Low-level m-xylene inhalation alters pulmonary and hepatic cytochrome P-450 activity in the rat

Journal of Toxicology and Environmental Health - Part A

Volumn 47, Issue 2, 1996, Pages 135-144

  Foy, Jeffrey W D ^a   Silverman, Diane M ^a   Schatz, Robert A ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; META XYLENE; MIXED FUNCTION OXIDASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; INHALATION; LIVER; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, INHALATION; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; ISOENZYMES; LIVER; LUNG; MALE; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; XYLENES;

ANIMALIA;

EID: 0030046505     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/009841096161843     Document Type: Article

References (43)

1. Agency for Toxic Substances and Disease Regulation. 1993a. Toxicologic Profile for Xylenes. U.S. Department of Health and Human Services, Public Health Services, October.
2. Agency for Toxic Substances and Disease Regulation. 1993b. Toxicologic Profile for Jet Fuels JP-4 and JP-7. U.S. Department of Health and Human Services, Public Health Services, May.
3. Beland, F. A., Beranek, D. T., Dooley, K. L., Heflich, R. H., and Kadlubar, F. F. 1983. Arylamine-DNA adducts in vitro and in vivo: Their role in bacterial mutagenesis and urinary bladder carcinogenesis. Environ. Health Perspect. 49:125-134.
4. Belanger, P. M., Grech-Belanger, O., and Blouin, M. 1981. Colorimetric determination of N-hydroxylated metabolites in microsomal studies. Anal. Biochem. 118:47-52.
5. Bond, J. 1993. Metabolism of xenobiotics by the respiratory tract. In Toxicology of the Lung, 2nd ed., eds. D. P. Gardner, J. D. Crapo, and R. O. McClellan, pp. 187-216. New York: Raven Press.
6. Boyd, M. A., Burka, L. T., Benjamen, J. W., and Sasame, H. A. 1978. In vitro studies on the metabolic activation of the pulmonary toxin, 4-ipomeanol, by rat lung and liver microsomes. J. Pharmacol. Exp. Ther. 207:677-686.
7. Burke, M. D., Thombson, S., Elcombe, C. R., Halpert, J., Haaparenta, T., and Mayer, R. T. 1985. Ethoxy-, pentoxy-, and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P450. Biochem. Pharmacol. 34:3337-3345.
8. Carlson, G. P. 1990. Induction of N-nitrosodimethylamine metabolism in rat liver and lung by ethanol. Cancer Lett. 54:153-156.
9. Day, B. J., and Carlson, G. P. 1992. Effect of p-xylene metabolites, p-methylbenzyl alcohol and 2,5-dimethylphenol, on rat hepatic and pulmonary microsomal metabolism. Res. Commun. Chem. Pathol. Pharmacol. 76:117-120.
10. Elovaara, E. 1982. Dose-related effects of m-xylene inhalation on the xenobiotic metabolism of the rat. Xenobiotica 12:345-352.
11. Elovaara, E., Collan, Y., Pfäffli, P., and Vaino, H. 1980. The combined toxicity of technical grade xylene and ethanol in the rat. Xenobiotica 10:435-445.
12. Elovaara, E., Ziiting, A., Nickels, J., and Aitio. 1987. m-Xylene inhalation destroys cytochrome P-450 in rat lung at low exposure. Arch. Toxicol. 61:21-26.
13. Guengerich, F. P., Kim, D.-H., and Masahiko, I. 1991. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4:168-179.
14. Howd, R. A., Bingham, E. R., Steeger, T. M., Rebert, C. S., and Pryor, G. T. 1982. Relation between schedules of exposure to hexane and plasma levels of 2,5-hexanedione. Neurobehav. Toxicol. Teratol. 4:87.
15. Ioannides, C., and Park, D. V. 1987. The cytochromes P-448 - A unique family of enzymes involved in chemical toxicity and carcinogenesis. Biochem. Pharmacol. 36:4197-4208.
16. Kaneko, T., Pei-Yu, W., Hiroshi, T., and Sato, A. 1995. m-xylene toxicokinetics in phenobarital-treated rats: Comparison among inhalation exposure, oral administration, and intraperitoneal administration. Toxicol. Appl. Pharmacol. 131:13-20.
17. Koop, D. R., and Tierney, D. J. 1990. Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1 . Bioessays 12:429-435.
18. Lebel, C. P., and Schatz, R. A. 1988. Toluene-induced alterations in rat synaptosomal membrane composition and function. J. Biochem. Toxicol. 3:279-293.
19. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 198:265-275.
20. Nakajima, T., Wang, R.-S., Elovaara, E., Park, S. S., Gelboin, H. V., Hietanen, E., and Vainio, H. 1991. Monoclonal antibody-directed characterization of cytochrome P450 isozymes responsible for toluene metabolism in rat liver. Biochem. Pharmacol. 41:395-404.
21. Nash, T. 1953. The colorimetric measurement of formaldehyde by means of the Hantzsch reaction. Biochem. J. 55:416-421.
22. Nebert, D. W., and Gelboin, H. V. 1968. Substrate induced microsomal AHH in mammalian cell culture. I. Assays and properties of induced enzymes. J. Biol. Chem. 243:6242-6249.
23. Nebert, D. W., Robinson, A. N., Kumaki, K., and Poland, A. P. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J. Cell. Physiol. 85:393-414.
24. Nerurkar, P. V., Park, S. S., Thomas, P. E., Nims, R. W., and Lubet, R. A. 1993. Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P450 1A2 and 2B, respectively, in the rat and mouse. Biochem. Pharmacol. 46:933-945.
25. Oguri, K., and Yamada, H. 1994. Regiochemistry of cytochrome P450 isozymes. Annu. Rev. Pharmacol. Toxicol. 34:251-279.
26. Pahlman, R., and Pelkonen, O. 1987. Mutagenicity studies of different polycyclic aromatic hydrocarbons: the significance of enzymatic factors and molecular structure. Carcinogenesis 8:773-778.
27. Park, S.-H., and Schatz, R. A. 1994. Effect of o-xylene inhalation on in vitro BaP metabolism and BPDE-DNA adduct formation in rat lung and liver. Toxicologist 14:333 (abstr.).
28. Park, S.-H., Silverman, D. M., and Schatz, R. A. 1993. Effect of low level (300 ppm) 1 day inhalation of o-xylene on in vitro BaP metabolism and BaP-DNA adduct formation in rat lung and liver. Toxicologist 13:366 (abstr.).
29. Park, S.-H., AuCoin, T. A., Silverman, D. M., and Schatz, R. A. 1994. Time-dependent effects of o-xylene on rat lung and liver microsomal membrane structure and function. J. Toxicol. Environ. Health 43:469-481.
30. Patel, J. M., Harper, C., and Drew, R. T. 1978. The biotransformation of p-xylene to a toxic aldehyde. Drug Metab. Dispos. 6:368-374.
31. Patel, J. M., Wolf, C. R., and Philpot, R. M. 1979. Interaction of 4-methylbenzalaldehyde with rabbit pulmonary cytochrome P-450 in the intact animal, microsomes, and purified systems. Destructive and protective reactions. Biochem. Pharmacol. 28:2031-2036.
32. Philpot, R. M., and Smith, B. R. 1984. Role of cytochrome P-450 and related enzymes in the pulmonary metabolism of xenobiotics. Environ. Health Perspect. 55:359-357.
33. Sesardic, D., Cole, K. J., Edwards, R. J., Davies, D. S., Thomas, P. E., Levin, W., and Boobis, A. R. 1989. The inducibility and catalytic activity of cytochromes P450c (P4501A1) and P450d (1A2) in rat tissues. Biochem. Pharmacol. 39:499-506.
34. Shimada, T., Yamazaki, H., Mimura, M., and Guengerich, P. 1992. Rat pulmonary microsomal P-450 enzymes involved in the activation of procarcinogens. Mutat. Res. 284:223-241.
35. Silverman, D. M., and Schatz, R. A. 1990. Pulmonary microsomal alterations following short-term low level inhalation of p-xylene in rats. Toxicology 65:271-281.
36. Simmons, D. L., and Kasper, C. A. 1989. Quantitation of mRNAs for the mixed-function oxidase system in rat liver and extrahepatic tissues during development. Arch. Biochem. Biophys. 271:10-20.
37. Spink, D. C., Eugster, H.-P., Lincoln, D. W., II, Schuetz, J. D., Schuetz, E. G., Johnson, J. A., Kaminsky, E. S., and Gierthy, J. F. 1992. 17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: A comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch. Biochem. Biophys. 293:342-348.
38. Stickney, J. A., Roberts, A. E., Silverman, D. M., and Schatz, R. A. 1989. The effect of m-xylene on rat lung benzo(a)pyrene metabolism and microsomal membrane lipids: Comparison with p-xylene. Toxicology 58:155-165.
39. Stickney, J. A., Silverman, D. M., and Schatz, R. A. 1990. Role of isozyme-specific inhibition of cytochrome P450 IIB1 activity in m-xylene-induced alterations in rat pulmonary benzo(a)pyrene metabolism. Xenobiotica 21:641-649.
40. Stickney, J. A., Silverman, D. M., and Schatz, R. A. 1991. Inhibition of cytochrome P450 isozymes by m-xylene and its metabolite m-tolualdehyde in rat lung microsomes. Toxicologist 11:317 (abstr.).
41. Tassaneeyakul, W., Birkett, D. J., Veronese, M. E., McManus, M. E., Tukey, R. H., Quatrochi, L. C., Gelboin, H. V., and Miners, J. O. 1993. Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. J. Pharmacol. Exp. Ther. 265:401-407.
42. Vanderslice, R. R., Domin, B. A., Carver, G. T., and Philpot, R. M. 1987. Species-dependent expression and induction of homologues of rabbit cytochrome P-450 isozyme 5 in liver and lung. Mol. Pharmacol. 31:320-325.
43. Verschoyle, R. D., Dinsdale, D., and Wolf, C. R. 1993. Inhibition and induction of cytochrome P450 isoenzymes in rat lung. J. Pharmacol. Exp. Ther. 265:386-391.