Apoptosis and Bcl-2 oncoprotein expression in the human fetal central nervous system

Anatomical Record

Volumn 252, Issue 2, 1998, Pages 165-175

  Chan, W Y ^a   Yew, D T ^a  

^a Prince of Wales Hospital   (Hong Kong)

Author keywords

Apoptosis; Bcl 2 oncoprotein; Brainstem nuclei; Cerebral cortex; Hippocampus; Human development; Immunocytochemical staining; TUNEL

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; MONOCLONAL ANTIBODY; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; FETUS; FETUS DEVELOPMENT; GESTATIONAL AGE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LOCUS CERULEUS; NERVOUS SYSTEM DEVELOPMENT; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIBODIES, MONOCLONAL; APOPTOSIS; BRAIN; BRAIN STEM; CELL COUNT; CEREBRAL CORTEX; FEMALE; FETUS; GESTATIONAL AGE; HIPPOCAMPUS; HUMANS; IN SITU NICK-END LABELING; PREGNANCY; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0031711869     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0185(199810)252:2<165::AID-AR2>3.0.CO;2-2     Document Type: Article

References (46)

1. Allsopp TE, Wyatt S, Paterson HF, Davies AM. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 1993;73:295-307.
2. H on chromosome 14 and near a transcriptional unit on chromosome 18. Cell 1985;41:899-906.
3. Boise LH, Gonzalez-Barcia M, Postem CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993;74:597-608.
4. Bursch W, Paffe S, Putz B, Barthel G, Schulte-Hermann R. Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carcinogenesis 1990;11:847-853.
5. Chang GQ, Hao Y, Wong F. Apoptosis: Final common pathway of photoreceptor death in rd,rds and rhodopsin mutant mice. Neuron 1993;11:595-605.
6. Chen DF, Schneider GE, Martinou J-C, Tonegawa S. Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature 1997;385: 434-439.
7. Cleary ML, Sklar J. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc. Natl. Acad. Sci. USA 1985;82:7439-7443.
8. Cohen JJ. Programmed cell death in the immune system. Adv. Immunol. 1991;50:55-85.
9. Cowan WM, Fawcett JW, O'Leary DD, Stanfield BB. Progressive events in neurogenesis. Science 1984;225:1258-1265.
10. Cuende E, Ales-Martinez JE, Gonzales-Garcia M, Martinez A-C, Nunez G. Programmed cell death by bcl-2 dependent and independent mechanisms in B lymphoma cells. EMBO J. 1993;12:1555-1560.
11. Ellis HM, Yuan J, Horvitz HR. Mechanisms and functions of cell death. Annu. Rev. Cell Biol. 1991;7:663-698.
12. Ferrer I, Bernet E, Soriano E, Del Rio T, Fonseca M. Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes. Neuroscience 1990a;39:451-458.
13. Ferrer I, Serrano T, Soriano E. Naturally occurring cell death in the subicular complex and hippocampus in the rat during development. Neurosci. Res. 1990b;8:60-66.
14. Ferrer I, Tortosa A, Blanco R, Martin F, Serrano T, Planas A, Macaya A. Naturally occurring cell death in the developing cerebral cortex of the rat. Evidence of apoptosis associated internucleosomal DNA fragmentation. Neurosci. Lett. 1994;182:77-79.
15. Fesus L, Davies PJA, Piacentini M. Apoptosis: Molecular mechanisms in programmed cell death. Eur. J. Cell Biol. 1991;56:170-177.
16. Garcia I, Martinou I, Tsuujimoto Y, Martinou JC. Prevention of programmed cell death of sympathetic neurons by the bcl-2 protooncogene. Science 1992;258:302-304.
17. Gold R, Schmied M, Giegerich G, Breitschopf H, Hartung HP, Tokyka KV, Lassmann H. Differentiation between cellular apoptosis and necrosis by combined use of in situ tailing and nick translation techniques. Lab. Invest. 1994;71:219-225.
18. Gould E, Wooley CS, McEwen BS. Naturally occurring cell death in the developing dentate gyrus of the rat. J. Comp. Neurol. 1991;304: 408-418.
19. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;248:334-336.
20. Jacobson MD, Burne JF, King MP, Miyashita T, Reed JC, Raff MC. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 1993;361:365-369.
21. Kerr JFT, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide ranging implication in tissue kinetics. Br. J. Cancer 1972;26:239-257.
22. Korsmeyer SJ. Bcl-2: An antidote to programmed cell death. Cancer Surveys 1992;15:105-118.
23. Kostovic L, Rakic P. Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain. J. Comp. Neurol. 1990;297:441-470.
24. Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC. Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 1993;53:4701-4714.
25. Krajewski S, Mai JK, Krajewska M, Sikorska M, Mossakowski MJ, Reed JC. Upregulation of Bax protein levels in neurons following cerebral ischemia. J. Neurosci. 1995;15:6364-6376.
26. LeBrun DP, Warnke RA, Cleary ML. Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am. J. Path. 1993;142:743-753.
27. Levi-Montalcini R. The nerve growth factor: Thirty-five years later. EMBO J. 1987;6:1145-1154.
28. Mah SP, Zhong LT, Liu Y, Roghani A, Edwards RH, Bredesen DE. The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J. Neurochem. 1993;60:1183-1186.
29. Merry DE, Veis DJ, Hickey WF, Korsmeyer SJ. bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 1994;120:301-311.
30. Monaghan P, Robertsen D, Amos TAS, Dyer MJS, Mason DY, Greaves MF. Ultrastructural localization of Bcl-2 protein. J. Histochem. Cytochem. 1992;40:1819-1825.
31. Novak VD, Korsmeyer SJ. bcl-2 protein expression during murine development. Am. J. Path. 1994;145:61-73.
32. Oltvai Z, Milliman C, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609-619.
33. Oppenheim RW. Cell death during development of the nervous system. Ann. Rev. Neurosci. 1991;14:453-501.
34. Papermaster DS, Windle J. Death at the early age: Apoptosis in inherited retinal degeneration. Invest. Ophthalmol. Vis. Sci. 1995;36: 977-983.
35. Prindull G. Apoptosis in the embryo and tumorigenesis. Eur. J. Cancer 1995;31:116-123.
36. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD. Programmed cell death and control of cell survival: Lessons from the nervous system. Science 1993;262:695-700.
37. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 1991;67:879-888.
38. Shatz CJ, Chun JJ, Luskin MB. The role of subplate in the development of the mammalian telencephalon. In: Peters A, Jones EG, eds. Cerebral Cortex. Vol. 7. New York: Plenum, 1988;35-38.
39. Sinicrope FA, Ruan SR, Cleary KR, Stephens LC, Lee JJ, Levin B. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res. 1995;55:237-241.
40. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985;228:1440-1443.
41. Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988;335:440-442.
42. Vekrellis K, McCarthy MJ, Watson A, Whitfield J, Rubin LL, Ham J. Bax promotes neuronal cell death and is downregulated during the development of the nervous system. Development 1997;124:1239-1249.
43. White E. Life, death and the pursuit of apoptosis. Genes Dev 1996;10: 1-15.
44. Woo TU, Beale J, Finlay B. Dual fate of subplate neurons in a rodent. Cerebral Cortex 1991;1:433-443.
45. Wyllie AH, Kerr JFR, Currie AR. Cell death: The significance of apoptosis. Int. Rev. Cytol. 1980;68:251-306.
46. Wyllie AH, Morris RG, Smith AL, Dunlop D. Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Path. 1984;142:67-77.