Effect of air pollutants on the pulmonary surfactant system

European Journal of Clinical Investigation

Volumn 28, Issue 9, 1998, Pages 762-777

  Muller B ^a   Seifart, C ^a   Barth, P J ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Alveolar macrophages; Asbestos; Biophysical activity; Clara cells; Nitric oxide; Nitrogen dioxide; Oxygen; Ozone; Secretion; Silica; Surfactant phospholipids; Surfactant proteins; Synthesis; Tobacco smoke; Type II pneumocytes

Indexed keywords

ASBESTOS; CIGARETTE SMOKE; LUNG SURFACTANT; NITROGEN DIOXIDE; OZONE; PHOSPHOLIPID; PROTEIN A; SILICON DIOXIDE;

AIR POLLUTION; DRUG DISTRIBUTION; DRUG SOLUBILITY; EXHAUST GAS; HUMAN; HYPEROXIA; LONG TERM EXPOSURE; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; LUNG TOXICITY; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW;

AIR POLLUTANTS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; HUMANS; LUNG; PHOSPHOLIPIDS; PROTEINS; PULMONARY SURFACTANTS;

EID: 0031661216     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1998.00342.x     Document Type: Review

References (179)

1. Bils RF, Christie BR. The experimental pathology of oxidant and air pollutant inhalation. Int Rev Exp Pathol 1980; 21: 195-293.
2. Chitano P, Hosselet JJ, Mapp CE, Fabbri LM. Effect of air pollutants on the respiratory system: insights from experimental animal research. Eur Respir J 1995; 8: 1357-71.
3. Haagsman HP. Toxicological aspects of the surfactant system. In: Robertson B, van Golde LMG, Batenburg JJ, eds. Pulmonary surfactant: from molecular biology to clinical practice. Amsterdam, Elsevier Science Publishers 1992: 705-34.
4. Hallman M, Enhorning G, Possmayer F. Composition and surface activity of normal and phosphatidylglycerol-deficient lung surfactant. Pediatr Res 1985; 19: 286-92.
5. Hallman M, Spragg R, Harrell JH, Moser KM, Gluck L. Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma inositol. J Clin Invest 1982; 70: 673-83.
6. Sagai M, Agrawa K, Ichinose T, Shimojo N. Biochemical effects of combined gases of nitrogen dioxide and ozone. I. Species differences of lipid peroxides and phospholipids in lung. Toxicology 1987; 46: 251-65.
7. Baron J, Voigt JM. Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung. Pharmac Ther 1990; 47: 419-45.
8. King RJ. Isolation and chemical composition of pulmonary surfactant. In: Robertson, B, van Golde, LMG, Batenburg JJ, eds. Pulmonary surfactant. Amsterdam, Elsevier Science Publishers 1984: 1-16.
9. Clements JA, Tierney DF. Alveolar instability associated with altered surface tension. In: Fenn WO, Rahn H, eds. Handbook of Pphysiology - Respiration, Sect. 3, Vol. II. Washington, American Physiological Society 1965: 1565-83.
10. King RJ. Pulmonary surfactant. J Appl Physiol 1982; 53: 1-8.
11. Avery MA, Mead J. Surface properties in relation to atelectasis and hyaline membrane disease. Am J Dis Child 1959; 97: 517-23.
12. Fujiwara T, Maeta H, Chida S, Morita T, Watabe A, Abe T. Artificial surfactant therapy in hyaline-membrane disease. Lancet 1980; I: 55-9.
13. Lewis JK, Jobe AH. Surfactant and adult respiratory distress syndrome. Am Rev Respir Dis 1993; 147: 218-33.
14. Chevalier G, Collet AJ. In vivo incorporation of choline-3H and galactose-3H in alveolar type II pneumocytes in relation to surfactant synthesis. A quantitative and radioautographic study in mouse by electron microscopy. Anat Rec 1972; 174: 289-310.
15. Wright JR, Clements JA. Metabolism and turnover of lung surfactant. Am Rev Respir Dis 1987; 135: 426-44.
16. King RJ, Clements JA. Surface active material from dog lung. II. Composition and physiological correlation. Am J Physiol 1972; 223: 715-26.
17. Clements JA. Functional lining of the alveoli. Am Rev Respir Dis 1977; 115: 67-71.
18. Rooney SA. The surfactant system and lung phospholipid biochemistry. Am Rev Respir Dis 1985; 131: 439-60.
19. van Golde LMG. Metabolism of phospholipids in the lung. Am Rev Respir Dis 1986; 114: 977-1000.
20. Batenburg JJ. Surfactant phospholipids: synthesis and storage. Am J Physiol 1992; 262: L367-85.
21. Johansson J, Curstedt T, Robertson B. The proteins of the surfactant system. Eur Respir J 1994; 7: 372-91.
22. Hawgood S, Benson BJ, Schilling J, Damm D, Clements JA, White RT. Nucleotide and amino acid sequence of pulmonary surfactant protein SP 18 and evidence for cooperation between SP 18 and SP 28-36 in surfactant lipid adsorption. Proc Natl Acad Sci USA 1987; 84: 66-70.
23. Hawgood S, Benson BJ, Hamilton RL. Effects of a surfactant-associated protein and calcium ions on the structure and surface activity of lung surfactant lipids. Biochemistry 1985; 24: 184-90.
24. Pison U, Shiffer K, Hawgood S, Goerke J. Effects of the surfactant-associated proteins SP-A, SP-B and SP-C on phospholipid surface film formation. Progr Respir Res 1990; 25: 271-3.
25. Yu SH, Possmayer F. Role of bovine pulmonary surfactant-associated proteins in the surface active property of phospholipid mixtures. Biochim Biophys Acta 1990; 1046: 233-41.
26. Williams MC, Hawgood S, Hamilton RL. Changes in lipid structure produced by surfactant proteins SP-A, SP-B, and SP-C. Am J Respir Cell Mol Biol 1991; 5: 41-50.
27. Dobbs LG, Wright JR, Hawgood S, Gonzalez R, Venstrom K, Nellenbogen J. Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells. Proc Natl Acad Sci USA 1987; 84: 1010-4.
28. Rice WR, Ross GF, Singleton FM, Dingle S, Whitsert JA. Surfactant-associated protein (SAP 35) inhibits phospholipid secretion from type II cells. J Appl Physiol 1987; 63: 692-8.
29. Wright JR, Wager RE, Hawgood S, Dobbs LG, Clements JA. Surfactant apoprotein Mr=26,000-36,000 enhances uptake of liposomes by type II cells. J Biol Chem 1987; 262: 2888-94.
30. Wright JR, Dobbs LG. Regulation of pulmonary surfactant secretion and clearance. Ann Rev Physiol 1991; 43: 395-414.
31. Pison U, Max M, Neuendank A, Weißbach S, Pietschmann S. Host defence capacities of pulmonary-surfactant: evidence for 'non-surfactant' functions of the surfactant system. Eur J Clin Invest 1994; 24: 586-99.
32. La Force FM, Kelley WJ, Huber GL. Inactivation of staphylococci by alveolar macrophage with preliminary observations on the importance of alveolar lining material. Am Rev Respir Dis 1973; 108: 783-90.
33. Van Iwaarden JF, Welmers AC, Verhoef J, Haagsman HP, Van Golde LMG. Pulmonary surfactant protein A enhances the host-defence mechanism of rat alveolar macrophages. Am J Respir Cell Mol Biol 1990; 2: 91-8.
34. van Iwaarden JF, Shimizu H, van Golde PHM, Voelker DR, van Golde LMG. Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages. Biochem J 1992; 286: 5-8.
35. Van Iwaarden JF, Van Strijp AG, Ebskamp MJM, Welmers AC, Verhoef J, Van Golde LMG. Surfactant protein A is opsonin in phagocytosis of herpes simplex virus type 1 by rat alveolar macrophages. Am J Physiol 1991; 261: L204-9.
36. Pikaar JC, Voorhout WF, van Golde LMG, Verhoef J, van Strijp JAG, van Iwaarden JF. Opsonic activities of surfactant proteins A and D in phagocytosis of gram-negative bacteria by alveolar macrophages. J Infect Dis 1995; 172: 481-9.
37. Kuan SF, Rust D, Crouch E. Interactions of surfactant protein D with bacterial lipopolysaccharides. Surfactant protein D is an Escherichia coli binding protein in bronchoalveolar lavage. J Clin Invest 1992; 90: 97-106.
38. Wright JR, Youmans DC. Pulmonary surfactant protein A stimulates chemotaxis of alveolar macrophage. Am J Physiol 1993; 264: L338-44.
39. Kremlev SG, Phelps DS. Surfactant protein A stimulation of inflammatory cytokine and immunoglobulin production. Am J Physiol 1994; 267: L712-9.
40. Balu H, Riklis S, Kravtsov V, Kalina M. Secretion of cytokines by rat alveolar epithelial cells - Possible regulatory role for SP-A. Am J Physiol 1994; 266: L148-55.
41. Yukitake K, Brown CL, Schlueter MA, Clements JA, Hawgood S. Surfactant apoprotein A modifies the inhibitory effect of plasma proteins on surfactant activity in vitro. Pediat Res 1995; 37: 21-5.
42. Fishbein L. Sources, nature and levels of air pollutants. In: Tomatis L, ed. Indoor and outdoor air pollution and human cancer. Berlin, Springer 1993: 17-66.
43. Chrzanowski P, Keller S, Cerrata J, Mandel I, Turino GM. Elastin contents of normal and emphysematous lung. Am J Med 1980; 69: 351-8.
44. Norman V, Keith CH. Nitrogen oxides in tobacco smoke. Nature 1965; 205: 915-6.
45. Mohsenin V. Airway responses to 2.0 ppm nitrogen dioxide in normal subjects. Arch Environ Health 1988; 43: 242-6.
46. Pepke-Zaba J, Higgenbottam TW, Dingh-Xuang A, Stone D, Wallwork J. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet 1991; 338: 1173-4.
47. Foubert L, Fleming B, Latimer R, Joanas M, Oduro A, Borland C, Higgenbottam T. Safety guidelines for use of nitric oxide. Lancet 1992; 339: 1615-6.
48. Yanai M, Ohrui T, Aikawa T et al. Ozone increases susceptibility to antigen inhalation in allergic dogs. J Appl Physiol 1990; 68: 2267-73.
49. Whitten GZ. The chemistry of smog formation: a review of current knowledge. Environ Int 1983; 9: 447-63.
50. Elstner EF, Oßwald W. Air pollution: involvement of oxygen radicals (a mini review). Free Rad Res Commun 1991; 12-13: 795-807.
51. Hanna LA, Frank R, Scherer PW. Absorption of soluble gases and vapours in the respiratory system. In: Chang HK, Paiva M, eds. Respiratory physiology - an analytical approach. Basle, Marcel Dekker 1989: 277-316.
52. Clark SW, Pavia, D. Mucociliary Clearance. In: Crystal RG, West JB, eds. The lung. New York, Raven Press 1991: 1845-59.
53. Hippeli S, Elstner EF. Oxygen radicals and air pollution. In: Sies H, ed. Oxidative stress: oxidants and antioxidants. London, Academic Press 1991: 3-55.
54. 2 through pulmonary epithelial lining fluid. Toxicol Appl Pharmacol 1991; 109: 464-71.
55. Postlethwait EM, Langford SD, Bidani. A. Reactive absorption of nitrogen dioxide by pulmonary epithelial lining fluid. J Appl Physiol 1990; 69: 523-31.
56. 2 absorption. Toxicology 1994; 89: 217-37.
57. 2 reactive absorption substrates in rat pulmonary surface lining fluids. Free Rad Biol Med 1995; 19: 553-63.
58. 2 in the rat and hamster. Br J Exp Path 1985; 66: 193-204.
59. Ichinose T, Sagai M. Biochemical effects of combined gases of nitrogen dioxide and ozone. III. Synergistic effects on lipid peroxidation and antioxidative protective systems in the lungs of rats and guinea pigs. Toxicology 1989; 59: 259-70.
60. Ichinose T, Sagai M. Biochemical effects of combined gases of nitrogen dioxide and ozone. IV. Changes of lipid peroxidation and antioxidative protective systems in rat lungs upon life span exposure. Toxicology 1989; 66: 121-32.
61. Sagai M, Ichinose T. Biochemical effects of combined gases of nitrogen dioxide and ozone. I. Species differences of lipid peroxide and phospholipids in lungs. Toxicology 1987; 46: 251-65.
62. 2 as markers of altered surfactant metabolism. Lung 1994; 172: 61-72.
63. 3H]thymidine into DNA. Environ Res 1982; 27: 352-60.
64. Guth DJ, Mavis RD. Biochemical assessment of acute nitrogen dioxide toxicity in rat lung. Toxicol Appl Pharmacol 1985; 81: 128-38.
65. Williams RA, Rhoades RA, Adams WS. The response of lung tissue and surfactant to nitrogen dioxide exposure. Arch Int Med 1971; 128: 101-8.
66. Dowell AR, Kilburn KH, Pratt PC. Short-term exposure to nitrogen dioxide. Arch Int Med 1971; 128: 74-91.
67. Arner EC, Rhoades RA. Long-term nitrogen dioxide exposure. Arch Environ Health 1973; 26: 156-60.
68. Treciak HI, Kosmider S, Kryk A. The effects of nitrogen oxides and their neutralisation products with ammonia on the lung phospholipids of guinea pigs. Environ Res 1971; 14: 87-91.
69. Clements JA. Surface tension of lung extracts. Soc Exp Biol Med 1957; 95: 170-2.
70. Goerke J. Lung surfactant. Biochim Biophys Acta 1974; 344: 241-61.
71. Blank ML, Dalbey W, Nettesheim P, Price J, Creasia D, Snyder F. Sequential changes in phospholipid composition and synthesis in lungs exposed to nitrogen dioxide. Am Rev Respir Dis 1978; 117: 273-80.
72. Leung HW Effect of nitrogen dioxide exposure on rat lung lipids. Res Commun Chem Pathol Pharmacol 1983; 40: 519-22.
73. Roehm JN, Hadley JC, Menzel DB. Oxidation of unsaturated fatty acids by ozone and nitrogen dioxide. Arch Environ Health 1972; 23: 142-8.
74. Frostell CG. Clinical aspects of nitric oxide and surfactant replacement. Biol Neonate 1997; 71 (Suppl. 1): 9-43, .
75. Hallman M, Waffarn F, Bry K et al. Surfactant dysfunction after inhalation of nitric oxide. J Appl Physiol 1996; 80: 2026-34.
76. Hallman M, Bry K, Lappalainen U. A mechanism of nitric oxide-induced surfactant dysfunction. J Appl Physiol 1996; 80: 2035-43.
77. Matalon S, Demarco V, Haddad IY et al. Inhaled nitric oxide injures the pulmonary surfactant system of lambs in vivo. Am J Physiol 1996; 14: L273-L280.
78. Wright ES, White DM, Smiler KL. Effects of chronic exposure to ozone on pulmonary lipids in rats. Toxicology 1990; 64: 313-24.
79. Putman E, Boere AJF, van Bree L, van Golde LMG, Haagsman HP. Pulmonary surfactant subtype metabolism is altered after short-term ozone exposure. Toxicol Appl Pharmacol 1995; 134: 132-8.
80. Putman E, Liese W, Voorhout WF, van Bree L, van Golde LMB, Haagsman HP. Short-term ozone exposure affects the surface activity of pulmonary surfactant. Toxicol Appl Pharmacol 1997; 142: 288-96.
81. Rao GA, Larkin EC, Harkema JR, Dungworth DL. Changes in lipids of lung lavage in monkeys after chronic exposure to ambient levels of ozone. Toxicol Lett 1985; 29: 207-14.
82. Roehm JN, Hadley JG, Menzel DB. The influence of vitamin E on the lung fatty acids of rats exposed to ozone. Arch Environ Health 1972; 24: 237-42.
83. Mautz WJ, Finlayson-Pitts BJ, Messer K, Kleinmann MT, Norgren MB, Quirion J. Effects of ozone combined with components of acid fogs on breathing pattern, metabolic rate, pulmonary surfactant composition, and lung injury in rats. Inhal Toxicol 1991; 3: 1-25.
84. Nachtman JP, Hajratwala BR, Moon HL, Gross KB, Wright ES. Surface-tension measurements of pulmonary lavage from ozone-exposed rats. J Toxicol Environ Health 1986; 19: 127-36.
85. Goad MEP, Tryka AF, Witschi HP. Surfactant alterations following acute bleomycin and hyperoxia-induced lung damage. Toxicol Lett 1986; 32: 173-8.
86. Holm BA, Notter RH, Siegle J, Matalon S. Pulmonary physiological and surfactant changes during injury recovery from hyperoxia. J Appl Physiol 1985; 59: 1402-9.
87. Pison U, Seeger W, Buchhorn R et al. Surfactant abnormalities in patients with respiratory failure following multiple trauma. Am Rev Respir Dis 1989; 140: 1033-9.
88. 2-and pneumonia-induced lung injury. II. Properties of pulmonary surfactant. J Appl Physiol 1989; 67: 357-65.
89. Rosen SH, Castleman B, Liebow AA. Pulmonary alveolar proteinosis. N Engl J Med 1958; 258: 1123-42.
90. Ramierez RJ, Harlan WK. Pulmonary alveolar proteinosis. Nature and origin of alveolar lipid. Am J Med 1968; 45: 502-12.
91. Richards RJ, Hunt J, George G. Pulmonary surfactant and mineral-induced diseases. In: Cosmi EV, Scarpelli EM, eds. Pulmonary surfactant system. Amsterdam, Elsevier Science Publishers 1983: 287-291.
92. Richards RJ, Curtis CG. Biochemical and cellular mechanisms of dust induced lung fibrosis. Environ Health Perspect 1984; 55: 393-416.
93. Hepplestone AG. Pulmonary toxicology of silica, coal and asbestos. Environ Health Perspect 1984; 55: 111-27.
94. Deseau R, Hext PM, Richards RJ. The prevention of asbestos-induced hemolysis. Life Sci 1975; 16: 1931-8.
95. Tetley TD, Richards RJ, Harwood JL. Changes in pulmonary surfactant and phosphatidylcholine metabolism in rats exposed to chrysotile asbestos dust. Biochem J 1977; 116: 449-57.
96. Kornbrust DJ, Hatch GR. Effect of silica and volcanic ash on the contents of lung alveolar and tissue phospholipids. Environ Res 1984; 35: 140-53.
97. Eskelson CD, Chvapil M, Strom KA, Vostal JJ. Pulmonary phospholipidosis in rats respiring air containing diesel particulates. Environ Res 1984; 44: 260-71.
98. Finley TN, Ladman AJ. Low yield of pulmonary surfactant in cigarette smokers. N Engl J Med 1972; 286: 223-7.
99. Cook WD, Webb WR. Surfactant in chronic smokers. Ann Thorac Surg 1966; 2: 327-33.
100. 2 inhalation. Toxicol Appl Pharmacol 1981; 60: 301-12.
101. Honda Y, Takahashi H, Shijubo N, Kuroki Y, Akino T. Surfactant protein A-concentration in bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosis. Chest 1993; 103: 496-9.
102. Crouch ED, Persson A, Chang D. Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. Am J Pathol 1995; 142: 241-8.
103. Kawada H, Horiuchi T, Shannon JM, Kuroki Y, Voelker DR, Hook GER. Alveolar type II cells, surfactant protein a (SP-A), and the phospholipid components of surfactant in acute silicosis in the rat. Am Rev Respir Dis 1989; 140: 460-70.
104. Honda Y, Takajashi H, Kuroki Y, Akino T, Abe S. Decreased contents of surfactant proteins A and D in BAL fluids of healthy smokers. Chest 1996; 109: 1006-9.
105. Subramaniam S, Whitsett JA, Hull W, Gairola CG. Alteration of pulmonary surfactant proteins in rats chronically exposed to cigarette smoke. Toxicol Appl Pharmacol 1996; 140: 274-80.
106. Nogee LM, Wispé JR. Effects of pulmonary oxygen injury on airway contents of surfactant-associated protein A. Pediatr Res 1988; 24: 568-73.
107. Nogee LM, Wispé JR, Clark JC, Whitsett JA. Increased synthesis and mRNA of surfactant protein a in oxygen-exposed rats. Am J Respir Cell Mol Biol 1989; 1: 119-25.
108. Nogee LM, Wispé JR, Clark JC, Weaver TE, Whitsett JA. Increased expression of pulmonary surfactant proteins in oxygen-exposed rats. Am J Respir Cell Mol Biol 1991; 4: 102-7.
109. Treciak HI, Kosmider S, Kryk A. The effects of nitrogen oxides and their neutraliaztion products with ammonia on the lung phospholipids of guinea pigs. Environ Res 1971; 14: 87-91.
110. Finlayson-Pitts BJ, Mautz WJ, Lai CC et al. Are changes in breathing pattern on exposure to ozone related to changes in pulmonary surfactant? Inhal Toxicol 1994; 6: 74-91.
111. Shimanski H, Takatori T, Anderson WR, Horton HK, Privett OS. Alteration of lung lipids in ozone exposed rats. Biochem Biophys Res Commun 1976; 68: 1256-62.
112. Müller B, Barth P, von Wichert P. Structural and functional impairment of surfactant protein A after exposure to nitrogen dioxide. Am J Physiol 1992; 263: L177-84.
113. Haddad I, Zhu S, Schiropoulos H, Matalon S. Nitration of surfactant protein A results in decreased ability to aggregate lipids. Am J Physiol 1994; 270: L281-8.
114. Haddad IY, Crow JP, Hu PYeY, Beckman J, Matalon S. Concurrent generation of nitric oxide and superoxide damages surfactant protein A. Am J Physiol 1994; 267: L242-9.
115. Oosting RS, van Greevenbroek MMJ, Verhoef J, van Golde LMG, Haagsman HP. Structural and functional impairment of surfactant protein A induced by ozone. Am J Physiol 1991; 261: L77-L83.
116. Balis JU, Paterson JF, Lundh JM, Haller EM, Shelley SU, Montgomery MR. Ozone stress initiates acute pertubations of secreted surfactant membranes. Am J Pathol 1991; 138: 847-57.
117. Oosting RS, van Iwaarden JF, van Bree L, van Golde LMG, Haagsman HP. Exposure of surfactant protein A to ozone in vitro and in vivo impairs its interaction with alveolar cells. Am J Physiol 1992; 262: L63-L68.
118. Bascom R, Bromberg PA, Costa DA et al. Health effects of outdoor air pollution (State of the Art, part I). Am J Respir Crit Care Med 1996; 153: 3-50.
119. Basc.om R, Bromberg PA, Costa DA et al. Health effects of outdoor air pollution (State of the Art, part II). Am Respir J Crit Care Med 1996; 153: 477-98.
120. Wright ES, Mavis RD. Changes in pulmonary phospholipid biosynthetic enzymes after nitrogen dioxide exposure. Toxicol Appl Pharmacol 1981; 58: 262-8.
121. 2 exposure. Toxicol Appl Pharmacol 1982; 66: 305-11.
122. Müller B, von Wiehert P. Effect of nitrogen dioxide inhalation on surfactant phosphatidylcholine synthesis in rat alveolar type II cells. Biochim Biophys Acta 1993; 1170: 38-43.
123. Van Bree L, Haagsman HP, van Golde LMG, Rombout PJA. Phosphatidylcholine synthesis in isolated type II pneumocytes from ozone-exposed rats. Arch Toxicol 1988; 61: 224-8.
124. Haagsman HP, Schuurmans EAJM, Alink GM, Batenburg JJ, van Golde LMG. Effects of ozone on phospholipid synthesis by alveolar type II cells isolated from adult rat lung. Exp Lung Res 1985; 9: 67-84.
125. Haagsman HP, Schuurmans EAJM, Batenburg JJ, van Golde LMG. Synthesis of phosphatidylcholines in ozone-exposed alveolar type II cells isolated from adult rat lung: Is glycerolphosphate acyltransferase a rate-limiting enzyme? Exp Lung Res 1988; 14: 1-17.
126. Holm BA, Matalon S, Finkelstein. JN, Notter RH. Type II pneumocytes change during hyperoxic lung injury and recovery. J Appl Physiol 1988; 65: 2672-8.
127. Kennedy KA, Snyder JM, Stenzel W, Saito S, Warshaw JB. Vitamin E alters alveolar type II cells after phospholipid synthesis in oxygen and air. Exp Lung Res 1990; 16: 607-15.
128. Miller BE, Hook GER. Stimulation of surfactant phospholipid biosynthesis in the lungs of rats treated with silica. Biochem J 1988; 253: 659-65.
129. Lewis RW, Harwood JL, Richards RJ. The fate of instilled pulmonary surfactant in normal and quartz-treated rats. Biochem J 1987; 243: 679-85.
130. Miller BE, Hook GER. Regulation of phosphatidylcholine biosynthesis in activated alveolar type II cells. Am J Respir Cell Mol Biol 1989; 1: 127-36.
131. Würtemberger G, Herceg R, Matthys H, Ferber E, Costabel U. Surfactant-Phospholipide der BAL-Flüssigkeit bei lungengesunden Rauchern und Nichtrauchern. Pneumologie 1990; 44: 310-1.
132. Giammona S-T, Tocci P, Webb WR. Effects of cigarette smoke on incorporation of radioisotopically labelled palmitic acid into pulmonary surfactant and on surface activity of canine lung extracts. Am Rev Respir Dis 1971; 104: 358-67.
133. Miller BE, Bakewell WE, Katyal SL, Singh G, Hook GER. Induction of surfactant protein biosynthesis and SP-A mRNA in activated type II cells during acute silicosis in rats. Am J Resp Cell Mol Biol 1990; 3: 217-26.
134. Rami J, Stenzel W, Sasic SM et al. Fatty-acid synthase activity and mRNA level in hypertrophic type II cells from silica-treated rats. Am J Physiol 1994; 267: L128-36.
135. Minoo P, King RJ, Coalson JJ. Surfactant proteins and lipids are regulated independently during hyperoxia. Am J Physiol 1992; 263: L291-8.
136. Horowitz S, Watkins RH, Auten RL, Mercier CE, Cheng ERY. Differential accumulation of surfactant protein A, B, C mRNAs in two epithelial cell types of hyperoxic lung. Am J Resp Cell Mol Biol 1991; 5: 511-5.
137. Acarregui MJ, Brown JJ, Mallampalli RK. Oxygen modulates surfactant protein mRNA expression and phospholipid production in human fetal lung in vitro. Am J Physiol 1995; 268: L818-25.
138. Wilkenheiser A, Wert SE, Wispe JR et al. Distinct effects of oxygen on surfactant protein B expression in bronchiolar and alveolar epithelium. Am J Physiol 1992; 262: L32-9.
139. O'Reilly MA, Clark JC, Whitsett JA. Glucocorticoid enhances pulmonary surfactant protein B gene transcription. Am J Physiol 1991; 260: L37-L43.
140. Su WS, Gordon T. Alterations in surfactant protein A after acute exposure to ozone. J Appl Physiol 1997; 80: 1560-7.
141. Kelly FJ, Birch S. Pulmonary protein synthesis response to ozone. Human Exp Toxicol 1994; 13: 407-10.
142. Royce FH, Plopper CG. Effect of chronically daily ozone exposure on Clara cell secretory protein mRNA express in the adult rat lung. Exp Lung Res 1997; 23: 51-64.
143. Müller B, Barth PJ, Bittinger A, von Wiehert P. Impairment of surfactant metabolism in type II pneumocytes after in vivo exposure to nitrogen dioxide. Am Rev Respir Dis 1993; 147: A986.
144. Warburton D, Buckley S, Cosico L, Forman HJ. Sublethal oxidant injury inhibits signal transduction in rat type II pneumocytes. Am J Physiol 1989; 25: L217-L220.
145. Wirtz HRW, Schmidt M. Acute influence of cigarette smoke on secretion of pulmonary surfactant in rat alveolar type II cells in culture. Eur Respir J 1996; 9: 24-32.
146. Ghia AJ, Kennedy TP, Schapira RM, Crumbliss AL, Hoidal JR. Hypothesis: is lung disease after silicate inhalation caused by oxidant generation? Lancet 1990; 336: 967-9.
147. 2 by AgNOR-analysis. Exp Toxicol Pathol 1994; 46: 335-42.
148. Gelzleichtner TR, Witschi H, Last JA. Concentration-response relationships of rat lungs to exposure to oxidant air pollutants: a critical test of Haber's law for ozone and nitrogen dioxide. Toxicol Appl Pharmacol 1992; 112: 73-80.
149. Mercer RR, Costa DL, Crapo JD. Effects of prolonged exposure to low doses of nitric oxide or nitrogen dioxide on the alveolar seta of the adult rat lung. Lab Invest 1995; 73: 20-8.
150. Chang LY, Crapo JD. Quantitative evaluation of minimal injuries. In: Gil J. ed. Models of lung disease, microscopy and structural methods. New York, Marcel Dekker 1990: 597-640.
151. 2 toxicity in neonate and adult guinea pigs and rats. Environ Res 1983; 30: 322-39.
152. Katzenstein AA, Bloor CM, Liebow AA. Diffuse alveolar damage - the role of oxygen, shock, and related factors. Am J Pathol 1976; 85: 210-8.
153. 2. Exp MoL Pathol 1975; 22: 142-50.
154. 3. Lab Invest 1976; 35: 246-57.
155. Evans MJ, Cabral-Anderson L, Freeman G. Role of the Clara cell in renewal of the bronchiolar epithelium. Lab Invest 1978; 38: 648-56.
156. 2. Am J Pathol 1986; 123: 126-33.
157. Jetten AM. Growth and differentiation factors in tracheobronchial epithelium. Am J Physiol 1991; 260: L361-L373.
158. Vincent R, Bjarnason SG, Adamson IYR et al. Acute pulmonary toxicity of urban particulate matter and ozone. Am J Pathol 1997; 151: 1563-70.
159. Brody AR, Roe MW. Deposition pattern of inorganic particles at the alveolar level in the lungs of rats and mice. Am Rev Respir Dis 1983; 128: 724-9.
160. Robinson FR, Runnels RJ, Conrad DA, Teclaw RF, Thacker HL. Pathologic response of the lung to irritant gases. Vet Hum Toxicol 1990; 32: 569-72.
161. Shimura S, Maeda S, Takismima T. Giant lamellar bodies in alveolar type II cells of rats exposed to low doses of ozone. Respiration 1984; 46: 303-9.
162. Balis JU, Paterson JF, Haller EM, Shelley SA, Montgomery MR. Ozone-induced lamellar body responses in a rat model for alveolar injury and repair. Am J Pathol 1988; 132: 330-44.
163. Barth PJ, Uhlarik S, Bittinger A, Wagner U, Rüschoff J. Diffuse alveolar damage in the rat lung after short and long term exposure to nitrogen dioxide. Path Res Pract 1994; 190: 33-41.
164. Panos RJ, Suwabe A, Leslie CC, Mason RJ. Hypertrophic alveolar type II cells from silica-treated rats are committed to DNA-synthesis in vitro. Am J Respir Cell Mol Biol 1990; 3: 51-9.
165. 2 in rats by AgNOR analysis. In: Herzog H, ed. Lung surfactant: basic research in the pathogenesis of lung disorders. Prog Respir Dis. Basel: Karger, 1994; 27: 169-72.
166. Rajini P, Gelzleichtner TR, Last JA, Witschi H. Alveolar and airway cell kinetics in the lungs of rats exposed to nitrogen dioxide, ozone, and a combination of the two gases. Toxicol Appl Pharmacol 1993; 121: 186-92.
167. King RJ. Changes in proliferation and function of lung cells during acute lung injury. In: Müller B, von Wichert P, eds. Lung surfactant: basic research in the pathogenesis of lung disorders. Prog Respir Dis. Basel: Karger, 1994; 27: 185-94.
168. Wahrheit DB, Chang L, Hill L, Hook GER, Crapo JD. Pulmonary macrophage accumulation and asbestos-induced lesions at sites of fibre deposition. Am Rev Respir Dis 1984; 129: 301-10.
169. Heller R, Gordon RE. Chronic effects of nitrogen dioxide on cilia in hamster bronchioles. Exp Lung Res 1986; 10: 137-52.
170. Case BW, Gordon RE, Kleinerman J. Acute bronchiolar injury following nitrogen dioxide exposure: a freeze fracture study. Environ Res 1982; 29: 399-413.
171. 2 decreases paracellular resistance to ion and solute flow in alveolar epithelial monolayers. Exp Lung Res 1990; 16: 561-75.
172. Kawakami M, Yasui S, Yamawaki I, Katayama M, Nagai A, Takizawa T. Structural changes in airways of rats exposed to nitrogen dioxide intermittently for seven days. Am Rev Respir Dis 1989; 140: 1754-62.
173. Barth PJ, Wolf M, Ramaswamy A. Number and distribution of Clara Cells in normal and disturbed lung growth. Pediatr Pathol 1994; 14: 637-51.
174. Drechsler-Parks DM. Effect of nitrogen dioxide, ozone, and peroxyacetyl nitrate on metabolic and pulmonary function. Health Effects Inst Res Report 1987; 6: 3-34.
175. Kulle TJ, Clements ML. Susceptibility to virus infections with exposure to nitrogen dioxide. Health Effects Inst Res Report 1988; 15: 5-22.
176. Jakab GJ. Modulation of pulmonary defence mechanisms against viral and bacterial infections by acute exposure to nitrogen dioxide. Health Effects Inst Res Report 1988; 20: 1-38.
177. Morrow PE, Utell MJ. Responses of susceptible subpopulations to nitrogen dioxide. Health Effects Inst Res Report 1989; 23: 1-45.
178. Koenig JQ, Covert DS, Pierson WE et al. Effects of oxidants, combined with sulfuric or nitric acid, on the pulmonary function of adolescents with asthma. Health Effects Inst Res Report 1994; 70: 1-36.
179. Utell MJ, Frampton MW, Morrow PE et al. Exposures of sequential sulfuric acid and ozone exposures on the pulmonary function of healthy subjects and subjects with asthma. Health Effects Inst Res Report 1994; 70: 1-36.