Superoxide radical scavenging by phenolic bronchodilators under aprotic and aqueous conditions

Biochemical Pharmacology

Volumn 56, Issue 3, 1998, Pages 301-305

  Zwicker, Klaus ^a   Damerau, Werner ^b   Dikalov, Sergey ^c   Scholtyssek, Hardy ^b   Schimke, Ingolf ^d   Zimmer, Guido ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c INSTITUTE OF CHEMICAL KINETICS AND COMBUSTION   (Russian Federation)

^d HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Asthma; Beta agonists; Bronchodilators; EPR; Meta diphenols; Superoxide radicals

Indexed keywords

BRONCHODILATING AGENT; FENOTEROL; OXYFEDRINE; REPROTEROL; SALBUTAMOL; SUPEROXIDE; TERBUTALINE;

ANTIOXIDANT ACTIVITY; ARTICLE; ASTHMA; ELECTRON SPIN RESONANCE; IN VITRO STUDY; PRIORITY JOURNAL; ULTRAVIOLET SPECTROPHOTOMETRY;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; BRONCHODILATOR AGENTS; DRUG COMBINATIONS; ELECTRON SPIN RESONANCE SPECTROSCOPY; FENOTEROL; FREE RADICAL SCAVENGERS; ORCIPRENALINE; SUPEROXIDES; THEOPHYLLINE;

EID: 0031693573     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00029-X     Document Type: Article

References (14)

1. Barnes PJ. Reactive oxygen species and airway inflammation. Free Radic Biol Med. 9:1990;235-243.
2. del Maestro RF, Bjork I, Arfors KE. Increase in microvascular permeability induced by enzymatically generated free radicals. I. In vivo study. Microvasc Res. 22:1981;239-254.
3. Dikalov S, Khramtsov V, Zimmer G. Determination of rate constants of the reaction of thiols with superoxide radical by electron paramagnetic resonance: critical remarks on spectrophotometric approaches. Arch Biochem Biophys. 326:1996;207-218.
4. ·- with unsaturated fatty acids. J Biol Chem. 258:1983;4759-4769.
5. Aitkens J, Dix TA. Perhydroxyl radical initiated lipid peroxidation. The role of fatty acid hydroperoxides. J Biol Chem. 266:1991;15091-15098.
6. Gebicki JM, Bielski BHJ. Comparison of the capacities of the perhydroxyl and the superoxide radicals to initiate chain oxidation of linoleic acid. J Amer Chem Soc. 103:1981;7020-7022.
7. Graham DG, Tiffany SM, Bell WR, Gutknecht WF. Autoxidation versus covalent binding of quinones as a mechanism of toxicity of dopamine, 6-hydroxydopamine and related compounds toward C1300 Neuroblastoma cells in vivo. Mol Pharm. 14:1978;644-653.
8. Bors W, Saran M, Michel C, Lengfelder E, Fuchs C, Spoettl R. Pulse radiolytic investigations of catechols and catecholamines: adrenaline and adrenochrome. Int J Radiat Biol. 28:1975;353-371.
9. Niebch G, Obermeier K, Vergin H, Thiemer K. Untersuchungen zur Pharmakokinetik und Biotransformation von Reproterol bei Tier und Mensch. Arzneim-Forsch/Drug Res. 27:1977;37-45.
10. Jacks TJ, Hinojosa O. Superoxide radicals in intact tissues and in dimethyl sulfoxide-based extracts. Phytochemistry. 33:1993;563-568.
11. Kitagawa S, Kametani F, Tsuchiya K, Sakurai H. ESR analysis with long-chain alkyl spin labels in bovine blood platelets. Relationship between the increase in membrane fluidity by alcohols and phenolic compounds and their inhibitory effects on aggregation. Biochim Biophys Acta. 1027:1990;123-129.
12. Kitagawa S, Orinaka M, Hirata H. Depth-dependent change in membrane fluidity by phenolic compounds in bovine platelets and its relationship with their effects on aggregation and adenylate cyclase activity. Biochim Biophys Acta. 1179:1993;277-282.
13. Gillissen A, Jaworska M, Schaerling B, van Zwoll D, Schultze-Werninghaus G. Beta-2-agonists have antioxidant function in vivo. 1. Inhibition of superoxide anion, hydrogen peroxide, hypochlorous acid and hydroxyl radical. Respiration. 64:1997;16-22.
14. Gillissen A, Wickenburg D, van Zwoll D, Schultze-Werninghaus G. Beta-2-agonists have antioxidant function in vivo. 2. The effect of beta-2-agonists on oxidant-mediated cytotoxicity and on superoxide anion generated by human polymorphonuclear leukocytes. Respiration. 64:1997;23-28.