Detection of doxepin and its major metabolite desmethyldoxepin in hair following drug therapy

Journal of Analytical Toxicology

Volumn 22, Issue 6, 1998, Pages 531-536

  Negrusz, Adam ^a   Moore, Christine M ^b   Perry, Jennifer L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b United States Drug Testing Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXEPIN; NORDOXEPIN;

ACCURACY; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; HAIR; HUMAN; HUMAN TISSUE; MASS SPECTROMETRY; SOLID PHASE EXTRACTION;

EID: 0031689388     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/22.6.531     Document Type: Article

References (17)

1. The Complete Reference for Generic and Brand Drugs. Mosby, Chicago, IL, 1998, pp II-750-II-753.
2. S.H. Richeimer, Z.H. Bajwa, S.S. Kahraman, B.J. Ransil, and C.A. Warfield. Utilization patterns of tricyclic antidepressants in a multidisciplinary pain clinic: a survey. Clin. J. Pain 13: 324-329 (1997).
3. R.A. Sabroe, C.T. Kennedy, and C.B. Archer. The effects of topical doxepin on responses to histamine, substance P and prostaglandin E2 in human skin. Br. J. Dermatol. 137: 386-390 (1997).
4. S.H. Preskorn and G.A. Fast. Therapeutic drug monitoring for antidepressants: efficacy, safety, and cost effectiveness. J. Clin. Psychiatry 52(6 Suppl.): 23-33 (1991).
5. V.E. Ziegler, J.T. Biggs, L.T. Wylie, S.H. Rosen, D.J. Hawf, and W.H. Coryell. Doxepin kinetics. Clin. Pharmacol. Ther. 23: 573-579 (1978).
6. M.R. Jarvis. Clinical pharmacokinetics of tricyclic antidepressant overdose. Psychopharmacol. Bull. 27: 541-550 (1991).
7. J.C. Nelson. Current status of tricyclic antidepressants in psychiatry: their pharmacology and clinical applications. J. Clin. Psychiatry 52: 193-200 (1991).
8. C.L. DeVane, M.V. Rudorfer, and W.Z. Potter. Dosage regimen design for cyclic antidepressants: a review of pharmacokinetic methods. Psychopharmacol. Bull. 27: 619-631 (1991).
9. L. Ereshefsky, T. Tran-Johnson, C.M. Davis, and A. LeRoy. Pharmacokinetic factors affecting antidepressant drug clearance and clinical effect: evaluation of doxepin and imipramine - new data and review. Clin. Chem. 34: 863-880 (1988).
10. N.A. Buckley, A.H. Dawson, I.M. Whyte, and D.A. Henry. Greater toxicity in overdose of dothiepin than of other tricyclic antidepressants. Lancet 343: 159-162 (1994).
11. S.P. Roose, G.W. Dalack, A.H. Glossman, S. Woodring, B.T. Walsh, and E.G. Giardina. Is doxepin a safer tricyclic for the heart? J. Clin. Psychiatry 52: 338-341 (1991).
12. G.D. Tollefson. Antidepressant treatment and side effect considerations. J. Clin. Psychiatry 52(5 Suppl.): 4-13 (1991).
13. M. Callaham and D. Kassel. Epidemiology of fatal tricyclic antidepressant ingestion: implications for management. Ann. Em. Med. 14: 1-9 (1985).
14. T.L. Litovitz, L. Felberg, S. White, and W. Klein-Schwartz. 1995 Annual report of the American Association of Poison Control Centers toxic exposure surveillance system. Am. J. Em. Med. 14: 487-537 (1996).
15. T.L. Litovitz, B.F. Schmitz, N. Matyunas, and T.G. Martin. 1987 Annual report of the American Association of Poison Control Centers national data collection system. Am. J. Em. Med. 6: 479-515 (1988).
16. F.J. Couper, I.M. McIntyre, and O.H. Drummer. Detection of antidepressant and antipsychotic drugs in postmortem human scalp hair. J. Forensic Sci. 40: 87-90 (1995).
17. F. Pragst, M. Rothe, J. Hunger, and S. Thor. Structural and concentration effects on the deposition of tricyclic antidepressants in human hair. Forensic Sci. Int. 84: 225-236 (1997).