Radiosensitivity of dermal and tumor fibroblasts derived from the same patient

Journal of Cancer Research and Clinical Oncology

Volumn 124, Issue 8, 1998, Pages 415-420

  Honkanen, J ^a   Rantanen, V ^a   Kulmala, J ^a   Grenman R ^a,b   Klemi, P ^a   Pekkola, K ^b  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Fibroblast; Radiosensitivity; SF2

Indexed keywords

ADENOCARCINOMA; ARTICLE; CANCER GRADING; CELL FRACTIONATION; CORRELATION FUNCTION; ENDOMETRIUM CANCER; FIBROBLAST; GENETIC ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIVITY; SKIN CELL; SQUAMOUS CELL CARCINOMA; STATISTICAL ANALYSIS; TUMOR CELL CULTURE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FIBROBLASTS; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; RADIATION TOLERANCE; SKIN; TUMOR CELLS, CULTURED; UTERINE NEOPLASMS;

EID: 0031658126     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050193     Document Type: Article

References (36)

1. Begg AC, Rusell NS, Knaken H, Lebesque JV (1993) Lack of correlation of human fibroblast radiosensitivity in vitro with early skin reactions in patients undergoing radiotherapy. Int J Radiat Biol 64:393-405
2. Brock WA, Tucker SL, Geara FB, Turesson I, Wike J, Nyman J, Peters J (1995) Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer. Int J Radiat Oncol Biol Phys 32:1371-1379
3. Burnet NG, Nyman J, Turesson I, Wurm R, Yarnold JR, Peacock JH (1994) The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules. Radiat Oncol 33:228-238
4. 0) T-lymphocytes, T-lymphocyte lines, lymphoblastoid cell lines and fibroblasts from normal donors, from ataxia-telangiectasia patients and from ataxia-telangiectasia heterozygotes. Int J Radiat Biol 54:929-943
5. Dahlberg WK, Little JB, Fletcher JA, Suit HD, Okunieff P (1993) Radio-sensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients. Int J Radiat Biol 63:191-198
6. Fertil B, Malaise EP (1985) Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 101 published survival curves. Int J Radiat Oncol Biol Phys 11:1699-1707
7. Formenti SC, Chak L, Gill P, Buess EM, Hill CK (1995) Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi's sarcoma. Int J Radiat Biol 68:411-412
8. Geara FB, Peters LJ, Ang KK, Wike JL, Sivon SS, Guttenberger R, Callender DL, Malaise EP, Brock WA (1992a) Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high-and low-dose-rate irradiation. Cancer Res 52:6348-6352
9. Geara FB, Peters LJ, Ang KK, Wike JL. Brock WA (1992b) Radio-sensitivity measurement of keratinocytes and fibroblasts from radiotherapy patients. Int J Radiat Oncol Biol Phys 24:287-293
10. Geara FB, Peters LJ, Ang KK, Wike JL, Brock WA (1993) Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys 27:1173-1179
11. Gery B, Coppey J, Little JB (1996) Modulation of clonogenieity. growth, and radiosensitivity of three human epidermoid tumor cell lines by a fibroblastic environment. Int J Radiat Oncol Biol Phys 34:1061-1071
12. Green MHL, Arlett CF, Cole J, Harcourt SA, Priestley A, Waugh APW, Stephens G, Beare DM, Brown NAP, Shun-Shin GA (1991) Comparative human cellular radiosensitivity. III. γ-radiation survival of cultured skin fibroblasts and resting T-lymphocytes from the peripheral blood of the same individual. Int J Radiat Biol 59:749-765
13. Grénman R, Burk D, Virolainen E, Buick RN, Church J, Schwartz DR, Carey TE (1989) Clonogenic cell assay for anchorage-dependent squamous carcinoma cell lines using limiting dilution. Int J Cancer 44:131-136
14. Johansen J, Bentzen SM, Overgaard J, Overgaard M (1994) Evidence for a positive correlation between in vitro radiosensitivity of normal human skin fibroblasts and the occurrence of subcutaneous fibrosis after radiotherapy. Int J Radiat Biol 66:407-412
15. Johansen J, Bentzen SM, Overgaard J, Overgaard M (1996) Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis. telangiectasia, and skin erythema alter radiotherapy. Radiot Oncol 40:101-109
16. Kulmala J, Rantanen V, Pekkola-Heino K, Tuominen J, Grénman R (1995) Dosimetry of irradiation models: the 96-well plate assay for testing radio-sensitivity of cell lines. Acta Oncol 34:105-109
17. 0 and skin fibroblasts in log phase. Radiat Res 122:326-332
18. Little JB, Nove J, Strong LC, Nichols WW (1988) Survival of human diploid skin fibroblasts from normal individuals after X-irradiation. Int J Radial Biol 54:899-910
19. Loeffler JS, Harris JR, Dahlberg WK, Little JB (1990) In vitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy for breast cancer. Radiat Res 121:220-226
20. 2-phase chromosomal aberrations, and cell cycle delay. Cancer Res 48:4535-4538
21. Pekkola-Heino K (1992) Radiation response of squamous cell carcinoma. In vitro studies with cell lines in a 96-well plate clonogenic assay. Thesis, University of Turku, Finland
22. Pekkola-Heino K, Kulmala J, Klemi P, Lakkala T, Aitasalo K, Joensuu H, Grénman R (1991) Effects of radiation fractionation on four squamous cell carcinoma lines with dissimilar inherent radiation sensitivity. J Cancer Res din Oncol 117:597 602
23. Pekkola-Heino K, Servomaa K, Kiuru A, Grénman R (1996) Increased radio-sensitivity is associated with p53 mutations in cell lines derived from oral cavity carcinoma. Acta Otolaryngol 116:341-344
24. Pekkola-Heino K, Servomaa K, Kiuru A, Grénman R (1998) Sublethal damage repair capacity of carcinoma cell lines and their p53 suppressor gene mutations. Head Neck (in press)
25. Ramsay J, Birrell G (1995) Normal tissue radiosensitivity in breast cancer patients. Int J Radiat Oncol Biol Phys 31:339-344
26. Rantanen V, Grenman S, Kulmala J, Alanen K, Lakkala T, Grenman R (1994) Sublethal damage repair after fractionated irradiation in endometrial cancer cell lines tested with the 96-well plate clonogenic assay. J Cancer Res Clin Oncol 120:712-716
27. Rudat V, Dietz A, Conradt C, Weber K-L, Flentje M (1997) In vitro radiosensitivity of primary human fibroblasts. Lack of correlation with acute radiation toxicity in patients with head and neck cancer. Radiother Oncol 43:181-188
28. Russell NS, Arlett CF, Bartelink H, Begg AC (1995) Use of fluorescence in situ hybridization to determine the relationship between chromosome aberrations and cell survival in eight human fibroblast strains. Int J Radiat Biol 68:185-196
29. Servomaa K, Kiurii A, Grénman R, Pulkkinen JO, Rytömaa T (1996) p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines. Cell Proliferation 29:219-230
30. Stausbøl-Grøn B, Nielsen OS, Bentzen SM, Overgaard J (1995) Selective assessment of in vitro radiosensitivity of tumor cells and fibroblasts from single tumor biopsies using immunocytochemical identification of colonies in the soft agar clonogenic assay. Radiot Oncol 37:87-99
31. Sugimoto M, Toguchida J, Kotoura Y, Yamamuro T, Utsumi H (1992) Intrinsic radiosensitivity and PLD repair in osteosarcoma cell lines. Int J Radiat Biol 62:469-474
32. Taylor AMR, Harnden DG, Arlett CF, Harcourt SA, Lehmann AR, Stevens S, Bridges BA (1975) Ataxia teleangiectasia: a human mutation with abnormal radiation sensitivity. Nature 258:427-429
33. Thilly WG, DeLuca JG, Furth EE, Hoppe H, Kaden DA, Krolenski JJ, Liber HL, Skopek TR, Slapikoff SA, Tizard RJ, Penman BW (1980) Gene-locus mutation assays in diploid human lymphoblast lines. In: De Serpes FJ, Hollaenedr A (eds) Chemical mutagens. Plenum, New York, pp 331-364
34. Tucker SL, Turesson I, Thames HD (1992) Evidence for individual differences in the radiosensitivity of human skin. Eur J Cancer 28:1783-1791
35. Tucker SL, Geara FB, Peters LJ, Brock WA (1996) How much could radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity? Radiot Oncol 38:103-113
36. Wurm R, Burnet NG, Duggal N, Yarnold JR, Peacock, JH (1994) Cellular radiosensitivity and DNA damage in primary human fibroblasts. Int J Radiat Oncol Biol Phys 30:625-633