Possible rare involvement of O6-Methylguanine formation as a significant mutational factor in mouse urinary bladder carcinogenesis models

Teratogenesis Carcinogenesis and Mutagenesis

Volumn 18, Issue 3, 1998, Pages 101-110

  Chen, Tianxin ^a   Yamamoto, Shinji ^a   Kitano, Mitsuaki ^a   Murai, Takashi ^a,b   Wanibuchi, Hideki ^a   Matsukuma, Shoichi ^c   Nakatsuru, Yoko ^d   Ishikawa, Takatoshi ^d   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

^c KANAGAWA CANCER CENTER   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

BBN; MNU; Mouse urinary bladder carcinogenesis; O6 methylguanine DNA methyltransferase; p53 mutation

Indexed keywords

6 O METHYLGUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITROSOUREA; PROTEIN P53;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CARCINOGENESIS; BLADDER CARCINOMA; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DNA REPAIR; FEMALE; GENE MUTATION; MALE; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOSINE DEAMINASE; ANIMALS; BUTYLHYDROXYBUTYLNITROSAMINE; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CARCINOMA, TRANSITIONAL CELL; EPITHELIUM; FEMALE; GENES, P53; GUANINE; HUMANS; INCIDENCE; MALE; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; MUTATION; NEOPLASM INVASIVENESS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0031714856     PISSN: 02703211     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6866(1998)18:3<101::AID-TCM1>3.0.CO;2-K     Document Type: Article

References (23)

1. Strauss BS: The origin of point mutations in human tumor cells. Cancer Res 52:249-253, 1992.
2. Sato M, Nishigori C, Zghal M, Yagi T, Takebe H: Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients. Cancer Res 53:2944-2946, 1993.
3. Hollstein M, Sidransky D, Vogelstein B, Harris CC: p53 mutations in human cancers. Science (Washington, DC) 253:49-53, 1991.
4. Spruck CH III, Rideout WM III, Olumi AF, et al.: Distinct pattern of p53 mutations in bladder cancer: Relationship to tobacco usage. Cancer Res 53:1162-1166, 1993.
5. Fujimoto K, Yamada Y, Okajima E, Kakizoe T, Sasaki H, Sugimura T, Terada M: Frequent association of p53 gene mutation in invasive bladder cancer. Cancer Res 52:1393-1398, 1992.
6. 4-methyithymine in DNA. Carcinogenesis 16:1595-1602, 1995.
7. Masui T, Tetuka N. Nakanishi H, Inada K, Miyashita N, Tatematsu M: Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of H-ras and p53 genes. Cancer Lett 111 :97-104, 1997.
8. 6-methylguanine. Nature 308:201-203, 1984.
9. 6-methylguanine-DNA methyltransferase activity in transgenic mice containing an integrated E. coli ada repair gene. Mutat Res 218:197-206, 1989.
10. 6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis. Proc Natl Acad Sci USA 90:6468-6472, 1993.
11. Zaidi NH, Pretlow TP, O'Riordan MA, Dumenco LL, Allay E, Gerson SL: Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis 16:451-456, 1995.
12. Tamano S, Shirai T, Kawabe M, Ni-I H, Mori Y, Okada M, Fukushima S: Low susceptibility of nude mice to induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)-nitrosamine. Toxicol Pathol 20:205-211, 1992.
13. Tamano S, Hagiwara A, Suzuki E, Okada M, Shirai T, Fukushima S: Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)-nitrosamine in B6C3F1 mice. Jpn J Cancer Res 82:650-656, 1991.
14. Masui T, Dong Y, Yamamoto S, Takada N, Nakanishi H, Inada K-I, Fukushima S, Tatematsu M: p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine. Cancer Lett 105:105-112, 1996.
15. Masui T, Don I, Takada N, Ogawa K, Shirai T, Fukushima S: p53 mutations in early neoplastic lesions of the urinary bladder in rat treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine. Carcinogenesis 15:2379-2381, 1994.
16. Yamamoto S, Masui T, Murai T, Mori S, Oohara T, Makino S, Fukushima S, Tatematsu M: Frequent mutations of p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis 16:2363-2368, 1995.
17. Yamamoto S, Chen TX, Murai T, Mori S, Morimura K, Oohora T, Makino S, Tatematsu M, Wanibuchi H, Fukushima S: Genetic instability and p53 mutations in metastatic foci of mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis 18:1877-1882, 1997.
18. Lee CCR, Yamamoto S, Morimura K, Wanibuchi H, Nishisaka N, Ikemoto S, Nakatani T, Wada S, Kishimoto T, Fukushima S: Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features. Cancer 79:780-789, 1997.
19. Greenblatt MS, Bennett WP, Hollstein M, Harris CC: Mutations in the p53 tumor suppression gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878, 1994.
20. 6-alkylguanine-DNA alkyltransferase. Science 259:219-222, 1993.
21. Yamamoto S, Tatematsu M, Yamamoto M, Fukami H, Fukushima S: Clonal analysis of urothelial carcinomas in C3H/HeN BALB/c chimeric mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis 19:855-860, 1998.
22. Kantor AF, Hartge P, Hoover RN, Narayana AS, Sullivan JW, Fraumeni JF Jr: Urinary tract infection and risk of bladder cancer. Am J Epidemiol 119:510-515, 1984.
23. Chen TX, Yamamoto S, Gen H, Murai T, Mori S, Oohara T, Makino S, Wanibuchi H, Fukushima S: Infrequent involvement of microsatellite instability in urinary bladder carcinomas of the NON/ Shi mouse treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett 123:41-45, 1998.