Peripherally administered calcitonin gene-related peptide decreases food intake in mice

Peptides

Volumn 17, Issue 3, 1996, Pages 511-516

  Morley, John E ^b   Farr, Susan A ^b   Flood, James F ^a  

^a Medical Research Service (151/JC)   (United States)

^b NONE

Author keywords

Amylin; Anorexia; Appetite; Calcitonin gene related peptide; Cholecystokinin; Food intake; Mice Motivation; Taste aversion

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CHOLECYSTOKININ A RECEPTOR ANTAGONIST; CHOLECYSTOKININ RECEPTOR; DEVAZEPIDE; LITHIUM CHLORIDE; SACCHARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVERSION; CONTROLLED STUDY; DOSE RESPONSE; FLUID INTAKE; FOOD DEPRIVATION; FOOD INTAKE; GENETIC MODEL; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REINFORCEMENT; SATIETY; TASTE; WATER DEPRIVATION;

ANIMALIA;

EID: 0029953170     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/0196-9781(96)00015-0     Document Type: Article

References (39)

1. Batt, R. A. Decreased food intake in response to cholecystokinin (pancreozymin) in wild-type and obese mice (genotype ob/ob). Int. J. Obes. 7:25-29; 1983.
2. Bailey, C. J.; Flatt, P. R. Anorectic effect of fenfluramine, cholecystokinin and neurotensin in genetically obese (ob/ob) mice. Comp. Biochem. Physiol. [A] 84:451-454; 1986.
3. Bellinger, L. L.; Mendel, V. E. The effect of intracerebroventricularly infused satietin on conditioned taste aversion and feeding in rats fasted different lengths. Pharmacol. Biochem. Behav. 23:559-566; 1985.
4. Billington, C. J.; Levine, A. S.; Morley, J. E. Are peptides truly satiety agents? A method of testing for neurohumoral satiety effects. Am. J. Physiol. 245:R920-R929; 1983.
5. Campfield, L. A.; Smith, F. J.; Guisez, Y.; Devos, R.; Burn, P. Recombinant mouse ob protein: Evidence for a peripheral signal linking adeposity and central networks. Science 269:546-549; 1995.
6. Chance, W. T.; Balasurbamaniam, A.; Stallion, A.; Fischer, J. E. Anorexia following the systemic injection of amylin. Brain Res. 607:1185-1188; 1993.
7. Chang, R. S. L.; Lotti, V. J. Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist. Proc. Natl. Acad. Sci. USA 83:4923-4926; 1986.
8. Coleman, D. L. Obese and diabetes: Two mutant genes causing diabetes-obesity sndromes in mice. Diabetologia 14:141-148; 1978.
9. Edwards, B. J.; Morley, J. E. Amylin. Life Sci. 51:1899-1912; 1992.
10. Edwards, B. J.; Perry, H. M.; Kaiser, F. E.; et al. Postprandial hypotension: a role for CGRP. Clin. Res. 40:434a; 1992.
11. Flood, J. F.; Silver, A. J.; Morley, J. E. Do peptide-induced changes in feeding occur because of changes in motivation to eat? Peptides 11:265-270; 1990.
12. Garcia, J.; Kimeldorf, D. J.; Hunt, E. L. The use of ionizing radiation as a motivating stimulus. Psychol. Rev. 68:383-395; 1961.
13. Gibbs, J.; Kulkosky, P. J.; Smith, G. P. Effects of peripheral and central bombesin on feeding behavior of rats. Peptides 2(Suppl. 2):179-183; 1981.
14. Halaas, J. L.; Gajiwala, K. S.; Maffei, M.; et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546; 1995.
15. Hartter, E.; Svoboda, T.; Ludvik, B.; et al. Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans. Diabetologia 34:52-54; 1991.
16. Hewson, G.; Leighton, G. E.; Hill, R. G.; Hughes, J. The cholecystokinin receptor antagonist L364,718 increases food intake in the rat by attenuating the effects of endogenous cholecystokinin. Br. J. Pharmacol. 93:74-82; 1988.
17. Krahn, D. D.; Gosnell, B. A.; Levine, A. S.; Morley, J. E. Effects of calcitonin gene-related peptide on food intake. Peptides 5:861-864; 1984.
18. Krahn, D. D.; Gosnell, B. A.; Levine, A. S.; Morley, J. E. Effects of calcitonin gene-related peptide on food intake involves aversive mechanisms. Pharmacol. Biochem. Behav. 24:5-7; 1986.
19. Leibowitz, S. F. Neurochemical-neuroendocrine systems in the brain controlling macronutrient intake and metabolism. Trends Neurosci. 15:491-497; 1992.
20. Levine, A. S.; Morley, J. E. Peripherally administered somatostatin reduces feeding by a vagal mediated mechanism. Pharmacol. Biochem. Behav. 16:897-902; 1982.
21. Lutz, T. A.; Del Prete, E.; Scharrer, E. Reduction of food intake in rats by intraperitoneal injection of low dose amylin. Physiol. Behav. 55:891-895; 1994.
22. Morley, J. E. The neuroendocrine control of appetite: The role of the endogenous opiates, cholecystokinin, TRH, gamma-amino butyric acid and the diazepan receptor. Life Sci. 27:355-368; 1980.
23. Morley, J. E. Neuropeptide regulation of appetite and weight. Endocr. Rev. 8:256-287; 1987.
24. Morley, J. E.; Flood, J. F. The effect of amylin on food intake in normal and diabetic mice. Peptides 12:865-870; 1991.
25. Morley, J. E.; Levine, A. S.; Kneip, J.; Grace, M.; Billington, C. J. The effect of peripherally administered satiety substances on feeding induced by butorphanol tartrate. Pharmacol. Biochem. Behav. 19:577-582; 1983.
26. Morley, J. E.; Morley, P. M. K.; Flood, J. F. Anorectic effects of amylin in rats over the life span. Pharmacol. Biochem. Behav. 44:577-580; 1993.
27. Morley, J. E.; Flood, J. F.; Horowitz, M.; Morley, P. M. K.; Walter, M.J. Modulation of food intake by peripherally administered amylin. Am. J. Physiol. 267:R178-184; 1994.
28. Nachman, M.; Ashe, J. H. Learned taste aversion in rats as a function of dosage, concentration and route of administration of LiCl. Physiol. Behav. 10:73-78; 1973.
29. Shide, D. J.; Caballero, B.; Reidelberger, R.; Rolls, B. J. Accurate energy compensation for intragastric and oral nutrients in lean males. Am. J. Clin. Nutr. 61:754-764; 1995.
30. Silver, A. J.; Flood, J. F.; Song, A. M.; Morley, J. E. Evidence for a physiological role of CCK in the regulation of food intake in mice. Am. J. Physiol. 256:R646-R652; 1989.
31. Silver, A. J.; Morley, J. E. The role of CCK in regulation of food intake. Prog. Neurobiol. 36:23-24; 1991.
32. Smith, G. P.; Gibbs, J. Satiating effect of cholecystokinin. Ann. NY Acad. Sci. 713:236-241; 1994.
33. Tannenbaum, G. S.; Gotzman, D. Calcitonin gene-related peptide mimics calcitonin actions in brain on growth hormone release and feeding. Endocrinology 116:2685-2687; 1985.
34. Trasforini, G.; Margutti, A.; Portaluppi, F.; et al. Circadian profile of plasma calcitonin gene-related peptide in healthy men. J. Clin. Endocrinnol. Metab. 73:945-951; 1991.
35. VanderWeele, D. A. Insulin is a prandial satiety hormone. Physiol Behav. 56:619-622; 1994.
36. Weigle, D. S. Appetite and the regulation of body composition. FASEB J. 8:302-310; 1994.
37. Wimalawansa, S. J. Effects of in vivo stimulation on molecular forms of circulatory calcitonin and calcitonin gene related peptide in man. Mol. Cell. Endocrinol. 71:13-19; 1990.
38. Zelissen, P. M. J.; Koppeschaar, H. P. F.; Lips, C. J. M.; Hackeng, W. H. L. Calcitonin gene-related peptide in human obesity. Peptides 12:861-863; 1991.
39. Zhang, Y.; Proenca, R.; Mafei, M.; Barone, M.; Leopold, L.; Friedman, J. M. Positional cloning of the mouse obese gene and its human homolgue. Nature 372:425-432; 1994.