Inhibition of cytotoxic alloreactivity by human allogeneic mononuclear cells: Evidence for veto function of CD2+ cells

Immunology

Volumn 94, Issue 1, 1998, Pages 101-108

  Raddatz, G ^a   Deiwick, A ^a   Sato, T ^a   Schlitt, H J ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; CELL SURFACE MARKER; INDOMETACIN; INTERLEUKIN 2;

ALLOIMMUNITY; ANIMAL CELL; ARTICLE; BLOOD CELL; BONE MARROW CELL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; EFFECTOR CELL; HUMAN; HUMAN CELL; LYMPH NODE CELL; MIXED LEUKOCYTE CULTURE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; SHEEP ERYTHROCYTE;

ANTIGENS, CD2; BONE MARROW; CD8-POSITIVE T-LYMPHOCYTES; CELL CULTURE TECHNIQUES; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; LYMPHOCYTE CULTURE TEST, MIXED; PROSTAGLANDINS; TRANSPLANTATION IMMUNOLOGY;

EID: 0031681389     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00480.x     Document Type: Article

References (45)

1. THOMAS J.M., VERBANAC K.M., CARVER F.M. et al. (1994) Veto cells in transplantation tolerance. Clin Transplant 8, 195.
2. MILLER R.G. (1980) An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it. Nature 287, 544.
3. + T cells. J Exp Med 172, 719.
4. MARTIN D.R., SHENG-TANNER X. & MILLER R.G. (1992) Rapid and long-term changes to host cytotoxic T lymphocyte precursors reactive to donor antigens caused by intravenous injection of histoincompatible lymphocytes. Transplantation 54, 125.
5. + lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection. J Immunol 147, 713.
6. LE GROS G., BEN-SASSON S.Z., SEDER R., FINKELMAN F.D. & PAUL W.E. (1990) Generation of interleukin 4 (1L-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med 172, 921.
7. BAKIC ST., VUCKOVIC-DEKIC I.J., SUSNJAR S. & SPUZIC I. (1992) In vitro effect of indomethacin on mitogen-induced lymphoproliferative response in lung cancer patients. Neoplasma 39, 129.
8. ENDO F., SASAKI T., SEKIGUCCI Y. et al. (1981) The role of monocytes and prostaglandin E in the regulation of mitogen responses J Exp Med 133, 119.
9. SAFFRAN D.C. & SINGHAL S.K. (1991) Suppression of mixed lymphocyte reaction by murine bone marrow-derived suppressor factor-inhibition of proliferation due to a deficit in IL-2 production. Transplantation 52, 685.
10. CASSELL D. & FORMAN J. (1990) Regulation of the cytotoxic T lymphocyte response against Qa-1 alloantigens. J Immunol 144, 4075.
11. SCHWARTZ R.H. (1990) A cell culture model for T lymphocyte clonal anergy. Science 248, 1349.
12. ROSER B.J. (1989) Cellular mechanisms in neonatal and adult tolerance. Immunol Rev 107, 179.
13. + cytotoxic and suppressor T cell clones. J Immunol 144, 32.
14. FINK P.J., RAMMENSEE H.G. & BEVAN M.J. (1984) Cloned cytolytic T cells can suppress primary cytotoxic responses directed against them. J Immunol 133, 1775.
15. MILLER R.G., MURAOKA S., CLAESSON M.H., REIMANN J. & BENIVSTE P. (1988) The veto phenomenon in T-cell regulation. Ann NY Acad Sci 532, 170.
16. THOMAS J., CARVER F.M., CUNNINGHAM P.R.G., OLSON L.C. & THOMAS F.T. (1991) Kidney allograft tolerance in primates without chronic immunosuppression the role of veto cells. Transplantation 51, 198.
17. BURLINGHAM W.J., GRAILER A.P., FECHNER J.H. et al. (1995) Microchimerism linked to cytotoxic T lymphocyte functional unresponsiveness (clonal anergy) in a tolerant renal transplant recipient. Transplantation 59, 1147.
18. LAGOO-DEENADAYALAN S., LAGOO A.S., LEMONS J.A. et al. (1995) Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate Th1 and Th2 cytokine gene expression in the responder cell population. Transplant Immunol 3, 124.
19. MATHEW J.M., CARRENO M., FULLER L. et al. (1997) Modulatory effects of human donor bone marrow cells on allogeneic cellular immune responses. Transplantation 63, 686.
20. THOMAS J., CARVER F.M., KASTEN-JOLLY J. et al. (1994) Further studies of veto activity in rhesus monkey bone marrow in relation to allograft tolerance and chimerism. Transplantation 57, 101.
21. a expressing cells. Nature 339, 541.
22. DALLMAN M.J., SHIHO O., PAGE T.K., WOOD K.J. & MORRIS P.J. (1991) Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J Exp Med 173, 79.
23. BEVERLY B., KANG S.M., LEONARDO M.J. & SCHWARIZ R.H. (1992) Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int Immunol 4, 661.
24. HERBERMAN R.B. (1987) Lymphokine-activated killer cell activity. Immunol Today 8, 178.
25. FAST L.D. (1992) Generation and characterization of IL-2-activated veto cells. J Immunol 149, 1510.
26. + cells. J Immunol 145, 1646.
27. KAPLAN D.R., HAMBOR J.E. & TYKOCINSKI M.L. (1989) An immunoregulatory function for the CD8 molcule. Proc Natl Acad Sci USA 86, 8512.
28. SAMBHARA S.R. & MILLER R.G. (1991) Programmed cell death of T cells signaled by the T cell receptor and the γ3 domain of class I MHC. Science 252, 1424.
29. MILLER R.G., ZHANG L., TANNER Z.F.S., HAMMAD N. & RADVANYI L. (1993) The veto hypothesis and transplantation tolerance. Transplant Sci 3, 206.
30. THOMAS J., VERBANAC K.M., SMITH P.J. et al. (1995) The facilitating effect of one-DR antigen sharing in renal allograft tolerance induced by donor bone marrow in rhesus monkeys. Transplantation 59, 245.
31. UBERTI J., MARTHLOTTI F., CHOU T.H. & KAPLAN J. (1992) Human lymphokine activated (LAK) cells suppress generation of allospecific cytotoxic T cells: implications for use to prevent graft-vs.-host disease in allogeneic bone marrow transplantation. Blood 79, 261.
32. THOMSON A.W., LU L., MURASE N., DIEMETRIS A.J., RAO A.S. & STARZL T.E. (1995) Microchimerism, dendritic cell precursors and transplantation tolerance. Stem Cells Dayt 13, 622.
33. HOLDA J.H., MAIER T. & CLAMAN H.N. (1985) Murine graft-vs.-host disease across minor barriers: immunsuppressive aspects of natural suppressor cells, Immunol Rev 88, 87.
34. VANVLASSELAER P., NIKI T. & STROBER S. (1991) Identification of a factor (s) from cloned murine natural suppressor cells that inhibits IL-2 secretion during antigen-driven T-cell activation. Cell Immunol 138, 326.
35. YAMAMOTO H., HIRAYAMA M., GENYEA C. & KAPLAN J. (1994) TCF-beta mediates natural suppressor activity of IL-2 activated lymphocytes. J Immunol 152, 3842.
36. CASSELL D. & FORMAN J. (1991) Two roles for CD4 cells in the control of the generation of cytotoxic T lymphocytes. J Immunol 146, 3.
37. + T lymphocytes by antigen presentation on resting B cells a hypothesis. Bone Marrow Transplant 7, 26.
38. TAKAHASHI T. & MAKI T. (1991) Prolongation of mouse skin allograft survival by cloned veto suppressor cells. Transplant Proc 23, 192.
39. KAUFMANN C.H., COLSON Y.L., WREN S.M., WATKINS S., SIMMONS R.L. & ILDSTAD S.T. (1994) Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 84, 2436.
40. CHAN A.S. & MILLER R.G. (1997) Activated human T lymphocytes specifically suppress CTL responses against their HLA antigens. 4th International Conference on Tolerance Induction, p. 19. Breckenridge, CO, USA.
41. SCHLITT H.J., RADDATZ G., STEINHOFF G., WONIGEIT K. & PICHLMAYR R. (1993) Passenger lymphocytes in human liver allografts and their potential role after transplantation. Transplantation 56, 951.
42. SCHLITT H.J., KANEHIRO H., RADDATZ G. et al. (1993) Persistence of donor lymphocytes in liver allograft recipients. Transplantation 56, 1001.
43. SUN J., MCCAUGHAN G.W., GALLAGHER N.D., SHEIL A.G.R. & BISHOP G.A. (1995) Deletion of spontaneous rat liver allograft acceptance by donor irradiation. Transplantation 60, 233.
44. QI Y., BERG R., SINGLETON M.A., DEBRICK J.E. & STAERZ D.U. (1996) Hybrid antibody mediated veto of cytotoxic T lymphocyte responses. J Exp Med 183, 1973.
45. MARTIN P.J. (1996) Prevention of allogeneic marrow graft rejection by donor T cells that do not recognize recipient alloantigens: potential role of a veto mechanisms. Blood 88, 962.