Anethole trithione raises levels of α-calcitonin gene-related peptide in saliva of healthy subjects

Pharmacy and Pharmacology Communications

Volumn 4, Issue 9, 1998, Pages 459-463

  Nagano, Toshiaki ^a   Ikawa, Kazuro ^a   Takeyama, Masaharu ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CALCITONIN GENE RELATED PEPTIDE; ANETHOLE TRITHIONE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; SALIVA LEVEL; SALIVATION;

EID: 0031706002     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Amara, S. G., Jonas, V., Rosenfeld, M. G., Ong, E. S., Evans, R. M. (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298: 240-244
2. Amara, S. G., Arriza, J. L., Leff, S. E., Swanson, L. W., Evans, R. M., Rosenfeld, G. (1985) Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide. Science 229: 1094-1097
3. Dawidson, I., Blom, M., Lundberg, T., Theodorsson. E., Angmar-Månsson, B. (1997) Neuropeptides in the saliva of healthy subjects. Life Sci. 60: 269-278
4. Domoto, T., Yang, H., Bishop, A. E., Polk, J. M., Oki, M. (1993) Distribution and origin of extrinsic nerve fibers containing calcitonin gene-related peptide, substance P, and galanin in the rat upper rectum. Neurosci. Res. 15: 64-73
5. Ekström, J. (1987) Neuropeptides and secretion. J. Dent. Res. 66: 524-530
6. Ekström, J., Ekman, R., Håkanson, R., Sjögren, S., Sundler, F. (1988) Calcitonin gene-related peptide in rat salivary glands: neuronal localization, depletion upon nerve stimulation, and effects on salivation in relation to substance P. Neuroscience 26: 933-949
7. Epstein, J. B., Decoteau, W. E., Wilkinson, A. (1983) Effect of sialor in treatment of xerostomia in Sjögren's syndrome. Oral Surg. 56: 495-499
8. Green, T., Dockray, G. J. (1988) Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea-pig. Neuroscience 25: 181-193
9. Hayashi, T., Okuyama, Y., Komura, H., Morino, A., Sugiyama, M., Nomura, A. (1990) Studies on the metabolic fate of anethole trithione (1). Iyakuhin Kenkyu 21: 584-602
10. Ju, G., Hökfelt, T., Brodin, E., Fahrenkrug, J., Fischer, J. A., Frey, P., Elde, R. P., Brown, J. C. (1987) Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, soma-tostatin-, galanin-, vasoactive intestinal peptide- and cholecystokinin-immunoreactive ganglion cells. Cell Tissue Res. 247: 417-431
11. Kusakabe, T., Matsuda, H., Kawakami, T., Syoui, N., Kurihara, K., Tsukuda, M., Takenaka, T. (1997) Distribution of neuropeptide-containing nerve fibers in the human submandibular gland, with special reference to the difference between serous and mucous acini. Cell Tissue Res. 288: 25-31
12. Lelord, G., Mercat, C., Fuseiller, C. (1969) Intérêt dutrithioparaméthoxy-phénylpropène (Sulfarlem) dans la prévention des complications salivaries des traitements psychotropes. Gaz. Med. Fr. 76: 2257-2262
13. Morley, J. E., Farr, S. A., Flood, J. F. (1996) Peripherally administered calcitonin gene-related peptide decreases food intake in mice. Peptides 17: 511-516
14. Morris, H. R., Panico, M., Etienne, T., Tippins, J., Girgis, S. I., MacIntyre, I. (1984) Isolation and characterization of human calcitonin gene-related peptide. Nature 308: 746-748
15. Navazesh, M., Christensen, C. H. (1982) A comparison of whole mouth resting and stimulated salivary measurement procedure. J. Dent. Res. 61: 1158-1162
16. Kohler, P. E., Winter, M. E. (1985) A quantitative test for xerostomia. Art. Rheum. 28: 1128-1132
17. Petermann, J. B., Born, W., Chang, J. Y., Fischer, J. A. (1987) Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord. J. Biol. Chem. 262: 542-545
18. Rosenfeld, M. G., Mermod, J. -J., Amara, S. G., Swanson, L. W., Swachenko, P. E., River, J., Vale, W. W., Evans, R. M. (1983) Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304: 129-135
19. Streenbergh, P. H., Höppener, J. W. M., Zandberg, J., Lips, C. J. M., Jansz, H. S. (1985) A second human calcitonin/CGRP gene. FEBS Lett. 183: 403-407
20. Streenbergh, P. H., Höppener, J. W. M., Zandberg, J., Visser, A., Lips, C. J. M., Jansz, H. S. (1986) Structure and expression of the human calcitonin/CGRP gene. FEBS Lett. 209: 97-103
21. Takeyama, M., Nagano, T., Ikawa, K. (1996) Anethole trithione raises levels of substance P in human saliva. Pharm. Sci. 2: 581-584