Amino acids and peptides. LII. Design and synthesis of opioid mimetics containing a pyrazinone ring and examination of their opioid receptor binding activity

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 9, 1998, Pages 1374-1382

  Okada, Yoshio ^a   Tsukatani, Masaki ^a   Taguchi, Hiroaki ^a   Yokoi, Toshio ^a   Bryant, Sharon D ^b   Lazarus, Lawrence H ^b  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

2(1H) pyrazinone; Amino containing pyrazinone derivative; Opioid receptor binding activity; Pyrazinone containing tyrosine derivative; Simple synthetic procedure

Indexed keywords

5 METHYL 6BETA PHENETHYL 3 TYROSYLAMINOBUTYL 2(1H) PYRAZINONE; AMINO ACID; DELTA OPIATE RECEPTOR; KETONE; MU OPIATE RECEPTOR; OPIATE PEPTIDE; OPIATE RECEPTOR; PEPTIDE; PYRAZINE DERIVATIVE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CYCLIZATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; RAT; SYNAPTIC MEMBRANE;

EID: 0031662143     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1374     Document Type: Article

References (28)

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