CD3+CD8+ cell levels as predictors of transmission in human immunodeficiency virus-infected couples: A report from the heterosexual HIV transmission study

International Journal of Infectious Diseases

Volumn 2, Issue 4, 1998, Pages 186-192

  Denny, Thomas N ^a,b   Skurnick, Joan H ^a   Palumbo, Paul ^b   Perez, George ^c   Monel, Raymond ^b   Stephens, Richard ^b   Kennedy, Cheryl A ^a   Louria, Donald B ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UMDNJ New Jersey Medical School   (United States)

^c ST MICHAEL S MEDICAL CENTER   (United States)

Author keywords

CD3+CD8+ cells; Concordant; Discordant; HIV positive

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN;

ADULT; AGED; ARTICLE; FEMALE; HETEROSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PREDICTION; RISK FACTOR; SEROCONVERSION; SEXUAL INTERCOURSE; SEXUAL TRANSMISSION; VIRUS TRANSMISSION;

EID: 0031668749     PISSN: 12019712     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1201-9712(98)90050-9     Document Type: Article

References (27)

1. DeVincenzi I, for the European Study Group on Heterosexual Transmission of HIV. A longitudinal study of human immunodeficiency virus transmission by heterosexual partners. N Engl J Med 1994; 331:341-346.
2. Lawrence DN, Jason JM, Holman RC, Heine P, Evatt BL, and the Hemophilia Study Group. Sex practice correlates of human immunodeficiency virus transmission and acquired immunodeficiency syndrome incidence in heterosexual partners and offspring of U.S. hemophilic men. Am J Hematol 1989; 30:68-76.
3. Banks SE, Brown LS, Ajuluchukwu D. Sexual behaviors and HIV infection in intravenous drug users in New York City. J Addict Dis 1991; 10:15-23.
4. Kassler WJ, Zenilman JM, Erickson B, Fox R, Peterman TA, Hook EW III. Seroconversion in patients attending sexually transmitted disease clinics. AIDS 1994; 8:351-355.
5. Booth RE, Watters JK, Chitwood DD. HIV risk-related sex behaviors among injection drug users, crack smokers, and injection drug users who smoke crack. Am J Public Health 1993; 83 1144-1148.
6. Nicolosi A, Musicco M, Saracco A, Lazzarin A, for the Italian Study Group on HIV Heterosexual Transmission. Risk factors for woman-to-man sexual transmission of the human immunodeficiency virus. J AIDS 1994; 7:296-300.
7. Mastro JD. Probability of female-to-male transmission of HIV-1 in Thailand. Lancet 1994; 343:204-207.
8. Beretta A, Weiss SH, Rappocciolo G, et al. Seronegative intravenous drug users at risk for HIV exposure exhibit antibodies to HLA class I antigens and T cells specific for HIV envelope. J Infect Dis 1996; 173:472-476.
9. Dragic T, Litwin V, Allaway G, et al. HTV-1 entry into CD4 cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996; 381:667-673.
10. Padian NS, Shiboski SC, Jewell NP. The effect of number of exposures on the risk of heterosexual HIV transmission. J Infect Dis 1990; 161:883-887.
11. Skurnick JH, Kennedy CA, Perez G, et al. Behavioral and psychosocial risk factors for HIV-1 transmission in heterosexual couples. 1998 (Submitted).
12. AIDS Clinical Trial Group. Virology Manual for HIV Laboratories: Division of AIDS, National Institutes of Allergy and Infectious Diseases, Bethesda, MD, ACTG Virology Laboratory, 1994.
13. Fiscus SA, DeGruttola V, Gupta P, et al. Human immunodeficiency virus type 1 quantitative cell microculture as a measure of antiviral efficacy in a multicenter clinical trial. J Infect Dis 1995; 171:305-311.
14. Sarngadharan MG. Biochemical and immunological analysis of human immunodeficiency virus gag gene products p17 and p24. J Virol 1988; 62:795-801.
15. Nair BC, Ford G, Kalyanaraman VS, Zafari M, Fang C, Sarngadharan MG. Enzyme immunoassay using native envelope glycoprotein (gp160) for detection of human immunodeficiency virus type 1 antibodies. J Clin Microbiol 1994; 32: 1449-1456.
16. Calvelli T, Denny TN, Paxton H, Gelman R, Kagan J. Guideline for flow cytometric immunophenotyping: a report from the National Institute of Allergy and Infectious Diseases, Division of AIDS. Cytometry 1993; 14:702-715.
17. Richard B, Darlington. Regression and linear models. New York: McGraw-Hill, 1990:154-155.
18. Walker CA, Moody DJ, Stites DJ, Levy JA. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986; 234:1563-1566.
19. Mackewicz CE, Barker E, Levy J. Role of β-chemokines in suppressing HIV replication. Science 1996; 374:1393-1395.
20. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ cells. Science 1995; 270:1811-1815.
21. McKenzie SW, Dallalio G, North M, Frame P, Means RT Jr. Serum chemokine levels in patients with non-progressing HIV infection. AIDS 1996; 10:F29-F33.
22. Pantaleo G, Demarst JF, Schacker T, et al. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci USA 1997; 94:254-285.
23. Rowland-Jones S, Sutton J, Ariyoshi K, et al. HIV-specific cytotoxic T cells in HIV-exposed but uninfected Gambian women. Nat Med 1995; 1:59-64.
24. Rubbert A, Weissman D, Combadiere C, et al. Multifactorial nature of non-cytotoxic CD8+ T-cell mediated suppression of HIV replication: ß-chemokine dependent and independent effects. AIDS Res Hum Retroviruses 1997; 13:63-70.
25. Mackewicz CE, Yang LC, Lifson JD, Levy JA. Non-cytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection. Lancet 1994; 344.1671-1673.
26. Sperling RS, Shapiro DE, Coombs RW, et al. Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. N Engl J Med 1996; 335:1621-1624.
27. Rohowsky-Kochan C, Molinaro D, Skurnick J, Louria D. HLA antigens associated with susceptibility/resistance to HIV-1 infection. 1998 (Submitted).