J., and Tournefier A. (1989). Thymic epithelial antibodies: Immunohistological analysis and introduction of nomenclature. Summary of the Epithelium Workshop held at the 2nd Workshop, "The Thymus. Histophysiology and Dynamics in the Immune System." Thymus 13: 165-173.
15. Kendall M.D. (1985). The outer and inner thymus cortex is a functional syncytium. Cell Biol. Int. Rep. 9: 3.
16. Kendall M.D. (1986). The syncytial nature of epithelial cells in the thymic cortex. J. Anat. 147: 95-106.
17. Kendall M.D., Al-Asam H., and Zaidi S.A.A. (Submitted). The morphology of large nerves in the rat thymus.
18. Kendall M.D., and Al-Shawaf A.A. (1991). Current knowledge on the innervation of the rat thymus gland. Brain Behav. Immun. 5: 9-28.
19. Kendall M.D., Atkinson B.A., Munoz F.J., Riva C. de la, and Clarke A.G. (1994). The noradrenergic innervation of the rat thymus during pregnancy and in the post partum period. J. Anat. 185: 617-625.
20. Krenacs T., and Rosendaal M. (1995). Immunohistological detection of gap-junctions in human lymphoid-tissue - connexin 43 in follicular dendritic and lymphoendothelial cells. J. Histochem. Cytochem. 43: 1125-1137.
21. Kumar N.M., and Gilula N.B. (1992). Molecular biology and genetics of gap junction channels. Sem. Cell Biol. 3: 3-16.
22. Kurz B., Gaudecker B. von, Kranz A., Krisch B., and Mentlein R. (1995). Calcitonin gene-related peptide and its receptor in the thymus. Peptides 16: 1497-1503.
23. Kurz B., Gaudecker B. von, Krisch G., and Mentlein R. (1996). Rat epithelial cells in vitro and in situ: Characterization by immunocytochemistry and morphology. Cell Tiss. Res. 283: 221-229.
24. Kurz B., Feindt J., Gaudecker B. von, Kranz A., Loppnow H., and Mentlein R. (1997). β-adrenoceptor-mediated effects in rat cultured thymic epithelial cells. Brit. J. Pharmacol. 120: 1401-1408.
25. Loewenstein W.R. (1979). Junctional intercellular communication and the control of growth. Biochim. Biophys. Acta 560: 1-65.
26. Meda P., Bosco D., Giordano E., and Chanson M. (1991). Junctional coupling modulation by secretagogues in two cell pancreatic systems. In Biophysics of Gap Junction Channels, Peracchia, C., Ed. (Boca Raton, FL: CRC Press), pp. 191-208.
27. Müller S., and Weihe E. (1991). Interrelation of peptidergic innervation with mast cells and ED-1 positive cells in the rat thymus. Brain Behav. Immun. 5: 55-72.
28. Munarisilem Y., Lebrethon M.C., Morand I., Roussel B., and Saez J.M. (1995). Gap junction-mediated cell-to-cell communication in bovine and human adrenal-cells: A process whereby cells increase their responsiveness to physiological corticotrophin concentrations. J. Clin. Invest. 95: 1429-1439.
29. Ngezhayo A., and Kolb H. (1993). Gap junctional conductance tunes phase difference of cholecystokinin evoked calcium oscillations in pairs of pancreatic acinar cells. Pflug. Arch. E. J. Physiol. 422: 413-415.
30. Pandol S.J. (1994). Pancreatic acinar cell signalling mechanisms. Curr. Op. Gasteroent. 10: 485-490.
31. Rosendaal M., Green C.R., Rahman A., and Morgan D. (1994). Up-regulation of the connexin-43(+) gap junction network in hematopoietic-tissue before the growth of stem cells. J. Cell Sci. 107: 29-37.
32. Santos-Sacchi J. (1991). Isolated supporting cells from the organ of Corti: Some whole cell electrical characteristics and estimates of gap junctional conductance. Hearing Res. 52: 89-98.
33. Takahashi K.I., and Copenhagen D.R. (1996). Modulation of neuronal function by intracellular pH. Neurosci. Res. 24: 109-116.
34. Trosko J.E., Madhukar B.V., and Chang C.C. (1993). Endogenous and exogenous modulation of gap Junctional intercellular communication: Toxicological and pharmacological implications. Life Sci. 53: 1-19.
35. Ueda F., Kameda Y., Yamamoto Y., and Shibata Y. (1994). Beta-adrenergic regulation of gap junctional intercellular communication in cultured rabbit gastric epithelial cells. J. Pharmacol. Exp. Therap. 271: 397-402.
36. Vizi E.S., Ordo E., Osipenko O.N., Hasko G., and Elenkov I.J. (1995). Neurochemical, electrophysiological and immunocytochemical evidence for a noradrenergic link between the sympathetic nervous system and thymocytes. Neurosci. 68: 1263-1276.
37. Weihe E., Müller S., Fink T., Zentel H.J. (1989). Tachykinins, calcitonin gene-related peptide and neuropeptide Y in nerves of the mammalian thymus: Interactions with mast cells in autonomic and sensory neuroimmunomodulation? Neurosci. Lett. 100: 77-82.
38. Wijngaert F.P. van de, Kendall M.D., Schuurman H.-J., Rademakers L.H.M.P., and Kater L. (1984). Heterogeneity of human thymus epithelial cells at the ultrastructural level. Cell. Tiss. Res. 237: 227-237.
39. Yeager M., and Nicholson B.J. (1996). Structure of gap junction intracellular channels. Curr. Op. Struct. Biol. 6: 183-192.