The μ- and δ-opioid pharmacophore conformations of cyclic β-casomorphin analogues indicate docking of the Phe3 residue to different domains of the opioid receptors

Journal of Computer-Aided Molecular Design

Volumn 10, Issue 3, 1996, Pages 201-212

  Brandt, Wolfgang ^a   Stoldt, Matthias ^a   Schinke, Heiko ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Cyclic casomorphins; Force field; Lipophilic potentials; Molecular electrostatic potentials; Pharmacophore conformations; And opioids

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; ELECTROSTATICS; HYDROGEN BONDS; MOLECULAR DYNAMICS; PEPTIDES; PHARMACODYNAMICS;

CYCLIC Β-CASOMORPHIN; DIFFERENT DOMAINS; FORCEFIELDS; LIPOPHILIC POTENTIAL; MOLECULAR ELECTROSTATIC POTENTIALS; OPIOID RECEPTORS; OPIOIDS; PHARMACOPHORE CONFORMATION; PHARMACOPHORES; Μ- AND Δ-OPIOID;

CONFORMATIONS;

BETA CASOMORPHINS; BETA-CASOMORPHINS; CYCLOPEPTIDE; DELTA OPIATE RECEPTOR; ENDORPHIN; MU OPIATE RECEPTOR; PHENYLALANINE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER GRAPHICS; COMPUTER SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION;

COMPUTER GRAPHICS; COMPUTER SIMULATION; ENDORPHINS; MODELS, MOLECULAR; PEPTIDES, CYCLIC; PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU;

EID: 0030159005     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00355043     Document Type: Article

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