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Volumn 28, Issue 8, 1998, Pages 779-784

Differential in vitro hepatic and intestinal metabolism of ifosfamide in the rat

Author keywords

[No Author keywords available]

Indexed keywords

IFOSFAMIDE; XENOBIOTIC AGENT;

EID: 0031686661     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982598239191     Document Type: Article
Times cited : (1)

References (17)
  • 1
    • 0027369366 scopus 로고
    • Differential activation of cyclophosphamide and ifosfamide by cytochromes P-450 2B and 3A in human liver microsomes
    • CHANG, T. K. H., WEBER, G. F., CRESPI, C. L. and WAXMAN, D. J., 1993, Differential activation of cyclophosphamide and ifosfamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Research, 53, 5629-5637.
    • (1993) Cancer Research , vol.53 , pp. 5629-5637
    • Chang, T.K.H.1    Weber, G.F.2    Crespi, C.L.3    Waxman, D.J.4
  • 2
    • 0031024382 scopus 로고    scopus 로고
    • Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4-potential contribution to high first-pass metabolism
    • FITZSIMMONS, M. E. and COLLINS, J. M., 1997, Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4-potential contribution to high first-pass metabolism. Drug Metabolism and Disposition, 25, 256-266.
    • (1997) Drug Metabolism and Disposition , vol.25 , pp. 256-266
    • Fitzsimmons, M.E.1    Collins, J.M.2
  • 3
    • 0023035082 scopus 로고
    • Dechloroethylation of ifosfamide and neurotoxicity
    • GOREN, M. P., WRIGHT, R. K.,PRATT, C. B. and PELL, P. E., 1986, Dechloroethylation of ifosfamide and neurotoxicity. Lancet, ii, 1219-1220.
    • (1986) Lancet , vol.2 , pp. 1219-1220
    • Goren, M.P.1    Wright, R.K.2    Pratt, C.B.3    Pell, P.E.4
  • 4
  • 5
    • 0028054999 scopus 로고
    • Extrahepatic metabolism of drugs in humans
    • KRISHNA, D. R. and KLOTZ, U., 1994, Extrahepatic metabolism of drugs in humans. Clinical Pharmacokinetics, 26, 144-160.
    • (1994) Clinical Pharmacokinetics , vol.26 , pp. 144-160
    • Krishna, D.R.1    Klotz, U.2
  • 9
    • 0026657789 scopus 로고
    • Cytochrome P-450-mediated N-dechloroethylation of cyclophosphamide and ifosfamide in the rat
    • RUZICKA, J. A. and RUENITZ, P. C., 1992, Cytochrome P-450-mediated N-dechloroethylation of cyclophosphamide and ifosfamide in the rat. Drug Metabolism and Disposition, 20, 770-772.
    • (1992) Drug Metabolism and Disposition , vol.20 , pp. 770-772
    • Ruzicka, J.A.1    Ruenitz, P.C.2
  • 10
    • 0028183382 scopus 로고
    • Ifosfamide clinical pharmacokinetics
    • WAGNER, T., 1994, Ifosfamide clinical pharmacokinetics. Clinical Pharmacokinetics, 26, 439-456.
    • (1994) Clinical Pharmacokinetics , vol.26 , pp. 439-456
    • Wagner, T.1
  • 11
  • 13
    • 0029012073 scopus 로고
    • Identification of new metabolites of ifosfamide in rat urine using ion cluster technique
    • WANG, J. H. and CHAN, K. K., 1995a, Identification of new metabolites of ifosfamide in rat urine using ion cluster technique. Journal of Mass Spectrometry, 30, 675-683.
    • (1995) Journal of Mass Spectrometry , vol.30 , pp. 675-683
    • Wang, J.H.1    Chan, K.K.2
  • 14
    • 0029557939 scopus 로고
    • Analysis of ifosfamide, 4-hydroxyifosfamide, N2-dechloroethylifosfamide, N3-dechloroethylifosfamide, and iphosphamide mustard in plasma by gas chromatography-mass spectrometry
    • WANG, J. H. and CHAN, K. K., 1995b, Analysis of ifosfamide, 4-hydroxyifosfamide, N2-dechloroethylifosfamide, N3-dechloroethylifosfamide, and iphosphamide mustard in plasma by gas chromatography-mass spectrometry. Journal of Chromatography, 674, 205-217.
    • (1995) Journal of Chromatography , vol.674 , pp. 205-217
    • Wang, J.H.1    Chan, K.K.2
  • 15
    • 0027174822 scopus 로고
    • Activation of the anti-cancer drug ifosfamide by rat liver microsomal P450 enzymes
    • WEBER, G. F. and WAXMAN, D. J., 1993, Activation of the anti-cancer drug ifosfamide by rat liver microsomal P450 enzymes. Biochemical Pharmacology, 45, 1685-1694.
    • (1993) Biochemical Pharmacology , vol.45 , pp. 1685-1694
    • Weber, G.F.1    Waxman, D.J.2
  • 16
    • 0030476592 scopus 로고    scopus 로고
    • Role of cytochrome P450 in oxazaphosphorine metabolism, deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochrome P450
    • YU, L. and WAXMAN, D. J., 1996, Role of cytochrome P450 in oxazaphosphorine metabolism, deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochrome P450. Drug Metabolism and Disposition, 24, 1254-1262.
    • (1996) Drug Metabolism and Disposition , vol.24 , pp. 1254-1262
    • Yu, L.1    Waxman, D.J.2
  • 17
    • 9044236908 scopus 로고    scopus 로고
    • Characterization of rat small intestinal cytochrome P450 composition and inducibility
    • ZHANG, Q. Y., WIKOFF, J., DUNBAR, D. and KAMINSKY, L., 1996, Characterization of rat small intestinal cytochrome P450 composition and inducibility. Drug Metabolism and Disposition, 24, 322-328.
    • (1996) Drug Metabolism and Disposition , vol.24 , pp. 322-328
    • Zhang, Q.Y.1    Wikoff, J.2    Dunbar, D.3    Kaminsky, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.