Assessment of myocardial glutamate requirements early after coronary artery bypass surgery

Scandinavian Cardiovascular Journal

Volumn 32, Issue 3, 1998, Pages 145-152

  Vanhanen, Ingemar ^a   Svedjeholm, Rolf ^a   Håkanson, Erik ^a   Joachimsson, P O ^b   Jorfeldt, Lennart ^c   Nilsson, Lennart ^a   Vanky, Farkas ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adverse effects; Biological transport; Cardiac surgery; Coronary artery disease; Dose response; Human glutamate; Metabolism; Myocardium

Indexed keywords

GLUTAMIC ACID;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CORONARY ARTERY BYPASS SURGERY; CORONARY ARTERY DISEASE; HEART MUSCLE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL; TRANSPORT AT THE CELLULAR LEVEL;

AGED; CORONARY ARTERY BYPASS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTAMIC ACID; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MYOCARDIUM; POSTOPERATIVE COMPLICATIONS; STROKE VOLUME;

EID: 0031689103     PISSN: 14017431     EISSN: None     Source Type: Journal    
DOI: 10.1080/14017439850140102     Document Type: Article

References (31)

1. Aoki TT, Brennan MF, Müller WA, Moore FD, Cahill J,GF. Effect of insulin on muscle glutamate uptake. Whole blood versus plasma glutamate analysis. J Clin Invest 1972; 51: 2889-2894.
2. Bernt E, Bergmayer HU. L-Glutamat: UV-test mit Glutamat-Dehydrogenase und NAD. In: Bergmayer HU, ed. Metoden der enzymatischen analyse. 3rd Ed. Weinheim: Verlag Chemie GMBH, 1974: 1749-1753.
3. Beyersdorf F, Kirsh M, Buckberg GD, Allen BS. Warm glutamate/aspartate-enriched blood cardioplegic solution for perioperative sudden death. J Thorac Cardiovasc Surg 1992; 104: 1141-1147.
4. Beyersdorf F, Sarai K, Maul FD, Wendt T, Satter P. Immediate functional benefits after controlled reperfusion during surgical revascularization for acute coronary occlusion. J Thorac Cardiovasc Surg 1991; 102: 856-866.
5. Bittl J, Shine K. Protection of ischemic rabbit myocardium by glutamic acid. Am J Physiol 1983; 245: H406-H412.
6. Daabees TT, Finkelstein MW, Stegink LD, Applebaum AE. Correlation of glutamate plus aspartate dose, plasma amino acid concentration and neuronal necrosis in infant mice. Food Chem Toxicol 1985; 23: 887-893.
7. Dinkelborg LM, Kinne RK, Grieshaber MK. Characterization and pH dependence of L-glutamate transport in sarcolemmal vesicles from rat hearts. Am J Physiol 1995; 268: H194-201.
8. Ganz W, Tamura K, Marcus HS, Donoso R, Yoshida S, Swan JC. Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation 1971; 19: 181-195.
9. Jorfeldt L, Juhlin-Dannfelt A. The influence of ethanol on splanchnic and skeletal muscle metabolism in man. Metabolism 1978; 27: 97-106.
10. Kenney RA, Tidball CS. Human susceptibility to oral monosodium L-glutamate. Am J Clin Nutr 1972; 25: 140-146.
11. Kimose HH, Ravkilde J, Helligsö P, et al. Myocardial loss of glutamate after cold chemical cardioplegia and storage in isolated blood-perfused pig hearts. Thorac Cardiovasc Surg 1993; 41: 93-100.
12. Kjellman UW, Björk K, Ekroth R, et al. Addition of a-Ketoglutarate to blood cardioplegia improves cardio-protection. Ann Thorac Surg 1997; 63: 1625-1634.
13. Knapp WH, Helus F, Ostertag H, Tillmans H, Kubler W. Uptake and turnover L-( 13N)-glutamate in the normal human heart and in patients with coronary artery disease. Eur J Nucl Med 1982; 7: 211-215.
14. Lazar HL, Buckberg GD, Manganaro AJ, Becker H, Maloney JVJ. Reversal of ischemic damage with amino acid substrate enhancement during reperfusion. Surgery 1980; 80: 702-709.
15. Loop FD, Higgins TL, Panda R, Pearce G, Estafanous FG. Myocardial protection during cardiac operations: Decreased morbidity and lower cost with blood cardioplegia and coronary sinus perfusion. J Thorac Cardiovasc Surg 1992; 104: 608-618.
16. Low SY, Rennie MJ, Taylor PM. Sodium-dependent glutamate transport in cultured rat myotubes increases after glutamine deprivation. FASEB J 1994; 8: 127-131.
17. Mudge GH, Mills RM, Taegtmeyer H, Gorlin R, Lesch M. Alterations of myocardial amino acid metabolism in chronic ischemic heart disease. J Clin Invest 1976; 58: 1185-1192.
18. Pisarenko OI, Lepilin MG, Ivanov VE. Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure. Clin Science 1986; 70: 7-12.
19. Rau E, Shine KI, Gervais A, Douglas AM, Amos EC. Enhanced mechanical recovery of anoxic and ischemic myocardium by amino acid perfusion. Am J Physiol 1979; 236: H873-H879.
20. Safer B. The metabolic significance of the malate-aspartate cycle in heart. Circ Res 1975; 37: 527-533.
21. Schaumburg HH, Byck R, Gerstl R, Mashman JH. Monosodium L-glutamate: Its pharmacology and role in the Chinese restaurant syndrome. Science 1969; 163: 826-828.
22. Stegink LD, Filer Jr LJ, Baker GL. Effect of carbohydrate on plasma and erythrocyte glutamate levels in humans ingesting large doses of monosodium L-glutamate in water. Am J Clin Nutr 1983; 37: 961-968.
23. Suleiman MS, Dihmis WC, Caputo M, Angelini D, Bryan AJ. Changes in myocardial concentration of glutamate and aspartate during coronary artery surgery. Am J Physiol 1997; 272: H1063-1069.
24. Svedjeholm R. Myocardial uptake of substrates early after cardiac surgery. A clinical study of metabolic derangement and recovery with special reference to effects of dopamine and insulin. Uppsala University (Thesis) 1990: 7-54.
25. Svedjeholm R, Ekroth R, Joachimsson PO, Ronquist G, Svensson SE, Tydén H. Myocardial uptake of amino acids and other substrates in relation to myocardial oxygen consumption four hours after cardiac surgery. J Thorac Cardiovasc Surg 1991; 101: 688-694.
26. Svedjeholm R, Svensson SE, Ekroth R, et al. Trauma metabolism and the heart; studies of heart and leg amino acid flux after cardiac surgery. Thorac Cardiovasc Surg 1990; 38: 1-5.
27. Svedjeholm R, Vanhanen I, Håkanson E, Joachimsson PO, Jorfeldt L, Nilsson L. Metabolic and hemodynamic effects of intravenous glutamate infusion early after coronary surgery. J Thorac Cardiovasc Surg 1996; 112: 1468-1477.
28. Thomassen AR. Myocardial uptake and effects of glutamate during non-ischaemic and ischaemic conditions. A clinical study with special reference to possible interrelationships between glutamate and myocardial utilization of carbohydrate substrates. Dan Med Bull 1992; 39: 471-488.
29. Thomassen A, Bötker HE, Nielsen TT, Thygesen K, Henningsen P. Effects of glutamate on exercise tolerance and circulating substrate levels in stable angina pectoris. Am J Cardiol 1990; 65: 173-178.
30. Thomassen A, Nielsen TT, Bagger JP, Henningsen P. Effects of intravenous glutamate on substrate availability and utilization across the human heart and leg. Metabolism 1991; 40: 378-384.
31. Thomassen A, Nielsen TT, Bagger JP, Pedersen AK, Henningsen P. Antiischemic and metabolic effects of glutamate during pacing in patients with stable angina pectoris secondary to either coronary artery disease or syndrome X. Am J Cardiol 1991; 68: 291-295.