Expression of cadherin-catenin cell adhesion molecules, phosphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers

Japanese Journal of Cancer Research

Volumn 89, Issue 8, 1998, Pages 829-836

  Akimoto, Shingo ^a   Ochiai, Atsushi ^a   Inomata, Masafumi ^a   Hirohashi, Setsuo ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Cadherin mediated cell adhesion; Tyrosine phosphorylation; Undifferentiated gastric cancer; catenin

Indexed keywords

ALPHA CATENIN; BETA CATENIN; CADHERIN; CATENIN; CELL ADHESION MOLECULE; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; ONCOPROTEIN; PHOSPHOTYROSINE; TYROSINE KINASE RECEPTOR; UVOMORULIN;

ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONCOGENE C ERB; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; STOMACH ADENOCARCINOMA; STOMACH CANCER;

EID: 0031714759     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1998.tb00636.x     Document Type: Article

References (33)

1. Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science, 251, 1451-1455 (1991).
2. Nagafuchi, A. and Takeichi, M. Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J., 7, 3679-3684 (1988).
3. Ozawa, M.. Baribault, H. and Kemler, R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J., 8, 171 1-1717 (1989).
4. Behrens, J., Mareel, M. M., Van Roy, F. M. and Birchmeier, W. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J. Cell Biol., 108, 2435-2447 (1989).
5. Frixen, U. H., Behrens, J., Sachs. M., Eberle, G., Voss, B., Warda, A., Lochner, D. and Birchmeier, W. E-Cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol., 113, 173-185 (1991).
6. Vleminckx, K., Vakaet, L., Jr., Mareel, M., Fiers, W. and van Roy, F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell, 66, 107-119 (1991).
7. Oda, T., Kanai, Y., Oyama, T., Yoshiura, K., Shimoyama, Y., Birchmeier, W., Sugimura, T. and Hirohashi, S. E-Cadherin gene mutations in human gastric carcinoma cell lines. Proc. Natl. Acad. Sci. USA, 91, 1858-1862 (1994).
8. Oyama, T., Kanai, Y., Ochiai, A., Akimoto, S., Oda, T., Yanagihara, K., Nagafuchi, A., Tsukita, S., Shibamoto, S., Ito, F., Takeichi, M., Matsuda, H. and Hirohashi, S. A truncated β-catenin disrupts the interaction between E-cadherin and α-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res., 54, 6282-6287 (1994).
9. Yoshiura, K., Kanai, Y., Ochiai, A., Shimoyama, Y., Sugimura, T. and Hirohashi, S. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. USA, 92, 7416-7419 (1995).
10. Kanai, Y., Ushijima, S., Hui, A. M., Ochiai, A., Sakamoto, M. and Hirohashi, S. The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas. Int. J. Cancer, 71, 355-359 (1997).
11. Matsuyoshi, N., Hamaguchi, M., Taniguchi, S., Nagafuchi, A., Tsukita, S. and Takeichi, M. Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts. J. Cell Biol., 118, 703-714 (1992).
12. Shibamoto, S., Hayakawa, M., Takeuchi, K., Hori, T., Oku, N., Miyazawa, K., Kitamura, N., Takeichi, M. and Ito, F. Tyrosine phosphorylation of β-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhes. Commun., 1, 295-305 (1994).
13. Ochiai, A., Akimoto, S., Kanai, Y., Shibata, T., Oyama, T. and Hirohashi, S. c-erbB-2 gene product associates with catenins in human cancer cells. Biochem. Biophys. Res. Commun., 205, 73-78 (1994).
14. Hoschuetzky, H., Aberle, H. and Kemler, R. β-Catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J. Cell Biol., 127, 1375-1380 (1994).
15. Kanai, Y., Ochiai, A., Shibata, T., Oyama, T., Ushijima, S., Akimoto, S. and Hirohashi, S. c-erbB-2 gene product directly associates with β-catenin and plakoglobin. Biochem. Biophys. Res. Commun., 208, 1067-1072 (1995).
16. Becker, K.-F. and Hoeler, H. Frequent somatic allelic inactivation of the E-cadherin gene in gastric carcinomas. J. Natl. Cancer Inst., 87, 1082-1084 (1995).
17. Muta, H., Noguchi, M., Kanai, Y., Ochiai, A., Nawata, H. and Hirohashi, S. E-Cadherin gene mutation in signet ring cell carcinoma of the stomach. Jpn. J. Cancer Res., 87, 843-848 (1996).
18. Shimoyama, Y., Hirohashi, S., Hirano, S., Noguchi, M., Shimosato, Y., Takeichi, M. and Abe, O. Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res., 49, 2128-2133 (1989).
19. Hattori, Y., Itoh, H., Uchino, S., Hosokawa, K., Ochiai, A., Ino, Y., Ishii, H., Sakamoto, H., Yamaguchi, N., Yanagihara, K., Hirohashi, S., Sugimura, T. and Terada, M. Immunohistochemical detection of k-sam protein in stomach cancer. Clin. Cancer Res., 2, 1373-1381 (1996).
20. Shimoyama, Y. and Hirohashi, S. Expression of E-and P-cadherin in gastric carcinomas. Cancer Res., 51, 2185-2192 (1991).
21. Ochiai, A., Akimoto, S., Shimoyama, Y., Nagafuchi, A., Tsukita, S. and Hirohashi, S. Frequent loss of α catenin expression in scirrhous carcinomas with scattered cell growth. Jpn. J. Cancer Res., 85, 266-273 (1994).
22. Shiozaki, H., Tahara, H., Oka, H., Miyata, M., Kobayashi, K., Tamura, S., Iihara, K., Doki, Y., Hirano, S., Takeichi, M. and Mori, T. Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am. J. Pathol., 139, 17-23 (1991).
23. Shiozaki, H., Iihara, K., Oka, H., Kadowaki, T., Matsui, S., Gofuku, J., Inoue, M., Nagafuchi, A., Tsukita, S. and Mori, T. Immunohistochemical detection of α-catenin expression in human cancers. Am. J. Pathol., 144, 667-674 (1994).
24. Takayama, T., Shiozaki, H., Shibamoto, S., Oka, H., Kimura, Y., Tamura, S., Inoue, M., Monden, T., Ito, F. and Monden, M. β-Catenin expression in human cancers. Am. J. Pathol., 148, 39-46 (1996).
25. Nakatani, H., Tahara, E., Yoshida, T., Sakamoto, H., Suzuki, T., Watanabe, H., Sekiguchi, M., Kaneko, Y., Sakurai, M., Terada, M. and Sugimura, T. Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel. Jpn. J. Cancer Res., 77, 849-853 (1986).
26. Miki, T., Fleming, T. P., Bottaro, D. P., Rubin, J. S., Ron, D. and Aaronson, S. A. Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science, 251, 72-75 (1991).
27. Munemitsu, S., Albert, I., Souza, B., Rubinfeld, B. and Polakis, P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA, 92, 3046-3050 (1995).
28. Nakatsuru, S., Yanagisawa, A., Ichii, S., Tahara, E., Kato, Y., Nakamura, Y. and Horii, A. Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. Hum. Mol. Genet., 1, 559-563 (1992).
29. Inomata, M., Ochiai, A., Akimoto, S., Kitano, S. and Hirohashi, S. Alteration of β-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients. Cancer Res., 56, 2213-2217 (1996).
30. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B. and Kinzler, K. W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science, 275, 1787-1790 (1997).
31. Rubinfeld, B., Robbins, P., El-Gamil, M., Albert, I., Porfiri, E. and Polakis, P. Stabilization of β-catenin by genetic defects in melanoma cell lines [see comments]. Science, 275, 1790-1792 (1997).
32. Behrens, J., von Kries, J. P., Kuhl, M., Bruhn, L., Wedlich, D., Grosschedl, R. and Birchmeier, W. Functional interaction of β-catenin with the transcription factor LEF-1. Nature, 382, 638-642 (1996).
33. Nishi, M. "Japanese Classification of Gastric Carcinoma," pp. 38-51 (1995). Kanehara & Co., Ltd., Tokyo.