Kinetics of intraocular cytokines in the suppression of experimental autoimmune uveoretinitis by type I IFN

International Immunology

Volumn 10, Issue 12, 1998, Pages 1917-1922

  Okada, Annabelle A ^a,b   Keino, Hiroshi ^a   Suzuki, Jun ^a   Sakai, Jun Ichi ^a   Usui, Masahiko ^a   Mizuguchi, Junichiro ^b  

^a TOKYO MEDICAL UNIVERSITY HOSPITAL   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

IFN ; IFN ; IL; Interphotoreceptor retinoid binding protein

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DRUG MECHANISM; DRUG TISSUE LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; INFLAMMATION; INTRAMUSCULAR DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; UVEORETINITIS;

EID: 0031677861     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.12.1917     Document Type: Article

References (36)

1. Baron, S., Tyring, S. K., Fleischmann, W. R., Coppenhaver, D. H., Niesel, D. W., Klimpel, G. R., Stanton, G. J. and Hughes, T. K. 1991. The interferons: mechanisms of action and clinical applications. J. Am. Med. Ass. 266:1375.
2. Borden, E. C. 1992. Interferons - expanding therapeutic roles. N. Engl. J. Med. 326:1198.
3. Weinstock-Guttman, B., Ransohoff, R. M., Kinkel, R. P. and Rudick, R. A. 1995. The interferons: biological effects, mechanisms of action, and use in multiple sclerosis. Ann. Neurol. 37:7.
4. Arnason, B. G. W. 1996. Interferon beta in multiple sclerosis. Clin, Immunol. Immunopathol. 81:1.
5. Tsambaos, D., Eichelberg, D. and Goos, M. 1986. Behçet's syndrome: treatment with recombinant leukocyte alpha-interferon. Arch. Dermatol. Res. 278:335.
6. Durand, J. M., Kaplanski, G., Telle, H., Soubeyrand, J. and Paulo, F. 1993. Beneficial effects of interferon-α2b in Behçet's disease. Arthrits Rheum. 36:1025.
7. Feron, E. J., Rothova, A., van Hagen, P. M., Baarsma, G. S. and Suttorp-Schulten, M. S. A. 1994. Interferon α2b for refractory ocular Behçet's disease. Lancet 343:1428.
8. Kötier, I., Dürk, H., Eckstein, A., Zierhut, M., Fierlbeck, G. and Saal, J. G. 1996. Erosive arthritis and posterior uveitis in Behçet's disease: treatment with interferon a and interferon γ. Clin. Exp. Rheumatol. 14:313.
9. Költer, I., Eckstein, A. K., Stübiger, N. and Zierhut, M. 1998. Treatment of ocular symptoms of Behçet's disease with interferon α: a pilot study. Br. J. Ophthalmol. 82:488.
10. Gery, I., Wiggert, B., Redmond, T., Kuwabara, T., Crawford, M. A., vistica, B. P. and Chader, G. J. 1986. Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein. Invest. Ophthalmol. Vis. Sci. 27:1296.
11. Charteris, D. G. and Lightman, S. L. 1992. Interferon-gamma (IFN-γ) production in vivo in experimental autoimmune uveoretinitis. Immunology 75:463.
12. Barton, K., Lightman, S. 1994. T lymphocyte effector mechanisms in the retina in posterior uveitis. Eye 8:60.
13. h1 response. J. Immunol. 157:2668
14. Caspi, R. R., Sun, B., Agarwal, R. K., Silver, P. B., Rizzo, L. V., Chan, C. C., Wiggert, B. and Wilder, R. L. 1997. T cell mechanisms in experimental autoimmune uveoretinitis: susceptibility is a function of the cytokine response profile. Eye 11:209.
15. Keino, H., Okada, A. A., Fukai, T., Sakai, J., Usui, M. and Ishii, K. 1998. Systemic administration of type I interferon suppresses the onset of IRBP-induced experimental autoimmune uveoretinitis in rats. In Ohno, S., Aoki, K., Usui, M. and Uchio, E., eds, Uveitis Today, p. 15. Elsevier Science, Amsterdam.
16. Okada, A. A., Keino, H., Fukai, T., Sakai, J., Usui, M. and Mizuguchi, J. 1998. Effect of type I on experimental autoimmune uveoretinitis. Ocular Inflamm. Immunol., in press.
17. Fukuda, S., Fujii, M., Koide, K., Takimoto, A., Yamamoto, S., Aga, M., Goto, K. and Kurimoto, M. 1992. Large scale production and purification of natural murine interferon-α/β. Kagaku to Kogyo 66:404.
18. van der Meide, P. H., Dijkema, R., Caspers, M., Vijverberg, K. and Schellekens, H. 1986. Cloning, expression, and purification of rat IFN-α1. Methods Enzymol. 119(C): 441.
19. Redmond, T. M., Wiggert, B., Robey, F. A., Nguyen, N. Y., Lewis, M. S., Lee, L and Chader, G. J. 1985. Isolation and characterization of monkey interphotoreceptor retinoid-binding protein, a unique extracellular matrix component of the retina. Biochemistry 24:787
20. Okada, A. A., Sakai, J., Usui, M, and Mizuguchi, J. 1998. Intraocular cytokine quantification of experimental autoimmune uveoretinitis in rats. Ocular Inflamm. Immunol 6:1.
21. Mosmann, T. R. and Coffman, R. L. 1989. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv. Immunol. 46:111.
22. Barton, K., McLauchlan, M. T., Calder, V. L. and Lightman, S. 1995 The kinetics of cytokine mRNA expression in the retina during experimental autoimmune uveoretinitis. Cell, Immunol. 164:133.
23. H1-dependent autoimmune disease. Eur J. Immunol. 23:3096.
24. Narula, S. K., Cutler, D. and Grint, P. 1998. Immunomodulation of Crohn's disease by interleukin-10. In Therapeutic Strategies for Modulating the Inflammatory Diseases, p. 57. Birkhäuser, Basel.
25. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275.
26. Rosenbaum, J. T. and Angell, E. 1995. Paradoxical effects of IL10 in endotoxin-induced uveitis. J. Immunol. 155:4090.
27. Leotard, B., Bidet, S., de Kozak, Y. and Bellon, B. 1998. IL-10 fails to abrogate experimental autoimmune uveoretinitis (EAU). Ocular Immunol Inflamm. 6:S46.
28. Caspi, R. R., Chan C.-C., Grubbs, B. G., Silver, P. B., Wiggert, B., Parsa, C. F., Bahmanyar, S., Billiau, A. and Heremans, H. 1994. Endogenous systemic IFN-γ has a protective role against ocular autoimmunity in mice. J. Immunol. 152:890.
29. Hamel, C. P., Detrick, B. and Hooks, J. J. 1990. Evaluation of la expression in rat ocular tissues following inoculation with interferon-garnma. Exp. Eye Res. 40:173.
30. Lee, S. F. and Pepose, J. S. 1990. Cellular immune response to la induction by intraocular gamma-interferon. Ophthalm. Res. 22:310.
31. + T cell lines. J. Exp. Med. 185:1769
32. Brown, M. A. and Hural, J. 1997. Functions of IL-4 and control of its expression. Crit. Rev. Immunol. 17:1.
33. Mochizuki, M., Kuwabara, T., Chan, C. C., Nussenblatt, R. B., Metcalfe, D. D. and Geri, I. 1984. An association between susceptibility to experimental autoimmune uveitis and choroidal mast cell numbers. J. Immunol. 133:1699
34. Noronha, A., Toscas, A. and Jensen, M A 1993. Interferon beta decreases T cell activation and Interferon gamma production in multiple sclerosis. J. Neuroimmunol, 46:145.
35. Porrini, A. M., Gambi, D. and Reder, A. T. 1995. Interferon effects on interleukin-10 secretion: mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients. J. Neuroimmunol. 61:27.
36. Rudick, R. A., Ransohoff, R. M., Peppler, R., Medendorp, S. V., Lehmann, P. and Alam, J. 1996. Interferon beta induces interleukin-10 expression: relevance to multiple sclerosis. Ann. Neurol. 40:618.