Ethanol selectively counteracts hypotension evoked by central I1- Imidazoline but not α2-adrenergic receptor activation in spontaneously hypertensive rats

Journal of Cardiovascular Pharmacology

Volumn 32, Issue 3, 1998, Pages 382-389

  El Mas, Mahmoud M ^a   Abdel Rahman, Abdel A ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Methylnorepinephrine; Blood pressure; Clonidine; Ethanol; Rilmenidine

Indexed keywords

ALCOHOL; ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; CORBADRINE; IMIDAZOLINE; RILMENIDINE;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE THERAPY; ARTICLE; DRUG EFFECT; DRUG RECEPTOR BINDING; HYPERTENSION; INTRACISTERNAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; BLOOD PRESSURE; BRAIN; CLONIDINE; ETHANOL; HEART RATE; HYPERTENSION; MALE; NORDEFRIN; OXAZOLES; RATS; RATS, INBRED SHR; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DRUG;

EID: 0031684729     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199809000-00008     Document Type: Article

References (45)

1. 2-Adrenoceptors: classification, localization, mechanisms and targets for drugs. J Med Chem 1982;25:1389-401.
2. Chan CKS, Sannajust F, Head GA. Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits. J Pharmacol Exp Ther 1996;276:411-20.
3. Bousquet P, Feldman J, Tibirica E, et al. Imidazoline receptors: a new concept in central regulation of the arterial blood pressure. Am J Hypertens 1992;5:47S-50S.
4. Bousquet P, Feldman J, Schwartz J. Central cardiovascular effects of α-adrenergic drugs: differences between catecholamines and imidazolines. J Pharmacol Exp Ther 1984;230:232-6.
5. 1-imidazoline receptors. J Cardiovasc Pharmacol 1992; 20(suppl4):S1-10.
6. Ernsberger P, Giuliano R, Willette RN, Reis DJ. Role of imidazole receptors in the vasodepressor responses to clonidine analogs in the rostral ventrolateral medulla. J Pharmacol Exp Ther 1990;253: 408-18.
7. 1-imidazoline sites. J Pharmacol Exp Ther 1993; 264:172-82.
8. 1) receptors as targets of centrally acting antihypertensives: moxonidine and rilmenidine. J Hypertens 1997;15:117-25.
9. El-Mas MM, Tao S, Carroll RG, Abdel-Rahman AA. Ethanol-clonidine hemodynamic interaction in normotensive rats is modified by anesthesia. Alcohol 1994;11:307-14.
10. El-Mas MM, Abdel-Rahman AA. Contrasting effects of urethane, ketamine, and thiopental anesthesia on ethanol-clonidine hemodynamic interaction. Alcohol Exp Clin Res 1997;21:19-27.
11. Abdel-Rahman AA. Reversal by ethanol of the hypotensive effect of clonidine in conscious spontaneously hypertensive rats. Hypertension 1989;14:531-41.
12. Abdel-Rahman AA, Carroll RG, El-Mas MM. Role of the sympathetic nervous system in alcohol-guanabenz hemodynamic interaction. Can J Physiol Pharmacol 1992;70:1217-24.
13. Abdel-Rahman AA, Dar MS, Wooles WR. Effects of chronic ethanol administration on baroreceptor function and pressor and depressor responsiveness in rats. J Pharmacol Exp Ther 1985;232:194-201.
14. Chandler C, Ong BY, Sitar DS. Kinetic disposition of ethanol in the neonatal piglet and hemodynamic effects in the presence and absence of 4-methylpyrazole. Toxicol Appl Pharmacol 1989;99: 185-92.
15. El-Mas MM, Abdel-Rahman AA. Role of aortic baroreceptors in ethanol-induced impairment of baroreflex control of heart rate in conscious rats. J Pharmacol Exp Ther 1992;262:157-65.
16. Abdel-Rahman AA, Russ R, Strickland A, Wooles WR. Acute effects of ethanol on baroreceptor reflex control of heart rate and on pressor and depressor responsiveness in rats. Can J Physiol Pharmacol 1987;65:834-41.
17. Abdel-Rahman AA, Merrill RH, Wooles WR. Effect of acute ethanol administration on the baroreceptor reflex control of heart rate in normotensive human volunteers. Clin Sci 1987;72:113-22.
18. Ireland MA, Vandongen R, Davidson L, Beilin L, Rouse IL. Acute effects of moderate alcohol consumption on blood pressure and plasma catecholamines. Clin Sci 1984;66:643-8.
19. 2+ concentration in arterial and venous smooth muscle. Experientia 1979;35:639-40.
20. Nolan PL, Bentley GA. The effect of intracisternal administration of α-adrenoceptor agonists on the systemic blood pressure and its response to head-up tilting in anesthetized cats. Clin Exp Pharmacol Physiol 1978;5:429-38.
21. Abdel-Rahman AA. Aortic baroreceptors exert a tonically active restraining influence on centrally mediated depressor responses. J Cardiovasc Pharmacol 1992;19:233-45.
22. El-Mas MM, Carroll RG, Abdel-Rahman AA. Centrally mediated reduction in cardiac output elicits the enhanced hypotensive effect of clonidine in conscious aortic barodenervated rats. J Cardiovasc Pharmacol 1994;24:184-93.
23. Bernt E, Gutmann I. Ethanol: determination with alcohol dehydrogenase and NAD. In: Bergmeyer HU, ed. Methods of enzymatic analysis. 2nd ed, Vol 3. New York: Academic Press, 1974:1499-502.
24. Abdel-Rahman AA. Alcohol abolishes the hypotensive effect of clonidine in spontaneously hypertensive rats. Hypertension 1994;24:802-7.
25. Potter F, Beevers F. Pressor effect of alcohol in hypertension. Lancet 1984;1:119-22.
26. Gomez RE, Ernsberger P, Feinland G, Reis D. Rilmenidine lowers arterial pressure via imidazoline receptors in brainstem C1 area. Eur J Pharmacol 1991;195:181-91.
27. Punnen S, Urbanski R, Krieger A, Sapru HN. Ventrolateral medullary pressor area: site of hypotensive action of clonidine. Brain Res 1987;422:336-46.
28. Zhang X, Abdel-Rahman AA, Wooles WR. Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol. Hypertension 1989;14:282-92.
29. Zandberg P, Deong W. Hypotensive action of clonidine after adrenalectomy in the rat. J Pharm Pharmacol 1977;29:697-8.
30. Kubo T, Misu Y. Pharmacological characterization of the α-adrenoceptors responsible for a decrease of blood pressure in the nucleus tractus solitarii of the rat. Naunyn Schmiedebergs Arch Pharmacol 1981;317:120-5.
31. Head GA, Burke SL, Chan CKS. Central imidazoline receptors and centrally acting anti-hypertensive agents. Clin Exp Hypertens 1997;19:591-605.
32. Sinha N, Gurtu S, Sharma DK, Bhargava KP. An analysis of the α-adrenoceptor modulation of vasomotor tone at the level of lateral medullary pressor area (LMPA). Naunyn Schmiedebergs Arch Pharmacol 1985;330:163-8.
33. 1-Noradrenergic neurons tonically inhibit sympathoexcitatory neurons of the C1 area in rat brainstem. Brain Res 1986;377:127-46.
34. Chan CKS, Head GA. Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine. J Hypertens 1996;14:855-64.
35. 2-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol 1993;348:593-600.
36. 2-adrenoceptors in the cardiovascular effects of moxonidine. Eur J Pharmacol 1995;282:19-28.
37. Feldman J, Tibirica E, Bricca G, Dontenwill M, Belcourt A, Bousquet P. Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit. Br J Pharmacol 1990;100:600-4.
38. Badoer E, Head G, Korner PI. Effects of intracisternal and intravenous alpha-methyldopa and clonidine on haemodynamics and baroreceptor-heart rate reflex properties in conscious rabbits. J Cardiovasc Pharmacol 1983;5:760-7.
39. Child S, Kovick RB, Levisman A, Pearce ML. Cardiac effects of acute ethanol ingestion unmasked by autonomic blockade. Circulation 1979;59:120-5.
40. Ruffolo RR Jr, Stadel M, Hieble P. Alpha-adrenoceptors: recent developments. Med Res Rev 1994;14:229-70.
41. 2a-adrenergic receptor subtype. Science 1996;273:801-3.
42. Tibirica E, Feldman J, Mermet C. Gonon F, Bousquet P. An imidazoline-specific mechanism for the hypotensive effect of clonidine: a study with yohimbine and idazoxan. J Pharmacol Exp Ther 1991;256:606-13.
43. Mao L, Abdel-Rahman AA. Synergistic behavioral interaction between ethanol and clonidine in rats: role of alpha-2 adrenoceptors. J Pharmacol Exp Ther 1996;279:443-9.
44. Volicer L, Volicer B, Gravras H. The effect of alcohol intake on compliance with antihypertensive treatment In: Messiha FS, Tyner GS, eds. Alcoholism: a perspective. New York: PD Publishing, 1978:88-99.
45. Puddey IB, Beilin L, Vandongen R. Regular alcohol use raises blood pressure in treated hypertensive subjects: a randomized controlled trial. Lancet 1987;2:647-51.