Low-level long-range 1H-15N heteronuclear shift correlation at natural abundance using submicro NMR techniques

Journal of Natural Products

Volumn 61, Issue 8, 1998, Pages 969-972

  Hadden, Chad E ^a   Martin, Gary E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELAVIRDINE; NITROGEN 15; PROTON; STRYCHNINE;

ARTICLE; BIOTECHNOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL NOISE RATIO;

EID: 0031695152     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np9802771     Document Type: Article

References (26)

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16. Martin, G. E.; Hadden, C. E.; Blinn, J. R.; Sharaf, M. H. M.; Tackie, A. N.; Schiff, P. L., Jr. Magn. Reson. Chem. 1998, 36, in press.
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22. 15N heteronuclear shift correlation data were reported in ref 21 for an 0.25 μmol sample of the alkaloid 11-isopropylcryptolepine that were acquired using SMIDG NMR probe technology. The correlation was detected using an intense N-methyl singlet, which is substantially easier to observe than correlations from some of the highly coupled proton multiplets of strychnine.
23. Ruiz-Cabello, J.; Vuister, G. W.; Moonen, C. T. W.; van Geldern, P.; Cohen, J. S.; van Zilj, P. C. M. J. Magn. Reson. 1992, 100, 282-302.
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25. Martin, G. E.; Crouch, R. C. Two-Dimensional NMR in Natural Products and Pharmaceutical Chemistry. In Two-Dimensional NMR Spectroscopy Applications for Chemists and Biochemists, 2nd ed.; Croasmun, W. R., Carlson, R. M. K., Eds.; VCH: New York, 1994; pp 886-897.
26. Farley, K. A.; Walker, G. S.; Martin, G. E. Magn. Reson. Chem. 1997, 35, 671-679.