Marimastat inhibits neointimal thickening in a model of human vein graft stenosis

British Journal of Surgery

Volumn 85, Issue 10, 1998, Pages 1373-1377

  Porter, K E ^a   Loftus, I M ^a   Peterson, M ^a   Bell, P R F ^a   London, N J M ^a   Thompson, M M ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GELATIN; MARIMASTAT; METALLOPROTEINASE;

ARTERY INTIMA PROLIFERATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; HISTOLOGY; HUMAN; HUMAN TISSUE; INTIMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SAPHENOUS VEIN GRAFT; TISSUE CULTURE;

CELLS, CULTURED; ENZYME INHIBITORS; GRAFT OCCLUSION, VASCULAR; HUMANS; HYDROXAMIC ACIDS; IMMUNOHISTOCHEMISTRY; SAPHENOUS VEIN; TUNICA INTIMA;

EID: 0031695573     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2168.1998.00888.x     Document Type: Article

References (40)

1. Varty K, Allen KE, Bell PRF, London NJM. Infrainguinal vein graft stenosis. Br J Surg 1993; 80: 825-33.
2. Clowes AW, Clowes MM, Fingerle J, Reidy MA. Kinetics of cellular proliferation after arterial injury. V. Role of acute distension in the induction of smooth muscle proliferation. Lab Invest 1989; 60: 360-4.
3. Clowes AW, Schwartz SM. Significance of quiescent smooth muscle migration in the injured rat carotid artery. Circ Res 1985; 56: 139-45.
4. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest 1983; 49: 327-33.
5. Clowes AW, Reidy MA, Clowes MM. Mechanism of stenosis after arterial injury. Lab Invest 1983; 49: 208-15.
6. Ross R. The pathogenesis of atherosclerosis - a perspective for the 1990s. Nature 1993; 362: 801-9.
7. Chan P. Cell biology of human vascular smooth muscle. Ann R Coll Surg Engl 1994; 76: 298-303.
8. Porter KE, Varty K, Jones L, Bell PRF, London NJM. Human saphenous vein organ culture: a useful model of intimal hyperplasia? Eur J Vasc Endovasc Surg 1996; 11: 48-58.
9. Carey DJ. Control of growth and differentiation of vascular cells by extracellular matrix proteins. Annu Rev Physiol 1991; 53: 161-77.
10. Campbell JH, Black MJ, Campbell GR. Replication of smooth muscle cells in atherosclerosis and hypertension. In: Meyer P, Marche P, eds. Blood Cells and Arteries in Hypertension and Atherosclerosis. New York: Raven Press, 1989: 15-33.
11. Southgate KM, Davies M, Booth RFG, Newby AC. Involvement of extracellular-matrix-degrading metalloproteinases in rabbit aortic smooth-muscle cell proliferation. Biochem J 1992; 288: 93-9.
12. Newby AC, Southgate KM, Davies M. Extracellular matrix degrading metalloproteinases in the pathogenesis of arteriosclerosis. Basic Res Cardiol 1994; 89(Suppl 1): 59-70.
13. Galis ZS, Muszynski M, Sukhova G, Simon Morrissey E, Unemori EN, Lark MW et al. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res 1994; 75: 181-9.
14. Sperti G, van Leeuwen RTJ, Quax PHA, Maseri A, Kluft C. Cultured rat aortic vascular smooth muscle cells digest naturally produced extracellular matrix. Involvement of plasminogen-dependent and plasminogen-independent pathways. Circ Res 1992; 71: 385-92.
15. Evans CH, Georgescu HI, Lin CW, Mendelow D, Steed DL, Webster MW. Inducible synthesis of collagenase and other neutral metalloproteinases by cells of aortic origin. J Surg Res 1991; 51: 399-404.
16. Murphy G, Docherty AJP. The matrix metalloproteinases and their inhibitors. Am J Respir Cell Mol Biol 1992; 7: 120-5.
17. Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI. SV40-transformed human lung fibroblasts secrete a 92kDa type IV collagenase which is identical to that secreted by normal human macrophages. J Biol Chem 1989; 264: 17213-21.
18. Burke JM, Ross R. Synthesis of connective tissue macromolecules by smooth muscle. International Review of Connective Tissue Research 1979; 8: 119-57.
19. Bendeck MP, Zempo N, Clowes AW, Galardy RE, Reidy MA. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ Res 1994; 75: 539-45.
20. Bendeck MP, Irvin C, Reidy MA. Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury. Circ Res 1996; 78: 38-43.
21. Varty K, Allen KE, Jones L, Sayers RD, Ratliff DA, Bell PRF et al. The influence of low molecular weight heparin on neointimal proliferation in cultured human saphenous vein. Eur J Vasc Surg 1994; 8: 174-8.
22. Allen KE, Varty K, Jones L, Sayers RD, Bell PRF, London NJM. Human venous endothelium can promote intimal hyperplasia in a paracrine manner. J Vasc Surg 1994; 19: 577-84.
23. Fabunmi RP, Baker AH, Murray EJ, Booth RFG, Newby AC. Divergent regulation by growth factors and cytokines of 95 kDa and 72 kDa gelatinases and tissue inhibitors of metalloproteinases-1, -2, -3 in rabbit aortic smooth muscle cells. Biochem J 1996; 315: 335-42.
24. Porter KE, Thompson MM, McDermott E, Jones L, Crowther M, Bell PRF et al. Production and inhibition of the gelatinolytie matrix metalloproteinases in a human model of vein graft stenosis. Eur J Vasc Endovasc Surg 1998 (in press).
25. Vine N, Powell JT. Metalloproteinases in degenerative aortic disease. Clin Sci 1991; 81: 233-9.
26. Wills A, Thompson MM, Crowther M, Brindle NP, Nasim A, Sayers RD et al. Elastase-induced matrix degradation in arterial organ cultures - an in vitro model of aneurysmal disease. J Vasc Surg 1996; 24: 667-79.
27. Bradford MM. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
28. Sayers RD, Jones L, Varty K, Allen K, Morgan JDT, Bell PRF et al. The histopathology of infrainguinal vein graft stenoses. Eur J Vasc Surg 1993; 7: 16-20.
29. Southgate KM, Fisher M, Banning AP, Thurston VJ, Baker AH, Fabunmi RP et al. Upregulation of basement membrane-degrading metalloproteinase secretion after balloon injury of pig carotid arteries. Circ Res 1996; 79: 1177-87.
30. Galis ZS, Sukhova GK, Kranzhofer R, Clark S, Libby P. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci USA 1995; 92: 402-6.
31. Brown DL, Hibbs MS, Kearney M, Loushin C, Isner JM. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation 1995; 91: 2125-31.
32. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994; 94: 2493-503.
33. George SJ, Zaltsman AB, Newby AC. Surgical preparative injury and neointima formation increase MMP-9 expression and MMP-2 activation in human saphenous vein. Cardiovasc Res 1997; 33: 447-59.
34. Forough R, Koyama N, Hasenstab D, Lea H, Clowes M, Nikkari S et al. Overexpression of tissue inhibitor of matrix metalloproteinase-1 inhibits vascular smooth muscle cell functions in vitro and in vivo. Circ Res 1996; 79: 812-20.
35. Kohler TR, Kirkman T, Kraiss LW, Zierler BK, Clowes AW. Increased blood flow inhibits neointimal hyperplasia in endothelialised vascular grafts. Circ Res 1991; 69: 1557-65.
36. Geary RL, Kohler TR, Vergel S, Kirkman TR, Clowes AW. Time course of flow-induced smooth muscle cell proliferation and intimai thickening in endothelialised baboon vascular grafts. Circ Res 1994; 74: 14-23.
37. Porter KE, Nydahl S, Dunlop P, Varty K, Thrush AJ, London NJM. The development of an in vitro flow model of human saphenous vein graft intimai hyperplasia. Cardiovasc Res 1996; 31: 607-14.
38. Murphy G. Matrix metalloproteinases and their inhibitors. Acta Orthop Scand 1995; 66(Suppl 266): 55-60.
39. Wojtowicz-Praga SM, Dickson RB, Hawkins MJ. Matrix metalloproteinase inhibitors. Invest New Drugs 1997; 15: 61-75.
40. Denis LJ, Verweij J. Matrix metalloproteinase inhibitors: present achievements and future prospects. Invest New Drugs 1997; 15: 175-85.