Nefiracetam prevents propofol-induced anterograde and retrograde amnesia in the rodent without compromising quality of anesthesia

Anesthesiology

Volumn 89, Issue 3, 1998, Pages 699-706

  O'Gorman, David A ^a   O'Connell, Alan W ^b   Murphy, Keith J ^b   Moriarty, Denis C ^a   Shiotani, Tadashi ^c   Regan, Ciaran M ^b  

^a MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Cognition enhancement; Neural cell adhesion molecule; Passive avoidance paradigm; Polysialylation

Indexed keywords

NEFIRACETAM; PROPOFOL;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTEROGRADE AMNESIA; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS ANESTHESIA; LEARNING; MALE; MEMORY CONSOLIDATION; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RETROGRADE AMNESIA; SIALYLATION;

AMNESIA; ANESTHESIA, INTRAVENOUS; ANESTHETICS, INTRAVENOUS; ANIMALS; COGNITION; MALE; PROPOFOL; PSYCHOTROPIC DRUGS; PYRROLIDINONES; RATS; RATS, WISTAR;

EID: 0031693216     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199809000-00021     Document Type: Article

References (41)

1. Johnstone R, Noseworthy T, Anderson B, Konopad E, Grace M: Propofol versus thiopental for outpatient anaesthesia. ANESTHESIOLOGY 1987; 67:431-3
2. Heath PJ, Kennedy DJ, Ogg TW, Dunling C, Gilks WR: Which intravenous induction agent for day surgery? Anesthesia 1988; 43: 365-8
3. Heath PJ, Ogg TW, Gilks WR: Recovery after day-case anesthesia. Anesthesia 1990; 45:911-5
4. Marais ML, Maher MW, Wetchler BV, Kortilla K, Apfelbaum JL: Reduced demands on recovery room resources with propofol (Diprivan) compared to thiopental-isoflurane. Anesthesiol Rev XVI 1989; 29-40
5. Sung Y-F, Reiss N, Tillette T: The differential cost of anesthesia and recovery with propofol-nitrous oxide anesthesia versus thiopental sodium-nitrous oxide anesthesia. J Clin Anesth 1991; 3:391-4
6. Korttila, K, Nuotto EJ, Lichtor JL, Östman, PL, Apfelbaum, JL, Rupani G: Clinical recovery and psychomotor function after brief anesthesia with propofol or thiopental. ANESTHESIOLOGY 1992; 76:676-81
7. Pang R, Quatermain D, Rosman E, Turndorf H: Effect of propofol on memory in mice. Pharmacol Biochem Behav 1993; 44:145-51
8. Zacny JP, Lichtor JL, Coalson DW, Finn RS, Uitvlugt AM, Glosten B, Flemming DC, Apfelbaum JL: Subjective and psychomotor effects of subanesthetic doses of propofol in healthy volunteers. ANESTHESIOLOGY 1992; 76:696-702
9. Bethune DW, Ghosh S, Gray B, Kerr L, Walker IA, Doolan LA, Harwood RJ, Sharples LD: Learning during general anaesthesia: Implicit recall after methohexitone or propofol infusion. Br J Anaesth 1992; 69:197-9
10. Polster MR, Gray PA, O'Sullivan G, McCarthy RA, Park GR: Comparison of the sedative and amnesic effect of midazolam and propofol. Br J Anaesth 1993; 70:612-6
11. Cork RC, Heaton JF, Campbell CE and Kihlstrom JF: Is there implicit memory after propofol sedation? Br J Anaesth 1996; 76:492-8
12. Sanou J, Goodall G, Capuron L, Bourdalle-Badie C, Maurette P: Cognitive sequelae of propofol anesthesia. NeuroReport 1996; 7:1130-2
13. Ogg TW, Fischer HBJ, Bethune DW, Collins JM: Day case anesthesia and memory. Anesthesia 1979; 34:784-9
14. Ogg, TW: Use of anaesthesia. Implications of day case surgery and anaesthesia. BMJ 1980; 281:212-4
15. Ghouri A, Ramirez Ruiz MA, White PF: Effect of flumazenil on recovery after midazolam and propofol sedation. ANESTHESIOLOGY 1994; 81:333-9
16. Rovira J: Economic analysis and pharmaceutical policy. Anesthesia 1995; 50:49-51
17. Yamada K, Nabeshima T: Nefiracetam (DM-9384): A novel antiamnesic drug. CNS Drug Rev 1996; 2:322-42
18. Mondadori C, Hengerer B, Ducret T, Borkowski J: Delayed emergence of effects of memory enhancing drugs: Implications for the dynamics of long term memory. Proc Natl Acad Sci U S A 1994; 91:2041-5
19. Mondadori C, Petschke F: Do piracetam-like compounds act centrally via peripheral mechanisms? Brain Res 1987; 435:310-4
20. Doyle E, Regan CM, Shiotani T: Nefiracetam (DM-9384) preserves hippocampal neural cell adhesion molecule-mediated memory consolidation processes during scopolamine disruption of passive avoidance training in the rat. J Neurochem 1993; 61:266-72
21. Fox GB, O'Connell AW, Murphy KJ, Regan CM: Memory consolidation induces a transient and time-dependent increase in the frequency of NCAM polysialylated cells in the adult rat hippocampus. J Neurochem 1995; 65:2796-9
22. Murphy KJ, O'Connell AW, Regan CM: Repetitive and transient increases in hippocampal neural cell adhesion molecule polysialylation state following multi-trial spatial training. J Neurochem 1996; 67:1268-74
23. Odumeru O, Murphy KJ, O'Connell AW, Regan CM, Shiotani T: Influence of nefiracetam on NGF-induced neuritogenesis and neural cell adhesion molecule polysialic acid expression: In vivo and in vitro comparisons. Behav Brain Res 1997; 83:173-8
24. Bailey CH, Kandel ER: Structural changes accompanying memory storage. Annu Rev Physiol 1993; 55:397-426
25. Rougon G, Dubois C, Buckley N, Magnani JL, Zollinger W: A monoclonal antibody against meningococcus group B polysaccharides distinguishes embryonic from adult N-CAM. J Cell Biol 1986; 103: 2429-37
26. O'Connell C, O'Malley A, Regan CM: Transient, learning-induced ultrastructural change in spatially-clustered dentate granule cells of the adult rat hippocampus. Neurosci 1997; 76:55-62
27. Noble J, Ogg TW: The effect of propofol (Diprivan) and methohexitone on memory after day-case anaesthesia. Postgrad Med J 1985; 61:103-4
28. Doyle E, O'Boyle KM, Shiotani T, Regan CM: Nefiracetam (DM-9384) reverses apomorphine-induced amnesia of a passive avoidance response: Delayed emergence of the memory retention effects. Neurochem Res 1996; 21:649-52
29. Spignoli G, Pepeu G: Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine. Pharmacol Biochem Behav 1987; 27:491-5
30. Woodruff-Pak DS, Hinchcliffe RM: Mecamylamine- or scopolamine-induced learning impairment: Ameliorated by nefiracetam. Psychopharmacology 1997; 131:130-9
31. Funk KF, Schmidt J: Changes of dopamine metabolism by hypoxia and effect of nootropic drugs. Biomed Biochem Acta 1984; 11: 1301-4
32. Marchi M, Besana E, Raiteri M: Oxiracetam increases the release of endogenous glutamate from depolarized rat hippocampal slices. Eur J Pharmacol 1990: 185:247-9
33. Nabeshima T, Noda Y, Tohyama K, Itoh J, Kameyama T: Effects of DM-9384 in a model of amnesia based on animals with GABAergic dysfunctions. Eur J Pharmacol 1990; 178:143-9
34. Concas A, Santoro G, Mascia MP, Serra M, Sanna E, Biggio G: The general anesthetic propofol enhances the function of γ-aminobutyric acid-coupled chloride channel in the rat cerebral cortex. J Neurochem 1990; 55:2135-6
35. Ogg TW: An assessment of postoperative outpatient cases. BMJ 1972; 4:573-6
36. Kitz DS, Slusarz-Ladden C, Lecky JH: Hospital resources used for inpatient and ambulatory surgery. ANESTHESIOLOGY 1988; 69:383-6
37. Korttila K: Recovery from outpatient anesthesia. Factors affecting outcome. Anesthesia 1995; 50:22-8
38. Korttila K, Östman P, Faure E, Apfelbaum JL, Prunski J, Ekdawi M, Roizen MF: Randomised comparison of recovery after propofol-nitrous oxide versus thiopentone-isoflurane-nitrous oxide anesthesia in patients undergoing ambulatory surgery. Acta Anesthesiol Scand 1990; 34:400-3
39. Kain ZN, Gaal DJ, Kain TS, Jaeger DD, Rimar S: A first-pass cost analysis of propofol versus barbiturates for children undergoing magnetic resonance imaging. Anesth Analg 1994; 79:1102-6
40. Riddell PL, Robertson GS: Use of doxapram as an arousal agent in outpatient general anaesthesia. Br J Anaesth 1978; 50:921-4
41. Gürel A, Elevli M, Hamulu A: Aminophylline reversal of flunitrazepam sedation. Anesth Analg 1987; 66:333-6