Continuous blood withdrawal as a rapid screening method for determining clearance and oral bioavailability in rats

Pharmaceutical Research

Volumn 15, Issue 8, 1998, Pages 1257-1261

  Humphreys, W Griffith ^a   Obermeier, Mary T ^a   Morrison, Richard A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Continuous withdrawal; Drug discovery; Rapid screening methods

Indexed keywords

5 DIMETHYLAMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 1 NAPHTHALENESULFONAMIDE; ATENOLOL; PROPRANOLOL; THEOPHYLLINE; WARFARIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG SCREENING; INTRAARTERIAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; ATENOLOL; BIOLOGICAL AVAILABILITY; MALE; PROPRANOLOL; RATS; RATS, SPRAGUE-DAWLEY; THEOPHYLLINE; WARFARIN;

EID: 0031686519     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011900210241     Document Type: Article

References (15)

1. A. Kowarski, R. G. Thompson, C. J. Migeon, and R. M. Blizzard. Determination of Integrated Plasma Concentrations and True Secretion Rates of Human Growth Hormone. J. Clin. Endocrinol. Metab. 32:356-360 (1971).
2. C. R. Kowarski, C. Giancatarino, R. Kreamer, D. Brecht, and A. Kowarski. Measurement of Sulfamethizole Clearance Rate by Nonthrombogenic Constant Blood-Withdrawal System. J. Pharm. Sci. 65:450-452 (1976).
3. B. Vogelstein, A. A. Kowarski, and P. S. Lietmen. Continuous Sampling as a Pharmacokinetic Tool. Clin. Pharmacol. Ther. 22:131-138 (1977).
4. C. R. Kowarski and A. A. Kowarski. Constant Blood Withdrawal Method for Area Under Plasma Concentration-Time Curve. J. Pharm. Sci. 67:875-876 (1978).
5. Y. Gomita, K. Furuno, K. Eto, M. Okazaki, K. Suemaru, and Y. Araki. Effects of Cigarette Smoking on Theophylline Pharmocokinetics in Rats. J. Pharm. Pharmacol. 43:621-624 (1991).
6. D. Jung and M. Nanavaty. Effects of Age and Dietary Protein Restriction on the Pharmacokinetics of Theophylline in the Rat. Pharmacol and Toxicol 66:361-366 (1990).
7. M. I. Al-Hassan, S. A. Bawazir, K. M. Matar, and A. Tekle. Effects of Famotidine on Theophylline Pharmacokinetics in the Rat. Int. J. Pharm. 50:35-38 (1989).
8. K. P. Thadikonda, C. A. Lau-Cam, V. L. Thadikonda, and V. Theofanopoulos. Nasal Delivery of Atenolol and Timolol in the Rat and Effects of Absorption Enhancers. Drug. Dev. and Indust. Pharmacy. 21:349-360 (1995).
9. F. M. Belpaire, F. De Smet, L. J. Vynckier, A. M. Vermuelen, M. T. Rosseel, M. G. Bogaert, and L. Chauvelot-Moachon. Effects of Aging on the Pharmacokinetics of Atenolol, Metoprolol, and Propranolol in the Rat. J. Pharmacol. Exp. Ther. 254:116-122 (1990).
10. K. Iwamoto, J. Watanabe, K. Araki, N. Deguchi, and H. Sugiyama. Effects of Age on the Hepatic Clearance of Propranolol in Rats. J. Pharm. Pharmacol. 37:466-470 (1985).
11. G. Levy and A. Yacobi. Comparative Pharmacokinetics of Coumarin Anticoaggulants XIV: Relationship Between Protein Binding. Distribution, and Elimination Kinetics of Warfarin in Rats. J. Pharm. Sci. 63:805-806 (1974).
12. A. C. T. Lo, K. Chan, J. H. K. Yeung, and K. S. Woo. The Effects of Danshen (Salvia miltiorrhiza) on Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. Eur. J. Drug Metab. and Pharmacokin. 17:257-262 (1992).
13. G. A. Grode, S. J. Anderson, H. M. Grotta, and R. D. Falb. Nonthrombogenic Materials via a Simple Coating Process. Trans. Amer. Soc. Artif. Int. Organs 15:1-6 (1969).
14. J. Berman, K. Halm, K. Adkinson, and J. Scaffer. Simultaneous Pharmacokinetic Screening of a Mixture of Compounds in the Dog Using API LC/MS/MS Analysis for Increased Throughput. J. Med. Chem. 40:827-829 (1997).
15. T. V. Olah, D. A. McLoughlin, and J. D. Gilbert. The Simultaneous Determination of Mixtures of Drug Candidates by Liquid Chromatography/Atmospheric Pressure Chemical Ionization Mass Spectrometry as an In Vivo Drug Screening Procedure. Rapid Comm. Mass Spectro. 11:17-23 (1997).