Cytogenetic abnormalities and their lack of relationship to the Asp816Val c-kit mutation in the pathogenesis of mastocytosis

Journal of Allergy and Clinical Immunology

Volumn 102, Issue 3, 1998, Pages 523-524

  Worobec, Alexandra S ^a   Akin, Cern ^a   Scott, Linda M ^a   Metcalfe, D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CYTOGENETICS; DISEASE ASSOCIATION; ETIOLOGY; GENE MUTATION; HUMAN; KARYOTYPE; MASTOCYTOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRISOMY 8;

EID: 0031661591     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(98)70144-7     Document Type: Article

References (5)

1. Vliagoftis H, Worobec AS, Metcalfe DD. C-kit and c-kit ligand in human disease. J Allergy Clin Immunol 1997;100:435-40.
2. Worobec AS, Semere BS, Nagata H, Metcalfe DD. Clinical correlates of the presence of the Asp816Val mutation in the peripheral blood mononuclear cells of mastocytosis patients. Cancer. In press.
3. Nagata H, Worobec AS, Oh CK, Chowdhury BA, Tannenbaum S, Suzuki Y, et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA 1995;92:10560-4.
4. Swolin B, Rodjer S, Roupe G. Cytogenetic studies and in vitro colony growth in patients with mastocytosis. Blood 1987;70:1928-32.
5. Lishner M, Confino-Cohen R, Mekori YA, Feigin M, Manor Y, Goldberg A, et al. Trisomies 9 and 8 detected by fluorescence in situ hybridization in patients with systemic mastocytosis. J Allergy Clin Immunol 1996;98:199-204.