Tibolone prevents atherosclerotic lesion formation in cholesterol-fed, ovariectomized rabbits

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 12, 1998, Pages 1844-1854

  Zandberg, Pieter ^a   Peters, Jan L M ^a   Demacker, Pierre N M ^b   Smit, Martin J ^a   De Reeder, Ernst G ^a   Meuleman, Dirk G ^a  

^a NV ORGANON   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Aorta; Atherogenesis; Lipids; Org OD14; Sex hormones

Indexed keywords

SEX HORMONE; TIBOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROGENIC DIET; ATHEROSCLEROSIS; BLOOD VESSEL REACTIVITY; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG EFFECT; EXTRACELLULAR MATRIX; HORMONE SUBSTITUTION; LIPID BLOOD LEVEL; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE RELAXATION;

EID: 0031702541     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.12.1844     Document Type: Article

References (16)

1. Barrett-Connor E, Bush TL. Estrogen and coronary heart disease in women. JAMA. 1991;265:1861-1867.
2. Barrett-Connor E. The menopause, hormone replacement, and cardiovascular disease: the epidemiologic evidence. Maturitas. 1996;23:227-234.
3. Kafonek SD. Post menopausal hormone replacement therapy and cardiovascular risk reduction. Drugs. 1994;47(suppl 2):16-24.
4. Seed M. Postmenopausal hormone replacement therapy, coronary heart disease and plasma proteins. Drugs. 1994;47(suppl 2):25-34.
5. Godsland IF, Wynn V, Crook D, Miller NE. Sex, plasma lipoproteins and atherosclerosis: prevailing assumptions and outstanding questions. Am Heart J. 1987;114:1467-1503.
6. Newham HM. Oestrogens and atherosclerotic vascular disease-lipid factors. Baillieres Clin Endocrinol Metab. 1993;7:61-93.
7. Adams MR, Williams JK, Clarkson TB, Jayo MJ. Effects of oestrogens and progestogens on coronary atherosclerosis and osteoporosis of monkeys. Baillieres Clin Endocrinol Metab. 1991;5(chapter 10): 915-934.
8. Clarkson TB, Anthony MS, Klein KP. Effects of estrogen on arterial wall structure and function. Drugs. 1994;47(suppl 2):42-51.
9. Davies MJ, Woolf N. Atherosclerosis: what is it and why does it occur? Br Heart J. 1993;69(suppl):S3-S11.
10. Gangar KF, Reid BA, Crook D, Hillard TC, Whitehead MI. Oestrogens and atherosclerotic vascular disease-local vascular factors. Baillieres Clin Endocrinol Metab. 1993;7(chapter 4):47-59.
11. Mendelsohn ME, Karas RH. Estrogens and the blood vessel wall. Curr Opin Cardiol. 1994;9:619-626.
12. Kushwaha RS, Hazzard WR. Exogenous estrogens attenuate dietary hypercholesterolemia and atherosclerosis in the rabbit. Metabolism. 1981; 30:359-366.
13. Haarbo J, Leth-Espersen P, Stender S, Christiansen C. Estrogen monotherapy and combined estrogen-progestogen replacement therapy attenuate aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits. J Clin Invest. 1991;87:1274-1279.
14. Haarbo J, Svendsen OL, Christiansen C. Progestogens do not affect aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits. Circ Res. 1992;70:1198-1202.
15. Sulistiyani, Adelman SJ, Chandrasekaran A, Jayo J, St Clair RW. Effect of 17α:-dihydroequilin sulfate, a conjugated equine estrogen, and ethinylestradiol on atherosclerosis in cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol. 1995;15:837-846.
16. Clarkson TB, Prichard RW, Morgan TM, Petrick GS, Klein KP. Remodeling of coronary arteries in human and nonhuman primates. JAMA. 1994;271:289-294.