The relevance of photomutagenicity testing as a predictor of photocarcinogenicity

International Journal of Toxicology

Volumn 17, Issue 5, 1998, Pages 551-558

  Müller, Lutz ^a   Kasper, Peter ^a  

^a Federal Institute for Drugs and Medical Devices   (Germany)

Author keywords

Fluoroquinolones; Photocarcinogenic testing; Photomutagenicity; UV

Indexed keywords

DNA BASE; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

CARCINOGENICITY; CHROMOSOME DAMAGE; CONFERENCE PAPER; DIMERIZATION; GENE MUTATION; GENOTOXICITY; MAMMAL CELL; MUTAGENICITY; PHOTOSYNTHESIS; PREDICTION; SKIN TUMOR; ULTRAVIOLET RADIATION;

EID: 0031708073     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/109158198226053     Document Type: Conference Paper

References (17)

1. Chételat, A. A., S. Albertini, J. H. Dresp, R. Strobel, and E. Gocke. 1993a. Photomutagenesis test development: I. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in bacterial and yeast assays. Mutat. Res. 292:241-250.
2. Chételat, A. A., S. Albertini, and E. Gocke. 1996. The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay). Mutagenesis 11:497-504.
3. Chételat, A. A., J, H. Dresp, and E. Gocke. 1993b. Photomutagenesis test development: II. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in chromosomal aberration assays using CHO cells. Mutat. Res. 292: 251-258.
4. Combes, R. D. 1995. Mutagenicity testing of cosmetics: Current trends and prospects for the replacement, refinement, and reduction of animal testing. Comments Toxicol. 5:247-270.
5. Dean, S. W., M. Lane, R. H. Dunmore, S. P. Ruddock, C. N. Martin, D. J. Kirkland, and N. Loprieno. 1991. Development of assays for the detection of photomutagenicity of chemicals during exposure to UV-light: I. Assay development. Mutagenesis 6:335-341.
6. De Vries, A., C. Th. M. Van Oostrom, F. M. A. Hofhuis, P. M. Dortant, R. J. W. Berg, F. R. De Gruijl, P. W. Wester, C. F. Van Kreijl, P. J. A. Chapel, H. Van Steeg, and S. Verbeek. 1995. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 377:169-173.
7. Emerit, I. 1994. Reactive oxygen species, chromosome mutation, and cancer: Possible role of clastogenic factors in carcinogenesis. Free Radic. Biol. Med. 16:99-109.
8. Gorelick, N. J. 1995. UVA- and UVB-induced mutational spectra in the lad gene from transgenic mouse skin. Abstract, Photocarcinogenesis; Mechanisms, Models and Human Health Implications, Washington, Oct. 27-28, 1995.
9. Henderson, L., J. Fedyk, C. Bourner, S. Windebank, S. Fletcher, and W. Lovell. 1994. Photomutagenicity assays in bacteria: Factors affecting assay design and assessment of photomutagenic potential of para-aminobenzoic acid. Mutagenesis 9:459-465.
10. Klecak, G., F. Urbach, and H. Urwyler. 1997. Fluoroquinolone antibaeterials enhance UVA-induced skin tumors. J. Photochem. Photobiol. B: Biology 37: 174-181.
11. Loprieno, N. 1991. In vitro assay systems for testing photomutagenic chemicals. Mutagenesis 6:331-333.
12. Loveday, K. S. 1996. Interrelationship of photocarcinogenicity, photomutagenicity and phototoxicity. J. Photochem. Photobiol. 63:369-372.
13. Robertson, D. G., G. A. Epling, J. S. Kiely, D. L. Bailey, and B. Song. 1991. Mechanistic studies on the phototoxic potential of PD 117596, a quinolone antibacterial compound. Toxicol. Appl. Pharmacol. 111:221-232.
14. Stern, R. S., and N. Laird. 1994. The carcinogenic risk of treatment for severe psoriasis. Cancer 73:2759-2764.
15. Stern, R. S., K. T. Nichols, and L. H. Väkevä. 1997. Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). New Engl. J. Med. 336:1041-1045.
16. Wagai, N., and K. Tawara. 1992. Possible direct role of reactive oxygen species in the cause of cutaneous phototoxicity induced by five quinolones in mice. Arch. Toxicol. 66:392-397.
17. Youssefi, A. A., R. Arutyunyan, and I. Emerit. 1994. Chromosome damage in PUVA-treated human lymphocytes is related to active oxygen species and clastogenic factors. Mutat. Res. 309:185-191.