Characterization of In40 of Enterobacter aerogenes BM2688, a class 1 integron with two new gene cassettes, cmlA2 and qacF

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 10, 1998, Pages 2557-2563

  Ploy, Marie Cécile ^a,b   Courvalin, Patrice ^a   Lambert, Thierry ^a,c  

^a INSTITUT PASTEUR   (France)

^b DUPUYTREN UNIVERSITY HOSPITAL   (France)

^c Centre Pharmaceutique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; QUATERNARY AMMONIUM DERIVATIVE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; DNA DETERMINATION; DNA SEQUENCE; ENTEROBACTER AEROGENES; GENE CASSETTE; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC ANALYSIS; INTEGRON; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0031660763     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.10.2557     Document Type: Article

References (42)

1. Bissonnette, L., S. Champetier, J. P. Buisson, and P. H. Roy. 1991. Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins. J. Bacteriol. 173:4493-4502.
2. Bissonnette, L., and P. H. Roy. 1992. Characterization on In0 of Pseudomonas aeruginosa plasmid pVS1, an ancestor of integrons of multiresistance plasmids and transposons of gram-negative bacteria. J. Bacteriol. 174:1248-1257.
3. Bunny, K. L., R. M. Hall, and H. W. Stokes. 1945. New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301. Antimicrob. Agents Chemother. 39:686-693.
4. Collis, C. M., and R. M. Hall. 1992. Site-specific deletion and rearrangement of integron insert genes catalyzed by the integron DNA integrase. J. Bacteriol. 174:1574-1585.
5. Collis, C. M., and R. M. Hall. 1992. Gene cassettes from the insert region of integrons are excised as covalently closed circles. Mol. Microbiol. 6:2875-2885.
6. Collis, C. M., and R. M. Hall. 1995. Expression of antibiotic resistance genes in the integrated cassettes of integrons. Antimicrob. Agents Chemother. 39:155-162.
7. Dorman, C. J., and T. J. Foster. 1985. Posttranscriptional regulation of the inducible nonenzymatic chloramphenicol resistance determinant on IncP plasmid R26. J. Bacteriol. 161:147-152.
8. Francia, M. V., F. de la Cruz, and J. M. G. Lobo. 1993. Secondary sites for integration mediated by the Tn21 integrase. Mol. Microbiol. 10:823-828.
9. Galimand, M., T. Lambert, G. Gerbaud, and P. Courvalin. 1993. Characterization of the aac(6′)-Ib gene encoding an aminoglycoside 6′-N-acetyl-transferase in Pseudomonas aeruginosa BM2656. Antimicrob. Agents Chemother. 37:1456-1462.
10. Gu, Z., R. Harrod, E. J. Rogers, and P. Lovett. 1994. Anti-peptidyl transferase leader peptides of attenuation-regulated chloramphenicol-resistance genes. Proc. Natl. Acad. Sci. USA 91:5612-5616.
11. Guerineau, F., L. Brooks, and P. Mullineaux. 1990. Expression of the sulfonamide resistance gene from plasmid R46. Plasmid 23:35-41.
12. Hall, R. M., D. E. Brookes, and H. W. Stokes. 1991. Site-specific insertion genes into integrons: role of the 59-base element and determination of the recombination cross-over point. Mol. Microbiol. 5:1941-1959.
13. Hall, R. M., H. J. Brown, D. E. Brookes, and H. W. Stokes. 1994. Integrons found in different locations have identical 5′ ends but variable 3′ ends. J. Bacteriol. 176:6286-6294.
14. Hall, R. M., and C. M. Collis. 1995. Mobile gene cassettes and integrons: capture and spread of genes by site-specific recombination. Mol. Microbiol. 15:593-600.
15. Hansson, K., O. Sköld, and L. Sundström. 1997. Non-palindromic attI sites of integrons are capable of site-specific recombination with one another and with secondary targets. Mol. Microbiol. 26:441-453.
16. Innis, M. A., D. H. Gelfand, J. J. Snisky, and T. J. White. 1990. PCR protocols. Academic Press. Inc., New York, N.Y.
17. Kim, E., and T. Aoki. 1996. Sequence analysis of the florfenicol resistance gene encoded in the transferable R-plasmid of a fish pathogen, Pasteurella piscicida. Microbiol. Immunol. 40:665-669.
18. Lévesque, R. C., and P. H. Roy. 1993. PCR analysis of integrons, p. 590-594. In D. H. Persing, T. F. Smith, F. C. Tenover, and T. J. White (ed.), Diagnostic molecular microbiology: principles and applications. American Society for Microbiology, Washington, D.C.
19. Littlejohn, T. G., I. T. Paulsen, M. T. Gillepsie, J. M. Tennent, M. Midgley, I. G. Jones, A. S. Purewal, and R. A. Skurray. 1992. Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus. FEMS Microbiol. Lett. 95:259-266.
20. Lovett, P. S. 1990. Translational attenuation as the regulator of inducible cat genes. J. Bacteriol. 172:1-6.
21. Mazel, D., B. Dychinco, V. Webb, and J. Davies. 1998. A distinctive class of integron in the Vibrio cholerae genome. Science 280:605-608.
22. Paulsen, I. T., T. G. Littlejohn, P. Radström, L. Sundström, O. Sköld, G. Swedberg, and R. A. Skurray. 1993. The 3′ conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants. Antimicrob. Agents Chemother. 37:761-768.
23. Pearson, W. R., and D. J. Lipman. 1988. Improved tools for biological sequence analysis. Proc. Natl. Acad. Sci. USA 85:2444-2448.
24. Ploy, M. C., H. Giamarellou, P. Bourlioux, P. Courvalin, and T. Lambert. 1994. Detection of aac(6′)-I genes in amikacin-resistant Acinetobacter spp. by PCR. Antimicrob. Agents Chemother. 38:2925-2928.
25. Ploy, M. C., C. Grélaud, C. Martin, and F. Denis. 1997. Emergence at the Limoges Teaching Hospital of Enterobacter aerogenes strains producing a derepressed cephalosporinase: molecular epidemiology using the RAPD technique. Pathol. Biol. 45:404-408.
26. Purewal, A. S. 1991, Nucleotide sequence of the ethidium efflux gene from Escherichia coli. FEMS Microbiol. Lett. 82:229-232.
27. Radström, P., O. Sköld, G. Swedberg, J. Flensburg, P. H. Roy, and L. Sundström. 1994. Transposon Tn5090 of plasmid R751, which carries an integron, is related to Tn7, Mu, and the retroelements. J. Bacteriol. 176: 3257-3268.
28. Recchia, G. D., and R. M. Hall. 1995. Gene cassettes: a new class of mobile element. Microbiology 141:3015-3027.
29. Recchia, G. U., and R. M. Hall. 1997. Origins of the mobile gene cassettes found in integrons. Trends Microbiol. 5:389-394.
30. Recchia, G. D., H. H. Stokes, and R. M. Hall. 1994. Characterisation of specific and secondary recombination sites recognised by the integron DNA integrase. Nucleic Acids Res. 22:2071-2078.
31. Roussel, A., C. Carlier, G. Gerbaud, and Y. A. Chabbert. 1979. Reversible translocation of antibiotic resistance determinants in Salmonella ordonez. Mol. Gen. Genet. 169:13-25.
32. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
33. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
34. Shaw, K. J., P. N. Rather, F. J. Sabatelli, P. Mann, H. Munayyer, R. Mierzwa, G. L. Petrikkos, R. S. Hare, G. H. Miller, P. Bennett, and P. Downey. 1992. Characterization of the chromosomal aac(6′)-Ic from Serratia marcescens. Antimicrob. Agents Chemother. 36:1447-1455.
35. Spratt, B. G., P. J. Hedge, S. Heesen, A. Edelman, and J. K. Broome-Smith. 1986. Kanamycin-resistant vectors that are analogous of plasmids pUC8, pUC9, pEMBL8 and pEMBL9. Gene 41:337-342.
36. Steers, E., E. L. Foltz, B. S. Graves, and J. Riden. 1959. An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. Antibiot. Chemother. (Basel) 9:307-311.
37. Stokes, H. W., and R. M. Hall. 1991. Sequence analysis of the inducible chloramphenicol resistance determinant in the Tn1696 integron suggests regulation by translational attenuation. Plasmid 26:10-19.
38. Stokes, H. W., D. B. O'Gorman, G. D. Rechia, M. Parsekhian, and R. M. Hall. 1997. Structure and function of 59-base element recombination sites associated with mobile gene cassettes. Mol. Microbiol. 26:731-745.
39. Sundström, L., P. Radstrom, G. Swedberg, and O. Sköld. 1988. Site-specific recombination promotes linkage between trimethoprim and sulfonamide resistance genes. Sequence characterization of dhfrV and sull and a recombination active locus of Tn21. Mol. Gen. Genet. 213:191-201.
40. Tolmasky, M. E., and J, H. Crosa. 1993. Genetic organization of antibiotic resistance genes (auc(6′)-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331. Plasmid 29:31-40.
41. Triglia, T., M. G. Peterson, and D. J. Kemp. 1988. A procedure for in vitro amplification of DNA segments that lie outside the boundaries of known sequences. Nucleic Acids Res. 16:8186.
42. Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119.