A general classification of U-shaped dose-response relationships in toxicology and their mechanistic foundations

Human and Experimental Toxicology

Volumn 17, Issue 7, 1998, Pages 353-364

  Calabrese, Edward J ^a   Baldwin, Linda A ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Hormesis; Low dose; Paradoxical effects; Risk assessment; U shaped

Indexed keywords

DATA BASE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; HOMEOSTASIS; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; STIMULATION; TOXICOLOGY;

EID: 0031665022     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719801700701     Document Type: Review

References (90)

1. Calabrese EJ, Baldwin LA. The dose determines the stimulation (and poison): development of a chemical hormesis database. Int J Toxicol 1997; 16: 545-559.
2. Trevan JW. The error of determination of toxicity. Proc Roy Soc Lond (Biol) 1927; 101: 483-514.
3. Bliss CI. The calculation of the dosage-mortality curve. Ann of Appl Biol 1935; 22: 134-167.
4. Bliss CI. The comparision of dosage-mortality data. Ann of Appl Biol 1935a; 22: 307-333.
5. Gaddum JH. Lognormal distributions. Nature 1945; 156: 463-466.
6. Gaddum JH. Bioassays and mathematics. Pharmacol Rev 1953; 5: 87-134.
7. Davis JM, Svendsgaard DJ. U-shaped dose-response curves: Their occurrence and implications for risk assessment. J Toxicol Environ Health 1990; 30: 71-83.
8. Calabrese EJ, McCarthy M and Kenyon E. The occurrence of chemical hormesis. Health Physics 1987; 57: 531-541.
9. Calabrese EJ. Expanding the reference dose concept to incorporate and optimize beneficial effects while preventing toxic responses from nonessential toxicants. Reg Toxicol Pharmacol 1996; 24: S68-S75.
10. Calabrese EJ, Baldwin LA. Historical foundations of hormesis. Toxicol Sci 1998; Submitted.
11. Calabrese EJ, Baldwin LA. The marginalization of hormesis. Toxicol Sci 1998a; Submitted.
12. Calabrese EJ. (ed). 1992. Biological Effects of Low Level Exposures to Chemicals and Radiation. CRC Press. Boca Raton, FL. pp. 155.
13. Calabrese EJ. (ed). 1994. Biological Effects of Low Level Exposures - Dose-Response Relationships. CRC Press, Boca Raton. FL. pp. 302.
14. Calabrese EJ. (ed.). Proceedings of the Third BELLE Conference on Toxicological Defense Mechanisms and the Shape of the Dose-Response Relationship. Environ Health Persp 1998; 106 (Suppl. 1): 275-394.
15. Sugahara T, Sagan LA, Aoyama T. (eds). 1995; Low-Dose Irradiation and Biological Defence Mechanisms. Elsevier Science Publishers, Amsterdam.
16. Liu S-Z. (ed). 1994. Proceedings of the International Symposium on Biological Effects of Low Level Exposures to Radiation and Related Agents. Changchum, China. Princeton Scientific Publishers. Princeton, NJ.
17. Calabrese EJ, Baldwin LA. A quantitatively-based methodology for the evaluation of chemical hormesis. Hum Ecol Risk Assess 1997; 3: 545-554.
18. Luckey TD. 1980. Hormesis with Ionizing Radiation. CRC Press, Boca Raton. pp. 222.
19. Stebbing ARD. Hormesis - The stimulation of growth by low levels of inhibitors. Sci Total Environ 1982; 22: 213-234.
20. Vichi P, Tritton TR. Stimulation of growth in human and murine cells by adriamycin. Cancer Res 1989; 49: 2679-2682.
21. Stebbing ARD. A theory for growth hormesis. BELLE Newsletter 1997; 6(2): 1-11.
22. Calabrese EJ. Evidence that hormesis represents an 'overcompensation' response to a disruption in homeostasis. Ecotoxical Environ Safety 1998; Submitted.
23. Townsend CO. The correlation of growth under the influence of injuries. Ann Bot 1897; 11: 509-532.
24. Branham SE. The effects of certain chemical compounds upon the course of gas production by baker's yeast. J Bacterial 1929; 18: 247.
25. Colley AW. Stimulation phenomena in the growth of bacteria as determined by nephelometry. Amer J Bot 1931; 18; 266-287.
26. Smith EC. Effects of ultra-violet radiation and temperature on Fursarium. II. Stimulation. Bull Torrey Bot Club 1935; 62: 151-164.
27. Calabrese EJ, Howe KJ. The effects of phosfon on the growth of Mentha piperita L. Physiol Plantarum 1976; 37: 163-165.
28. Folker-Hansen P, Krogh PH, Holmstrup M. Effect of dimethoate on body growth of representatives of the soil living mesofauna. Ecotoxicol Environ Safety 1996; 33: 207-216.
29. 2S fumigation on crop and forest plants. Environ Sci Technol 1978; 12: 550-553.
30. McGee BL, Schlekat CE, Reinharz E. Assessing sublethal levels of sediment contamination using the estuarine amphipod Leptocheirus plumulosus. Environ Toxicol Chem 1993; 12: 577-587.
31. Jenkins KD, Sanders BM. Relationships between free cadmium ion activity in seawater, cadmium accumulation and subcellular distribution, and growth in polychaetes. Environ Health Perspect 1986; 65: 205-210.
32. Stebbing ARD. The kinetics of growth control in a colonial hydroid. J Mar Biol Assoc UK 1981; 61: 35-63.
33. Harden A. 1911; Alcoholic Fermentation. Longmans, Green and Co., London, pp. 128.
34. Simon EW. The action of nitrophenols on respiration and on glucose assimilation in yeast. J Exp Bot 1953; 4: 377-392.
35. Takahashi K et al. Structural requirement for the induction of the adaptive response in Escherichia coli among N-(substituted)-N-nitrosources. Mut Res 1988; 202: 193-201.
36. Kramer KK, Zoelle JT, Klaasen CD. Induction of metallothionein mRNA and protein in primary murine neuron cultures. Toxicol Appl Pharmacol 1996; 141: 1-7.
37. Nukada T, Haga T, Ichiyama A. Muscarine receptors in procine caudate nucleus. Mol Pharmacol 1983; 24: 366-373.
38. Barton LV, MacNab J. Effect of antibiotics on plant growth. Contrib Boyce Thompson Inst 1954; 17: 419-434.
39. Rubin H. Nonspecific nature of the stimulus to DNA synthesis in cultures of chick embryo cells. PNAS USA 1975; 72: 1676-1680.
40. Jung G, Hennings G, Pfeifer M, Bessler WG. Interaction of metal-complexing compounds with lymphocytes and lymphoid cell lines. Mol Pharmacol 1983; 23: 698-702.
41. Bengtsson G, Gunnarsson T, Rundgren S. Influence of metals on reproduction, mortality and population growth in Onychiurus armatus (Collembola). J Appl Ecol 1985; 22: 967-978.
42. Clarkson DT. Aluminium tolerance in species within the genus Agrostis. J Ecol 1966; 54: 167-178.
43. Grime JP, Hodgson JG. 1969. An investigation of the ecological significance of lime-chlorosis by means of large-scale comparative experiments. In: Ecological Aspects of Mineral Nutrition. Rorison IH (ed). Oxford: Blackwell Scientific Publications, pp. 67-99.
44. vom Saal FS et al. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Natl Acad Sci USA 1997; 94: 2056-2061.
45. Ebert E, van Assche GJ. Influence of atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) on auxin metabolism of plants. Experientia 1969; 25: 758-759.
46. Morre DJ, Rogers BJ, Gamble R. Promotion of plant growth by long chain alcohols and organic solvents. Phyton 1965; 22 7-12.
47. Pillai GCP, Davis DE. S-Triazine effects on seed germination and hypocotyl hook opening. Weed Science 1973; 21: 461-464.
48. 2-adrenergic receptors in neuroblastoma X glioma hybrid cells. Mol Pharmacol 1982; 21: 17-26.
49. Parsons PA. Longevity of cosmopolitan and native Australian Drosophila in ethanol atmospheres. Aust J Zool 1981; 29: 33-39.
50. Neubort S et al. Morphological transformation, DNA strand separation, and antinucleoside immunoreactivity following exposure of cells to intercalating drugs. Mol Pharmacol 1982; 21: 739-743.
51. 3H]diazepam binding at the benzodiazepine-γ-aminobutyric acid receptor-ionophore complex. Mol Pharmacol 1981; 20: 287-294.
52. Smilowitz H. Monovalent ionophores inhibit acetylcholinesterase release from cultured chick embryo skeletal muscle cells. Mol Pharmacol 1979; 16: 202-214.
53. Fischer PWF, Stephens JK, Marks GS. Effect of varying the insulin to glucagon ratio on porphyrin biosynthesis in chick embryo liver cells. Mol Pharmacol 1978; 14: 717-721.
54. Domin BA, Cheng Y-C, Hakala MT. Properties of dihydrofolate reductase from a methotrexate-resistant subline of human KB cells and comparison with enzyme from KB parent cells and mouse S180 AT/3000 cells. Mol Pharmacol 1982; 21: 231-238.
55. Allender WJ 1995. The effects of sublethal concentrations of phytotoxins on plant growth. Dissertation, University of Sidney, Australia.
56. Blumberg AJ and Loefer JB. Effect of neomycin on two species of free living protozoa. Physiol Zool 1952; 27: 276-282.
57. Browne CL, Davis LE. Cellular mechanisms of stimulation of bud production in Hydra by low levels of inorganic lead compounds. Cell Tissue Res 1977; 177: 555-570.
58. Stromgren T. The effect of lead, cadmium, and mercury on the increase in length of five intertidal fucales. J Exp Mar Biol Ecol 1980; 43: 107-119.
59. Nickell LG, Finlay AC. Growth modifiers: antibiotics and their effects on plant growth. J Agric Food Chem 1954; 2: 178-182.
60. Dunstan WM, Atkinson LP, Natoli J. Stimulation and inhibition of phytoplankton growth by low molecular weight hydrocarbons. Mar Biol 1975; 31: 305-310.
61. Ramachandran R, Mukherjee SN, Sharma RN. Hormetic effect of azadirachtin on Tribolium castaneum (Herbst) (Voleoptera: Tenebrionidae). Indian J Exp Biol 1988; 269: 913-914.
62. Liu SZ. Radiation hormesis a new concept in radiological science. Chin Med J 1989; 102: 750-755.
63. Migicovsky BB, Nielson AM, Gluck M, Burgess R. Penicillin and calcium absorption. Arch Biochem Biophys 1951; 34: 479-481.
64. Thayer RH, Heller VG. Antibiotics and nitrogen utilization in growing cockerels. Poultry Sci 1955; 34: 97-102.
65. Ries SK, Gast A. The effects of simazine on nitrogenous components of corn. Weeds 1965; 13: 272-274.
66. Freney JR. Increased growth and uptake of nutrients by corn plants treated with low levels of simazine. Aust J Agric Res 1965; 16: 257-263.
67. Thayer RH. Role of antibiotics in modifying the energy, vitamin and protein requirements of chicks. Dissert Abstr 1956; 16: 424 (Abstr) J Sc Food and Agric 7: 191.
68. Thayer RH. Role of antibiotics in modifying the energy, vitamin and protein requirements of chicks. Dissert Abstr 1956; 16: 424 (Abstr) J Sc Food and Agric 7: 191.
69. Voelker HH, Jacobson NL, Allen RS. Relationship of antibiotic feeding and the rate of growth to blood reducing sugar levels of glucose absorption in dairy calves. Antibio Chemothera 1955; 5: 224-231.
70. Hertel R, Flory R. Auxin movement in corn coleoptiles. Planta 1968; 82: 123-144.
71. Ries SK, Chmiel H, Dilley DR, Filner P. The increase in nitrate reductase activity and protein content of plants treated with simazine. PNAS 1967; 58: 526-532.
72. Tweedy JA, Ries SK. Effect of simazine on nitrate reductase activity in corn. Plant Physiol 1967; 42: 280-282.
73. Spiegelman S, Reiner JM. Maxima in rate-concentration curves and their relation to the structural aspects of cellular metabolism. J Gen Physiol 1945; 28: 385-403.
74. Reiner JM. 1959; Behavior of Enzyme Systems. Burgess, Minneapolism Minnesota.
75. Webb JL. 1963. Enzyme and Metabolic Inhibitors. Vol. 1. Academic Press, NY.
76. Webb JL. 1966. Enzyme and Metabolic Inhibitors. Vol. 2. Academic Press, NY.
77. Webb JL. 1966a. Enzyme and Metabolic Inhibitors. Vol. 3. Academic Press, NY.
78. Southam CM, Ehrlich J. Effects of extract of western red-cedar heartwood on certain wood-decaying fungi in culture. Phytopathol. 1943; 33: 517-524.
79. Schultz H. Ueber Hefegifts. Pfugers Arch Ges Physiol 1888; 42 517-541.
80. Stebbing ARD. An experimental approach to the determinants of biological water quality. Phil Trans R Soc Lond B 1979; 286: 465-481.
81. Stebbing ARD. Stress, health and homeostasis. Mar Pollut Bull 1981a; 12: 326-329.
82. Parsons PA. Evolutionary adaptation and stress: The Fitness Gradient. Evol Biol 1992; 26: 191-223.
83. Hart RW, Frame LT. Toxicological defense mechanisms and how they may affect the nature of dose-response relationships. BELLE Newsletter 1996; 5: 1-16.
84. Selye H. 1975. From Dream To Discovery. Arno Press, NY.
85. Frenster JH. The magnitude of disease as measured by tolerance. J Theoret Biol 1962; 2: 159-164.
86. Frenster JH. Load tolerance as a quantitative estimate of health. Ann Intern Med 1962a; 57: 788-794.
87. Clark AJ. 1937. Handbook of Pharmacology. Verlag Von Julius Springer. Berlin.
88. Hugget RJ, Kimerle RA, Mehrle Jr PM, Bergman HL. 1992. Biomarkers: Biochemical Physiological, and Histological Markers of Anthropogenic Stress. Proceeding of the Eighth Pellston Workshop, July 23-28, 1989. Lewis Publishers, Chelsea, MI. pp. 347.
89. Welch WJ. How cells respond to stress. Sci Amer May 1993; pp. 56-64.
90. Pagliacci MC et al. Cellular stress and glucocorticoid hormones protect L929 mouse fibroblasts from tumor necrosis factor alpha cytotoxicity. J Endocrinol Invest 1993; 16: 591-599.