The I1-imidazoline receptor agonist moxonidine: Molecular, cellular and organismic actions

Reviews in Contemporary Pharmacotherapy

Volumn 9, Issue 7, 1998, Pages 441-462

  Ernsberger, Paul ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 4 CHLORO 2 (2 IMIDAZOLIN 2 YLAMINO)ISOINDOLINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; ALPHA 2 ADRENERGIC RECEPTOR; ARACHIDONIC ACID; CIMETIDINE; CIRAZOLINE; CLONIDINE; CORBADRINE; EFAROXAN; GUANFACINE; IDAZOXAN; IMIDAZOLINE RECEPTOR; INSULIN; MEDETOMIDINE; MOXONIDINE; NEUROTRANSMITTER RECEPTOR; PHOSPHOLIPID; PIPEROXAN; RAUWOLSCINE; RILMENIDINE; SODIUM;

ADRENAL MEDULLA; ADRENERGIC SYSTEM; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BRAIN FUNCTION; BRAIN STEM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; INSULIN RESISTANCE; KIDNEY; KIDNEY DISEASE; PREMOTOR CORTEX; SODIUM EXCRETION; SOMNOLENCE; STOMACH ACID SECRETION; XEROSTOMIA;

EID: 0031664041     PISSN: 09548602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Allan DR, Penner SB, Smyth DD. Antagonism by idazoxan at low dose but not high dose, of the natriuretic action of moxonidine. Er J Pharmacol 1996; 117: 29-34.
2. 2-adrenoceptor stimulation to the antihypertensive action of moxonidine. J Cardiovasc Pharmacol 1987; 10 (Suppl 4): S81-S83.
3. 2-receptor selectivity and specificity of the antihypertensive agent moxonidine. Arzneimittelforschung 1988; 38: 1435-1442.
4. Armah BI, Hofferber E, Stenzel W. General pharmacology of the novel centrally acting antihypertensive agent moxonidine. Arzneimittelforschung 1988; 38: 1426-1434.
5. 2-agonists: an in vivo voltammetry study. Neuropharmacology 1989; 28: 387-395.
6. 2 receptors by clonidine. Nature 1976; 262: 307-308.
7. Babbini M, Torrielly MY, Strumia E et al. Sedative-hypnotic properties of a new benzodiazepine in comparison with flurazepam - pharmacological and clinical findings. Arzneimittelforschung 1975; 25: 1294-1300.
8. Bailey PL, Sperry RJ, Johnson GK et al. Respiratory effects of clonidine, alone and combined with morphine, in humans. Anaesthesiology 1991; 74: 43-48.
9. Bamberger CM, Mönig H, Mill G et al. Growth hormone secretion in response to the new centrally acting antihypertensive agent moxonidine in normal human subjects: comparison to clonidine and GHRH. Exp Clin Endocrinol Diabetes 1995; 103: 205-208.
10. Bamford OS, Hawkins RL, Blanco CE. Effects of clonidine on breathing movements and electrocortical activity in the fetal lamb. Am J Obstet Gynecol 1990; 163: 661-668.
11. Barrios M, Robles I, Baeyens JM. Role of L-type calcium channels on yohimbine-precipitated clonidine withdrawal in vivo and in vitro. Naunyn-Schmiedebergs Arch Pharmacol 1993; 348: 601-607.
12. 2-adrenoceptor involvement in the central cardiovascular action of clonidine in the conscious renal hypertensive cat. Eur J Pharmacol 1982; 82: 155-160.
13. Benhamou D, Veillette Y, Narchi P, Ecoffey C. Ventilatory effects of premedication with clonidine. Anesth Analg 1991; 73: 799-803.
14. Berge K.H, Lanier WL. Myocardial infarction accompanying acute clonidine withdrawal in a patient without a history of ischemic coronary artery disease. Anesth Analg 1991; 72: 259-261.
15. Bhandare PN, Rataboli PV, Diniz D'Souza RS. Dual action of clonidine on ethanol-induced gastric lesions: is the imidazoline-preferring receptor involved. Eur J Pharmacol 1991; 199: 243-245.
16. 2-adrenoceptor stimulation. J Pharmacol Exp Ther 1988; 247: 1181-1186.
17. Bock JU, Van Zwieten PA. The central hyperglycemic effect of clonidine. Eur J Pharmacol 1971; 16: 303-310.
18. Bohmann C, Schollmeyer P, Rump LC. Effects of imidazolines on noradrenaline release in rat isolated kidney. Naunyn-Schmiedebergs Arch Pharmacol 1994; 349: 118-124.
19. Bousquet P. Recent advances in imidazoline receptor research. Exp Opin Invest Drugs 1995; 4: 431-442.
20. Bousquet P, Guertzenstein PG. Localization of the central cardiovascular action of clonidine. Br J Pharmacol 1973; 49: 573-579.
21. Bousquet P, Feldman J, Bloch R, Schwartz J. Central cardiovascular effects of α-adrenergic drugs: differences between catecholamines and imidazolines. J Pharmacol Exp Ther 1984; 230: 232-236.
22. 2-adrenoceptors and 'imidazoline receptors'. Am J Med 1989; 87 (Suppl 3C): 10S-13S.
23. Bricca G, Dontenwill M, Molines A et al. The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem. Eur J Pharmacol 1989a; 162: 1-9.
24. Bricca G, Dontenwill M, Molines A et al. Rilmenidine selectivity for imidazoline receptors in human brain. Eur J Pharmacol 1989b; 163: 373-377.
25. 3H]clonidine to identify imidazoline receptors in the rabbit brainstem. Br J Pharmacol 1993; 110: 1537-1543.
26. 3H]clonidine. Eur J Pharmacol Mol Pharmacol 1994; 266: 25-33.
27. 2-Adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br J Pharmacol 1990; 99: 803-809.
28. Browne SE, Macrae IM. Differential patterns of local cerebral glucose utilisation associated with rilmenidine- or B-HT 933-induced hypotension. Brain Res 1994: 666: 216-222.
29. 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats. J Pharmacol Exp Ther 1995; 273: 1162-1171.
30. 2-adrenoceptors: pharmacological and molecular biological evidence converge. Trends Pharmacol Sci 1988; 9: 356-361.
31. 2-adrenergic receptors. Int Rev Neurobiol 1983; 24: 343-431.
32. A, and alpha-2B adrenergic receptor subtypes: attenuation of cyclic AMP production in cell lines containing only one receptor subtype. J Pharmacol Exp Ther 1989; 251: 640-644.
33. Campbell WR, Potter DE. Centrally mediated ocular hypotension: potential role of imidazoline receptors. Ann N Y Acad Sci 1995; 763: 463-485.
34. Carlisle MA, Smyth DD, Glavin GB. Efaroxan acts peripherally to block the antisecretory and gastroprotective effects of moxonidine in rats. J Pharmacol Exp Ther 1995; 274: 598-601.
35. Cechetto DF, Kline RL. Effect of rilmenidine on arterial pressure and urinary output in the spontaneously hypertensive rat. Eur J Pharmacol 1997; 325: 47-55.
36. Chan CKS, Head GA. Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine. J Hypertens 1996; 14: 855-864.
37. Chan CKS, Sannajust F, Head GA. Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits. J Pharmacol Exp Ther 1996; 276: 411-420.
38. Coupry I, Atlas D, Podevin R-A et al. Imidazoline-guanidinium receptive site in renal proximal tubule: asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance. J Pharmacol Exp Ther 1990; 252: 293-299.
39. Csongrady A, Kobinger W. Investigations into the positive inotropic effect of clonidine in isolated hearts. Naunyn-Schmiedebergs Arch Pharmacol 1974; 282: 123-128.
40. Czerwiec E, Debacker JP, Flamez A, Vauquelin G. Identification and characterization of imidazoline-binding sites from calf striatum. Eur J Pharmacol 1996; 315: 99-109.
41. Darkwa FK, Smyth DD. Inhibition of the natriuretic action of the imidazoline receptor agonist moxonidine by indomethacin in the rat. Pharmacology 1995; 51: 347-355.
42. 2-adrenoceptors affect sleep and arousal mechanisms. Br J Pharmacol 1987; 90: 675-685.
43. De Sarro GB, Bagetta G, Ascioti C et al. Effects of pertussis toxin on the behavioural and ECoG spectrum changes induced by clonidine and yohimbine after their microinfusion into the locus coeruleus. Br J Pharmacol 1989; 96: 59-64.
44. Dinh Xuan AT, Matran R, Regnard J et al. Comparative effects of rilmenidine and clonidine on bronchial responses to histamine in asthmatic subjects. Br J Clin Pharmacol 1988; 26: 703-708.
45. Ditullio NW, Cieslinski L, Matthews WD, Storer B. Mechanisms involved in the hyperglycemic response induced by clonidine and other alpha-2 adrenoceptor agonists. J Pharmacol Exp Ther 1984; 228: 168-173.
46. 2 adrenoceptors. Anesthesiology 1989; 71: 75-79.
47. 2-adrenergic receptor subtypes in a cell type-specific manner. J Biol Chem 1992; 267: 24045-24052.