In vitro positive selection and anergy induction of class II-restricted TCR transgenic thymocytes by a cortical thymic epithelial cell line

International Immunology

Volumn 10, Issue 9, 1998, Pages 1335-1346

  Nelson, Andrew J ^a   Clegg, Christopher H ^b   Farr, Andrew G ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

Cortical thymic epithelium; Positive selection; TCR

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN; CD8 ANTIGEN; CYTOCHROME C; GAMMA INTERFERON; HLA B7 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; EPITHELIUM CELL; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THYMOCYTE; THYMUS HYPERPLASIA; TRANSGENE; VIRUS ONCOGENE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CLONAL ANERGY; CYTOCHROME C GROUP; EPITHELIAL CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STROMAL CELLS; THYMUS GLAND;

EID: 0031683511     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.9.1335     Document Type: Article

References (55)

1. Jenkinson, E. J., Anderson, G. and Owen, J. J. T. 1992. Studies on T cell maturation on defined thymic stromal cell populations in vitro. J. Exp. Med. 176:845.
2. + thymic epithelial cells in vitro: costimulatory signals mediated by B7 are not involved. Dev. Immunol. 3:265.
3. - thymocytes in short-term thymic stromal cell culture. J. Exp. Med. 176:543.
4. Faas, S. J., Rothstein, J. L., Kreider, B. L., Rovera, G. and Knowles, B. B. 1993. Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells. Eur. J. Immunol. 23:1201.
5. Moll J., Eibel, H., Botteri, F., Sansig, G., Regnier, C. and van der Putten, H. 1992. Transgenes encoding mutant simian virus 40 large T antigens unmask phenotypic and functional constraints in thymic epithelial cells. Oncogens 7:2175.
6. Tanaka, Y., Mamalaki, C., Stockinger, B. and Kioussis, D. 1993. In vitro negative selection of alpha beta T cell receptor transgenic thymocytes by conditionally immortalized thymic cortal epithelial cell lines and dendritic cells. Eur. J. Immunol. 23:2614.
7. Vukmanovic, S., Gandea, A. G., Faas, S. J., Knowles, B. B. and Bevan, M. J. 1992. Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line. Nature 359:729.
8. Hugo, P., Kappler, J. W., McCormack, J. E. and Marrack, P. 1993. Fibroblasts can induce thymccyte positive selection in vivo. Proc. Natl Acad. Sci. USA 90:10335.
9. Tanaka, Y., Williams, O., Tarazona, R., Wack, A., Norton, T. and Kioussis D. 1997. In vitro positive selection of αβ TCR transgenic thymocyte by a conditionally immortalized cortical epithelial clone. Int. Immunol. 9:381.
10. Melero, I., Singhal, M. C., McGowan, P., Haugen, H. S., Blake, J., Hellstrom, K. E., Clegg, C. H. and Chen, L. 1997. Immunological ignorance to an E7-encoded cytolytic T lymphocyte epitope in transgenic mice expressing the E7-E6 oncogenes of human papillomavirus 16. J. Virol. 71:3998.
11. Dyson, N., Howley, P. M., Munger, K and Harlow, E. 1989. The papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934.
12. DeCaprio, J. A., Ludlow, J. W., Figge, J. Shew, J.-Y., Huang, C.-M., Lee. W.-H., Marsilio, E., Paucha, E. and Livingston, D. M. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275.
13. Werness, B. A., Levine, A. J. and Howley, P. M. 1990. Association of human papillomavirus type 16 and 18 E6 proteins with p53. Science 248:76.
14. Hawley-Nelson, P., Vousden, K. H., Hubbert., N. L., Lowy, D. R. and Schiller, J. T. 1989. HPV-16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J. 8:3905.
15. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341:746.
16. Kaye, J. and Ellenberger, D. L. 1992. Differentiation of an immature T cell line: a model of thymic positive selection. Cell 71:423.
17. Glimcher, L. H., Kruisbeek, A. M., Paul, W. E. and Green, I. 1983. Functional activity of a transformed thymic epithelial cell line. Scand. J. Immunol. 17:1.
18. Farr, A. G., Hosier, S., Braddy, S. C., Anderson, S. K., Eisenhardt, D. J., Yan, Z. J. and Robles, C. P. 1989. Medullary epithelial cell lines from murine thymus constitutively secrete IL-1 and hematopoietic growth factors and express class II antigens in response to recombinant interferon-gamma. Cell. Immunol. 119:427.
19. Farr, A., Nelson, A., Hosier, S. and Kim, A. 1993. A novel cytokine-responsive cell surface glycoprotein defines a subset of medullary thymic epithelium in situ. J. Immunol. 150:1160.
20. Razi-Wolf, Z., Freeman, G. J,. Galvin, F., Benacerraf, B., Nadler, L. and Reiser, H. 1992. Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc. Natl Acad. Sci. USA 89:4210.
21. Adkins, B., Tidmarsh, G. F. and Weissman, I. L. 1988. Normal thymic cortical epithelial cells developmentally regulate the expression of a B-lineage transformation-associated antigen. Immunogenetics 27:180.
22. Kraal, G., Breel, M., Janse, M. and Bruin, G. 1986 Langerhans cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody. J. Exp. Med. 163:981.
23. Staerz, U. D., Rammensee, H.-G., Benedetto, J. D. and Bevan, M. J. 1985. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor. J. Immunol. 134:3994.
24. Takei F. 1985. Inhibition of mixed lymphocyte response by activation antigen (MALA-2). J. Immunol. 134:1403.
25. + thymocytes. Nature 330:170.
26. Miyake, K., Medina, K., Ishihara, K., Kimoto, M., Auerbach, R. and Kincade, P. W. 1991. A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. J. Cell. Biol. 114:557.
27. Farr, A. G., Nelson, A., Truex, J. and Hosier, S. 1991. Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium. J. Histochem. Cytochem. 39:645.
28. Schmid, I., Krall, W. J., Uittenbogaart, C. H., Braun, J. and Giorgi, J. V. 1992. Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry. Cytometry 13:204.
29. Tough, D. F. and Sprent, J. 1994. Turnover of naïve and memory phenotype T cells. J. Exp. Med. 179:1127.
30. Hume, D. A., Robinson, A. P., MacPherson, G. G, and Gordon, S. 1983. The mononuclear phagocyte system of the mouse defined by immunohistochemcal localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. J. Exp. Med. 158:1522.
31. Metlay, J. P., Witmer-Pack, M. D., Agger, R., Crowley, M. T., Lawess, D. and Steinman, R. M. 1980. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171:1753.
32. Galy, A. H. and Spits, H. 1992. CD40 is functionally expressed on human thymic epithelial cells. J. Immunol. 149:775.
33. Dunn, R. J., Luedecker, C. J., Haugen, H. S., Clegg, C. H. and Farr, A. G. 1997. Thymic overexpression of CD40 ligand disrupts normal thymic epithelial organization. J. Histochem. Cytochem. 45:1.
34. Benoist, C. and Mathis, D. 1989. Positive selection of the T cell repertoire: where and when does it occur? Cell 58:1027.
35. Berg, L. J., Pullen, A. M., Fazekas de St Groth, B., Mathis, D., Benoist, C. and Davis, M. M. 1989. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58:1035.
36. Spain, L. M. and Berg, L. J. 1992 Developmental regulation of thymocyte susceptibility to deletion by 'self'-peptide. J. Exp. Med. 176:213.
37. + thymocytes bind to thymic epithelial cells. The binding is elicited by both CD2/LFA-3 and LFA-1/ICAM-1 interactions. Eur. J. Immunol. 19:1631.
38. Salomon, D. R., Crisa, L., Mojcik, C. F., Ishii, J. K., Klier, G. and Shevach, E. M. 1997. Vascular cell adhesion molecule-1 is expressed by cortical thymic epithelial cells and mediates thymocyte adhesion. Implications for the function of alpha 4 beta 1 (VLA4) integrin in T cell development. Blood 89:2461.
39. Regnier-Vigouroux, A., Blanc, D., Pont, S., Marchetto, S. and Pierres, M. 1986. Accessory molecules and T cell activation I. Antigen receptor avidity differentially influences T cell sensitivity to inhibition by monoclonal antibodies to LFA-1 and L3T4. Eur. J. Immunol. 16:1385.
40. Wang, R., Nelson, A., Kimachi, K., Gray, H. M. and Farr, A. G. 1988. The role of peptides in thymic positive selection of class II MHC-restricted T cells. Proc. Natl Acad. Sci. USA 95:3804.
41. Matechak, E. O., Killeen, N., Hedrick, S. M. and Fowlkes, B. J. 1996. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4:337.
42. hi thymocytes. J. Exp. Med. 181:1643.
43. Nakano, N., Rooke, R., Benoist, C. and Mathis, D. 1997. Positive selection of T cells induced by viral delivery of neopeptides to the thymus. Science 275:678.
44. Vasquez, N. J., Kaye, J. and Hedrick, S. M. 1992. In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175:1307.
45. + thymocytes. J. Immunol. 151:1868.
46. + thymocytes. Nature 333:742.
47. + thymocytes: a model based on T-cell receptor avidity. Immunol. Today 16:428.
48. Sebzda, E., Wallace, W. A., Mayer, J,. Yeung, R. S., Mak, T. W. and Ohashi, P. S. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263:1615.
49. Ashton-Rickardt, P. G., Bandeira, A,. Delaney, J. R., Van Kaer, L., Pircher, H. P., Zinkernagel, R. M. and Tonegawa, S. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651.
50. + T cells. Immunity 3:79.
51. Girao, C., Hu, Q., Sun, J. and Ashton-Rickardt, P. G. 1997. Limits to the differential avidity model of T cell selection in the thymus. J. Immunol. 59:4205.
52. Fischer, M., MacNeil, I., Suda, T., Cupp, J. E., Shortman, K. and Zlotnik, A. 1991. Cytokine production by mature and immature thymocytes. J. Immunol. 146:3452.
53. Dalton, D. K., Pitts-Meek, S., Keshav, S., Figari, I. S., Bradley, A. and Stewart, T. A. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259:1693.
54. Jenkinson, E. J., Franchi, L. L., Gingston, R. and Owen, J. J. 1982. Effects of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: application in the production of chimeric thymus rudiments. Eur. J. Immunol. 12:583.
55. Cibotti, R., Punt, J. A. Dash, K. S., Sharrow, S. O. and Singer, A. 1997. Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals. Immunity 6:245.