Occupation of the cytochrome P450 substrate pocket by diverse compounds at general anesthesia concentrations

European Journal of Pharmacology

Volumn 358, Issue 2, 1998, Pages 177-185

  LaBella, Frank S ^a   Stein, Douglas ^a   Queen, Gary ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Absorbance difference spectrum; Anesthesia, general; Cytochrome P450; Heme enzyme

Indexed keywords

ALCOHOL; ANDROSTENEDIONE; ANESTHETIC AGENT; BUTANOL; CHLOROFORM; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; ETHER; HALOTHANE; HEME; HEXANOL; ISOFLURANE; METHANOL; NITROUS OXIDE; OCTANOL; PENTANOL; PENTOBARBITAL; PHENOBARBITAL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DISSOLUTION; ENZYME SUBSTRATE COMPLEX; GENERAL ANESTHESIA; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT;

ANESTHETICS, GENERAL; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; HEMEPROTEINS; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031667110     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00596-2     Document Type: Article

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