Quantitative trait locus analysis: A new tool for psychiatric genetics

Neuroscientist

Volumn 4, Issue 5, 1998, Pages 317-323

  Brodkin, Edward S ^b   Nestler, Eric J ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c Yale University School of Medicine   (United States)

Author keywords

Behavioral genetics; Psychiatric genetics; Quantitative trait locus (QTL)

Indexed keywords

ANIMAL MODEL; BEHAVIOR GENETICS; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENOTYPE; HUMAN; MENTAL DISEASE; NONHUMAN; QUANTITATIVE TRAIT; REVIEW;

EID: 0031687322     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385849800400511     Document Type: Review

References (28)

1. Nurnberger JI Jr, Goldin LR, Gershon ES. Genetics of psychiatric disorders. In: Winokur G, Clayton P, editors. The medical basis of psychiatry. New York: WB Saunders; 1986. p. 486-521.
2. Plomin R, Owen MJ, McGuffin P. The genetic basis of complex human behaviors. Science 1994;264:1733-1739.
3. Comings DE: Polygenic inheritance in psychiatric disorders. In: Blum K, Noble EP, editors. Handbook of psychiatric genetics. Boca Raton (FL): CRC Press; 1997. p. 235-260.
4. American Psychiatric Association, Diagnostic and statistical manual of mental disorders, 4th ed (DSM-IV). Washington (DC): American Psychiatric Association; 1994.
5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
6. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903-908.
7. Rosenbaum M, Leibel RL, Hirsch J. Obesity. N Engl J Med 1997;337:396-407.
8. Belknap JK, Dubay C, Crabbe JC, Buck KJ. Mapping quantitative trait loci for behavioral traits in the mouse. In: Blum K, Noble EP, editors. Handbook of psychiatric genetics. Boca Raton (FL): CRC Press; 1997. p. 435-153.
9. Silver LM. Mouse genetics: concepts and applications. New York: Oxford University Press; 1995.
10. Lander ES, Botstein D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 1989; 121:185-199.
11. Lander E, Kmglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-247.
12. Falconer DS, Mackay TFC. Introduction to quantitative genetics. 4th ed. New York: Longman Scientific and Technical, John Wiley & Sons; 1996.
13. Paterson AH, Lander ES, Hewitt JD, Peterson S, Lincoln SE, Tanksley SD. Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature 1988;335:721-726.
14. Berrettini WH, Ferraro TN, Alexander RC, Buchberg AM, Vogel WH. Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Nat Genet 1994;7:54-58.
15. Frankel WN, Valenzuela A, Lutz CM, Johnson EW, Dietrich WF, Coffin JM. New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm Genome 1995;6:830-838.
16. Flint J, Corley R, DeFries JC, et al. A simple genetic basis for a complex psychological trait in laboratory mice. Science 1995;269:1432-1435.
17. Melo JA, Shendure J, Pociask K, Silver LM. Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nat Genet 1996; 13:147-153.
18. Moisan M-P, Courvoisier H, Bihoreau M-T, et al. A major quantitative trait locus influences hyperactivity in the WKHA rat. Nat Genet 1996;14:471-473.
19. Remmers EF, Longman RE, Du Y, et al. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Nat Genet 1996;14:82-85.
20. Wehner JM, Radcliffe RA, Rosmann ST, et al. Quantitative trait locus analysis of contextual fear conditioning in mice. Nat Genet 1997;17:331-334.
21. Buck KJ, Metten P, Belknap JK, Crabbe JC. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci 1997;17:3946-3955.
22. Gershenfeld HK, Neumann PE, Mathis C, Crawley JN, Li X, Paul SM. Mapping quantitative trait loci for open-field behavior in mice. Behav Genet 1997;27:20I-210.
23. Ferraro TN, Golden GT, Smith GG, et al. Mapping murine loci for seizure response to kainic acid. Mamm Genome 1997;8: 200-208.
24. Dietrich WF, Miller JC, Steen RG, et al. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nat Genet 1994;7:220-245.
25. Jacob HJ, Brown DM, Bunker RK, et al. A genetic linkage map of the laboratory rat, Rattus non-egicus. Nat Genet 1995;9:63-69.
26. Lander ES, Green P, Abrahamson J, et al. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1987;I:174-181.
27. Darvasi A, Soller M. Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 1995;141: 1199-1207.
28. King DP, Zhao Y, Sangoram AM, et al. Positional cloning of the mouse circadian clock gene. Cell 1997;89:641-653.