Replacement of linoleic acid with α-linolenic acid does not alter blood lipids in normolipidaemic men

British Journal of Nutrition

Volumn 80, Issue 2, 1998, Pages 163-167

  Pang, D ^a   Allman Farinelli, M A ^a   Wong, T ^a   Barnes, R ^a   Kingham, K M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Blood lipids; Linoleic acid; Linseed oil; linolenic acid

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LINOLEIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LIPID BLOOD LEVEL; MALE; NORMAL HUMAN;

EID: 0031657934     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1017/s0007114598001068     Document Type: Article

References (34)

1. Bang HO & Dyerberg J (1972) Plasma lipids and lipoproteins in Greenlandic west coast Eskimos. Acta Medico Scandinavica 192, 85-94.
2. Bang HO, Dyerberg J & Hjørne N (1976) The composition of food consumed by Greenland Eskimos. Acta Medico Scandinavica 200, 69-73.
3. Becker N, Illingworth DR, Alaupovic P, Connor WE & Sundberg EE (1983) Effects of saturated, monounsaturated, and ω-6 polyunsaturated fatty acids on plasma lipids, lipoproteins, and apoproteins in humans. American Journal of Clinical Nutrition 37, 355-360.
4. Bonanome A & Grundy SM (1988) Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. New England Journal of Medicine 318, 1244-1248.
5. Criqui MH, Heiss G, Cohn R, Cowan LD, Suchindran CM, Bangdiwala S, Kritchevsky S, Jacobs DR Jr, O'Grady HK & Davis CE (1993) Plasma triglyceride level and mortality from coronary heart disease. New England Journal of Medicine 328, 1220-1225.
6. de Logeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Taboul P & Delaye J (1994) Mediterrenean α-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 343, 1454-1459.
7. Dyerberg J, Bang HO & Hjørne N (1975) Fatty acid composition of the plasma lipids in Greenland Eskimos. American Journal of Clinical Nutrition 28, 958-966.
8. Folch J, Lees M & Sloane-Stanley G (1957) A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 226, 497-509.
9. Friedewald WT, Levy RI & Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of the preparative ultracentrifuge. Clinical Chemistry 18, 449-502.
10. Grundy SM & Vega GL (1988) Plasma cholesterol responsiveness to saturated fatty acids. American Journal of Clinical Nutrition 47, 822-824.
11. Harris WS (1997) n-3 Fatty acids and serum lipoproteins; human studies. American Journal of Clinical Nutrition 65, 1645S-1654S.
12. Harris WS, Connor WE, Alam N & Illingworth DR (1988) Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. Journal of Lipid Research 29, 1451-1460.
13. Hegsted DN, McGandy RB, Myers SM & Stare FJ (1965) Quantitative effects of dietary fat on blood cholesterol in man. American Journal of Clinical Nutrition 14, 776-787.
14. Kelley DS, Nelson GJ, Love JE, Branch LB, Taylor PC, Schmidt PC, Mackey BE & Iacono JM (1993) Dietary α-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans. Lipids 28, 533-537.
15. Kestin M, Clifton P, Belling GB & Nestel PJ (1990) n-3 Fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. American Journal of Clinical Nutrition 51, 1028-1034.
16. Kromhout D, Bosschieter EB, Drijver M & de Lezenne Coulander C (1988) Serum cholesterol and 25-year incidence of and mortality from myocardial infarction and cancer. The Zutphen Study. Archives of Internal Medicine 148, 1051-1055.
17. Lepage G & Roy CC (1986) Direct transesterification of all classes of lipids in a one-step reaction. Journal of Lipid Research 27, 114-120.
18. Lewis J, Holt R & English R (1992) Composition of Foods Australia: 6. Canberra: Australian Government Publishing Service.
19. 2 and prostacyclin production in healthy young men. American Journal of Clinical Nutrition 50, 1382-1388.
20. Mantzioris E, James MJ, Gibson RA & Cleland LG (1994) Dietary substitution with an α-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. American Journal of Clinical Nutrition 59, 1304-1309.
21. National Institute of Health Consensus Conference (1993) Triglyceride, high-density lipoprotein, and coronary heart disease. Journal of the American Medical Association 269, 505-510.
22. Pekkanen J, Linn S, Heiss G, Suchindran CM, Leon A, Rifkind BM & Tyroler HA (1990) Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease. New England Journal of Medicine 332, 1700-1707.
23. Rose G & Shipley M (1986) Plasma cholesterol concentration and death from coronary heart disease: 10 year results of the Whitehall study. British Medical Journal 293, 306-307.
24. Rustan AC, Nossen JØ, Christiansen EN & Drevon CA (1988) Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A: l,2-diacylglycerol acyltransferase. Journal of Lipid Research 29, 1417-1426.
25. 3 subfractions, and the risk of acute myocardial infarction. Circulation 84, 129-139.
26. Sanders TAB & Roshanai F (1983) The influence of different types of ω3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. Clinical Science 64, 91-99.
27. Sanders TAB, Vickers M & Haines AP (1981) Effect of blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. Clinical Science 61, 317-324.
28. Singer P, Wirth M & Berger I (1990) A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. Atherosclerosis 83, 167-175.
29. Truswell AS, Craske JD, English R, Nestel PJ, Sinclair A, Lester IH & Lilburne A (1992) The Role of Polyunsaturated Fats in the Australian Diet. Report of the National Health and Medical Research Council Working Party. Canberra: Australian Government Publishing Service.
30. Valsta LM, Jauhiainen M, Aro A, Salminen I & Mutanen M (1995) The effects on serum lipoprotein levels of two monounsaturated fat rich diets differing in their linoleic and α-linolenic acid contents. Nutrition and Metabolism in Cardiovascular Disease 5, 129-140.
31. von Schacky C, Fischer S & Weber PC (1985) Long-term effects of dietary marine ω-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. Journal of Clinical Investigation 76, 1626-1631.
32. Wardlaw GM, Snook JT, Lin MC, Puangco MA & Kwon JS ( 1991) Serum lipid and apolipoprotein concentrations in healthy men on diets enriched with either canola oil or safflower oil. American Journal of Clinical Nutrition 54, 104-110.
33. 2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clinical Chemistry 28, 1379-1388.
34. Zucker ML, Bilyeu DS, Helmkamp GM, Harris WS & Dujovne CA (1988) Effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects. Atherosclerosis 73, 13-22.